KEGG   PATHWAY: dse03440Help
Entry
dse03440                    Pathway                                

Name
Homologous recombination - Drosophila sechellia
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
dse03440

All organismsOrtholog table
Module
RPA complex [PATH:dse03440]
MRN complex [PATH:dse03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:dse03440]
Other DBs
BSID: 
GO: 
Organism
Drosophila sechellia [GN:dse]
Gene
GM15451 gene product from transcript GM15451-RA; K03111 single-strand DNA-binding protein [KO:K03111]
GM15911 gene product from transcript GM15911-RA; K10866 DNA repair protein RAD50 [EC:3.6.-.-] [KO:K10866] [EC:3.6.-.-]
GM19007 gene product from transcript GM19007-RA; K10865 double-strand break repair protein MRE11 [KO:K10865]
GM24846 gene product from transcript GM24846-RA; K10867 nijmegen breakage syndrome protein 1 [KO:K10867]
GM26360 gene product from transcript GM26360-RA; K07466 replication factor A1 [KO:K07466]
GM26361 gene product from transcript GM26361-RA; K07466 replication factor A1 [KO:K07466]
GM23291 gene product from transcript GM23291-RA; K10739 replication factor A2 [KO:K10739]
GM13057 gene product from transcript GM13057-RA; K10740 replication factor A3 [KO:K10740]
GM12184 gene product from transcript GM12184-RA; K04482 DNA repair protein RAD51 [KO:K04482]
GM16322 gene product from transcript GM16322-RA; K10881 26 proteasome complex subunit DSS1 [KO:K10881]
GM10376 gene product from transcript GM10376-RA; K10870 RAD51-like protein 2 [KO:K10870]
GM24163 gene product from transcript GM24163-RA; K10880 DNA-repair protein XRCC3 [KO:K10880]
GM18177 gene product from transcript GM18177-RA; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
GM24454 gene product from transcript GM24454-RA; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
GM24455 gene product from transcript GM24455-RA; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
GM14443 gene product from transcript GM14443-RA; K02328 DNA polymerase delta subunit 2 [KO:K02328]
GM14500 gene product from transcript GM14500-RA; K03504 DNA polymerase delta subunit 3 [KO:K03504]
GM26077 gene product from transcript GM26077-RA; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
GM17356 gene product from transcript GM17356-RA; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
GM12581 gene product from transcript GM12581-RA; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
GM19103 gene product from transcript GM19103-RA; K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] [KO:K08991] [EC:3.1.22.-]
GM21238 gene product from transcript GM21238-RA; K10882 crossover junction endonuclease EME1 [EC:3.1.22.-] [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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