KEGG   PATHWAY: dsi03440Help
Entry
dsi03440                    Pathway                                

Name
Homologous recombination - Drosophila simulans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
dsi03440

All organismsOrtholog table
Module
RPA complex [PATH:dsi03440]
MRN complex [PATH:dsi03440]
Other DBs
BSID: 
GO: 
Organism
Drosophila simulans [GN:dsi]
Gene
GD20303 gene product from transcript GD20303-RA; K03111 single-strand DNA-binding protein [KO:K03111]
GD11670 gene product from transcript GD11670-RA; K10866 DNA repair protein RAD50 [EC:3.6.-.-] [KO:K10866] [EC:3.6.-.-]
GD23775 gene product from transcript GD23775-RA; K10865 double-strand break repair protein MRE11 [KO:K10865]
GD12898 gene product from transcript GD12898-RA; K10867 nijmegen breakage syndrome protein 1 [KO:K10867]
GD20882 gene product from transcript GD20882-RA; K07466 replication factor A1 [KO:K07466]
GD20884 gene product from transcript GD20884-RA; K07466 replication factor A1 [KO:K07466]
GD21666 gene product from transcript GD21666-RA; K10739 replication factor A2 [KO:K10739]
GD15982 gene product from transcript GD15982-RA; K10740 replication factor A3 [KO:K10740]
GD17366 gene product from transcript GD17366-RA; K04482 DNA repair protein RAD51 [KO:K04482]
GD21329 gene product from transcript GD21329-RA; K10870 RAD51-like protein 2 [KO:K10870]
GD18959 gene product from transcript GD18959-RA; K10880 DNA-repair protein XRCC3 [KO:K10880]
GD12001 gene product from transcript GD12001-RA; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
GD12524 gene product from transcript GD12524-RA; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
GD13645 gene product from transcript GD13645-RA; K02328 DNA polymerase delta subunit 2 [KO:K02328]
GD21967 gene product from transcript GD21967-RA; K03504 DNA polymerase delta subunit 3 [KO:K03504]
GD20640 gene product from transcript GD20640-RA; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
GD16199 gene product from transcript GD16199-RA; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
GD24215 gene product from transcript GD24215-RA; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
GD16537 gene product from transcript GD16537-RA; K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] [KO:K08991] [EC:3.1.22.-]
GD10756 gene product from transcript GD10756-RA; K10882 crossover junction endonuclease EME1 [EC:3.1.22.-] [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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