KEGG   PATHWAY: dse04141Help
Entry
dse04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Drosophila sechellia
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum
dse04141

All organismsOrtholog table
Module
SCF-FBS complex [PATH:dse04141]
p97-Ufd1-Npl4 complex [PATH:dse04141]
Sec61 complex [PATH:dse04141]
Translocon-associated protein (TRAP) complex [PATH:dse04141]
HRD1/SEL1 ERAD complex [PATH:dse04141]
COPII complex [PATH:dse04141]
Other DBs
Organism
Drosophila sechellia [GN:dse]
Gene
GM17934 gene product from transcript GM17934-RA; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
GM21558 gene product from transcript GM21558-RA; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
GM19788 gene product from transcript GM19788-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
GM20379 gene product from transcript GM20379-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
GM22977 gene product from transcript GM22977-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
GM17862 gene product from transcript GM17862-RA; K12275 translocation protein SEC62 [KO:K12275]
GM14835 gene product from transcript GM14835-RA; K09540 translocation protein SEC63 [KO:K09540]
GM11699 gene product from transcript GM11699-RA; K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I) [KO:K12666]
GM19951 gene product from transcript GM19951-RA; K12667 oligosaccharyltransferase complex subunit delta (ribophorin II) [KO:K12667]
GM12988 gene product from transcript GM12988-RA; K12668 oligosaccharyltransferase complex subunit epsilon [KO:K12668]
GM13078 gene product from transcript GM13078-RA; K12669 oligosaccharyltransferase complex subunit gamma [KO:K12669]
GM13675 gene product from transcript GM13675-RA; K12670 oligosaccharyltransferase complex subunit beta [KO:K12670]
GM22642 gene product from transcript GM22642-RA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
GM17756 gene product from transcript GM17756-RA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
GM11245 gene product from transcript GM11245-RA; K01228 mannosyl-oligosaccharide glucosidase [EC:3.2.1.106] [KO:K01228] [EC:3.2.1.106]
GM17740 gene product from transcript GM17740-RA; K14001 nucleotide exchange factor SIL1 [KO:K14001]
GM18894 gene product from transcript GM18894-RA; K09486 hypoxia up-regulated 1 [KO:K09486]
GM13044 gene product from transcript GM13044-RA; K09490 heat shock 70kDa protein 5 [KO:K09490]
GM16745 gene product from transcript GM16745-RA; K09517 DnaJ homolog subfamily B member 11 [KO:K09517]
GM22763 gene product from transcript GM22763-RA; K09521 DnaJ homolog subfamily C member 1 [KO:K09521]
GM23820 gene product from transcript GM23820-RA; K09523 DnaJ homolog subfamily C member 3 [KO:K09523]
GM16365 gene product from transcript GM16365-RA; K09487 heat shock protein 90kDa beta [KO:K09487]
GM22613 gene product from transcript GM22613-RA; K05546 alpha 1,3-glucosidase [EC:3.2.1.84] [KO:K05546] [EC:3.2.1.84]
GM17123 gene product from transcript GM17123-RA; K08288 protein kinase C substrate 80K-H [KO:K08288]
GM13395 gene product from transcript GM13395-RA; K08054 calnexin [KO:K08054]
GM20403 gene product from transcript GM20403-RA; K08056 protein disulfide isomerase family A, member 3 [EC:5.3.4.1] [KO:K08056] [EC:5.3.4.1]
GM26236 gene product from transcript GM26236-RA; K08057 calreticulin [KO:K08057]
GM12266 gene product from transcript GM12266-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
GM11326 gene product from transcript GM11326-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
GM12204 gene product from transcript GM12204-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
GM23505 gene product from transcript GM23505-RA; K10082 lectin, mannose-binding 2 [KO:K10082]
GM25064 gene product from transcript GM25064-RA; K10080 lectin, mannose-binding 1 [KO:K10080]
GM17959 gene product from transcript GM17959-RA; K14003 prolactin regulatory element-binding protein [KO:K14003]
GM26415 gene product from transcript GM26415-RA; K07953 GTP-binding protein SAR1 [EC:3.6.5.-] [KO:K07953] [EC:3.6.5.-]
GM26501 gene product from transcript GM26501-RA; K14004 protein transport protein SEC13 [KO:K14004]
GM21072 gene product from transcript GM21072-RA; K14005 protein transport protein SEC31 [KO:K14005]
GM10828 gene product from transcript GM10828-RA; K14006 protein transport protein SEC23 [KO:K14006]
GM20571 gene product from transcript GM20571-RA; K14007 protein transport protein SEC24 [KO:K14007]
GM18251 gene product from transcript GM18251-RA; K14007 protein transport protein SEC24 [KO:K14007]
GM15000 gene product from transcript GM15000-RA; K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-] [KO:K11718] [EC:2.4.1.-]
GM18936 gene product from transcript GM18936-RA; K10085 ER degradation enhancer, mannosidase alpha-like 2 [KO:K10085]
GM10224 gene product from transcript GM10224-RA; K10086 ER degradation enhancer, mannosidase alpha-like 3 [KO:K10086]
GM24501 gene product from transcript GM24501-RA; K09580 protein disulfide-isomerase A1 [EC:5.3.4.1] [KO:K09580] [EC:5.3.4.1]
GM17901 gene product from transcript GM17901-RA; K09584 protein disulfide-isomerase A6 [EC:5.3.4.1] [KO:K09584] [EC:5.3.4.1]
GM21940 gene product from transcript GM21940-RA; K09586 endoplasmic reticulum protein 29 [KO:K09586]
GM13104 gene product from transcript GM13104-RA; K13984 thioredoxin domain-containing protein 5 [KO:K13984]
GM14630 gene product from transcript GM14630-RA; K10950 ERO1-like protein alpha [EC:1.8.4.-] [KO:K10950] [EC:1.8.4.-]
GM26418 gene product from transcript GM26418-RA; K14008 endoplasmic reticulum lectin 1 [KO:K14008]
GM11361 gene product from transcript GM11361-RA; K13249 translocon-associated protein subunit alpha [KO:K13249]
GM25590 gene product from transcript GM25590-RA; K13250 translocon-associated protein subunit beta [KO:K13250]
GM12147 gene product from transcript GM12147-RA; K13251 translocon-associated protein subunit gamma [KO:K13251]
GM20435 gene product from transcript GM20435-RA; K04571 translocon-associated protein subunit delta [KO:K04571]
GM14356 gene product from transcript GM14356-RA; K14009 B-cell receptor-associated protein 31 [KO:K14009]
GM19101 gene product from transcript GM19101-RA; K14010 translocating chain-associated membrane protein 1 [KO:K14010]
GM16838 gene product from transcript GM16838-RA; K11519 Derlin-1 [KO:K11519]
GM15426 gene product from transcript GM15426-RA; K13989 Derlin-2/3 [KO:K13989]
GM19889 gene product from transcript GM19889-RA; K14011 UBX domain-containing protein 6 [KO:K14011]
GM20792 gene product from transcript GM20792-RA; K14012 UBX domain-containing protein 1 [KO:K14012]
GM25133 gene product from transcript GM25133-RA; K14014 small VCP/p97-interacting protein [KO:K14014]
GM21173 gene product from transcript GM21173-RA; K13525 transitional endoplasmic reticulum ATPase [KO:K13525]
GM10234 gene product from transcript GM10234-RA; K14015 nuclear protein localization protein 4 homolog [KO:K14015]
GM24769 gene product from transcript GM24769-RA; K14016 ubiquitin fusion degradation protein 1 [KO:K14016]
GM24082 gene product from transcript GM24082-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
GM24208 gene product from transcript GM24208-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
GM23988 gene product from transcript GM23988-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
GM25439 gene product from transcript GM25439-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
Dsec_Hsp68; GM23516 gene product from transcript GM23516-RA [KO:K03283]
GM26058 gene product from transcript GM26058-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
GM24106 gene product from transcript GM24106-RA; K09502 DnaJ homolog subfamily A member 1 [KO:K09502]
GM24147 gene product from transcript GM24147-RA; K09518 DnaJ homolog subfamily B member 12 [KO:K09518]
GM22437 gene product from transcript GM22437-RA; K09525 DnaJ homolog subfamily C member 5 [KO:K09525]
Dsec_Hsp83; GM14548 gene product from transcript GM14548-RA [KO:K04079]
GM25449 gene product from transcript GM25449-RA; K09485 heat shock protein 110kDa [KO:K09485]
GM24486 gene product from transcript GM24486-RA; K09556 BCL2-associated athanogene 2 [KO:K09556]
GM24633 gene product from transcript GM24633-RA; K09562 hsp70-interacting protein [KO:K09562]
GM15521 gene product from transcript GM15521-RA; K09542 crystallin, alpha B [KO:K09542]
GM14693 gene product from transcript GM14693-RA; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
GM16622 gene product from transcript GM16622-RA; K14018 phospholipase A-2-activating protein [KO:K14018]
GM26792 gene product from transcript GM26792-RA; K10839 UV excision repair protein RAD23 [KO:K10839]
GM26556 gene product from transcript GM26556-RA; K10839 UV excision repair protein RAD23 [KO:K10839]
GM22982 gene product from transcript GM22982-RA; K04523 ubiquilin [KO:K04523]
GM16531 gene product from transcript GM16531-RA; K01456 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52] [KO:K01456] [EC:3.5.1.52]
GM25932 gene product from transcript GM25932-RA; K10597 ubiquitin conjugation factor E4 B [EC:6.3.2.19] [KO:K10597] [EC:6.3.2.19]
GM10634 gene product from transcript GM10634-RA; K08860 eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1] [KO:K08860] [EC:2.7.11.1]
GM12941 gene product from transcript GM12941-RA; K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] [KO:K16196] [EC:2.7.11.1]
GM13399 gene product from transcript GM13399-RA; K03237 translation initiation factor 2 subunit 1 [KO:K03237]
GM26735 gene product from transcript GM26735-RA; K09054 cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
GM23629 gene product from transcript GM23629-RA; K14020 wolfamin [KO:K14020]
GM22124 gene product from transcript GM22124-RA; K08653 membrane-bound transcription factor site-1 protease [EC:3.4.21.112] [KO:K08653] [EC:3.4.21.112]
GM20407 gene product from transcript GM20407-RA; K07765 S2P endopeptidase [EC:3.4.24.85] [KO:K07765] [EC:3.4.24.85]
GM15809 gene product from transcript GM15809-RA; K09027 X box-binding protein 1 [KO:K09027]
GM26893 gene product from transcript GM26893-RA; K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] [KO:K08852] [EC:3.1.26.- 2.7.11.1]
GM26871 gene product from transcript GM26871-RA; K04426 mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25] [KO:K04426] [EC:2.7.11.25]
GM11518 gene product from transcript GM11518-RA; K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] [KO:K04431] [EC:2.7.12.2]
GM11912 gene product from transcript GM11912-RA; K04440 c-Jun N-terminal kinase [EC:2.7.11.24] [KO:K04440] [EC:2.7.11.24]
GM14125 gene product from transcript GM14125-RA; K10661 E3 ubiquitin-protein ligase MARCH6 [EC:6.3.2.19] [KO:K10661] [EC:6.3.2.19]
GM15358 gene product from transcript GM15358-RA; K04554 ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19] [KO:K04554] [EC:6.3.2.19]
GM25907 gene product from transcript GM25907-RA; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
GM23423 gene product from transcript GM23423-RA; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
GM16451 gene product from transcript GM16451-RA; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
GM22525 gene product from transcript GM22525-RA; K10666 E3 ubiquitin-protein ligase RNF5 [EC:6.3.2.19] [KO:K10666] [EC:6.3.2.19]
GM23543 gene product from transcript GM23543-RA; K14026 SEL1 protein [KO:K14026]
GM18427 gene product from transcript GM18427-RA; K09561 STIP1 homology and U-box containing protein 1 [EC:6.3.2.19] [KO:K09561] [EC:6.3.2.19]
GM25828 gene product from transcript GM25828-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM11457 gene product from transcript GM11457-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM14046 gene product from transcript GM14046-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM18094 gene product from transcript GM18094-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM16815 gene product from transcript GM16815-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM11560 gene product from transcript GM11560-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
GM22162 gene product from transcript GM22162-RA; K04556 parkin [EC:6.3.2.19] [KO:K04556] [EC:6.3.2.19]
GM14339 gene product from transcript GM14339-RA; K03868 RING-box protein 1 [KO:K03868]
GM19082 gene product from transcript GM19082-RA; K03868 RING-box protein 1 [KO:K03868]
GM20989 gene product from transcript GM20989-RA; K03347 cullin 1 [KO:K03347]
GM20386 gene product from transcript GM20386-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
GM22995 gene product from transcript GM22995-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
GM19084 gene product from transcript GM19084-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
GM15542 gene product from transcript GM15542-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  
Calcium cation
G00009  
 
G00010  
 
G00011  
 
G00012  
 
G10694  
 
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
KO pathway
 
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