KEGG   PATHWAY: dse03440Help
Entry
dse03440                    Pathway                                

Name
Homologous recombination - Drosophila sechellia
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
dse03440

All organismsOrtholog table
Module
RPA complex [PATH:dse03440]
MRN complex [PATH:dse03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:dse03440]
Other DBs
BSID: 
GO: 
Organism
Drosophila sechellia [GN:dse]
Gene
GM15451 gene product from transcript GM15451-RA [KO:K03111]
GM15911 gene product from transcript GM15911-RA [KO:K10866] [EC:3.6.-.-]
GM19007 gene product from transcript GM19007-RA [KO:K10865]
GM24846 gene product from transcript GM24846-RA [KO:K10867]
GM25794 gene product from transcript GM25794-RA [KO:K04728] [EC:2.7.11.1]
GM17633 gene product from transcript GM17633-RA [KO:K10728]
GM17634 gene product from transcript GM17634-RA [KO:K10728]
GM16322 gene product from transcript GM16322-RA [KO:K10881]
GM26360 gene product from transcript GM26360-RA [KO:K07466]
GM26361 gene product from transcript GM26361-RA [KO:K07466]
GM23291 gene product from transcript GM23291-RA [KO:K10739]
GM13057 gene product from transcript GM13057-RA [KO:K10740]
GM12184 gene product from transcript GM12184-RA [KO:K04482]
GM10376 gene product from transcript GM10376-RA [KO:K10870]
GM21107 gene product from transcript GM21107-RA [KO:K10871]
GM24163 gene product from transcript GM24163-RA [KO:K10880]
GM18177 gene product from transcript GM18177-RA [KO:K10875] [EC:3.6.4.-]
GM24455 gene product from transcript GM24455-RA [KO:K02327] [EC:2.7.7.7]
GM24454 gene product from transcript GM24454-RA [KO:K02327] [EC:2.7.7.7]
GM14443 gene product from transcript GM14443-RA [KO:K02328]
GM14500 gene product from transcript GM14500-RA [KO:K03504]
GM26077 gene product from transcript GM26077-RA [KO:K10901] [EC:3.6.4.12]
GM17356 gene product from transcript GM17356-RA [KO:K03165] [EC:5.99.1.2]
GM12581 gene product from transcript GM12581-RA [KO:K03165] [EC:5.99.1.2]
GM19103 gene product from transcript GM19103-RA [KO:K08991] [EC:3.1.22.-]
GM21238 gene product from transcript GM21238-RA [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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