KEGG PATHWAY: dsi04141

PATHWAY: dsi04141

Entry

dsi04141 Pathway

Name

Protein processing in endoplasmic reticulum - Drosophila simulans

Description

The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

dsi04141

Protein processing in endoplasmic reticulum

Module

dsi_M00382	SCF-FBS complex [PATH:dsi04141]
dsi_M00400	p97-Ufd1-Npl4 complex [PATH:dsi04141]
dsi_M00401	Sec61 complex [PATH:dsi04141]
dsi_M00402	Translocon-associated protein (TRAP) complex [PATH:dsi04141]
dsi_M00403	HRD1/SEL1 ERAD complex [PATH:dsi04141]
dsi_M00404	COPII complex [PATH:dsi04141]

Other DBs

BSID:

167375

GO:

0030433 0034976

Organism

Drosophila simulans [GN:dsi]

Gene

Dsim_GD22572	GD22572 gene product from transcript GD22572-RA; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Dsim_GD11064	GD11064 gene product from transcript GD11064-RA; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
Dsim_GD25279	GD25279 gene product from transcript GD25279-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Dsim_GD15244	GD15244 gene product from transcript GD15244-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Dsim_GD23649	GD23649 gene product from transcript GD23649-RA; K12275 translocation protein SEC62 [KO:K12275]
Dsim_GD14009	GD14009 gene product from transcript GD14009-RA; K09540 translocation protein SEC63 [KO:K09540]
Dsim_GD22265	GD22265 gene product from transcript GD22265-RA; K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I) [KO:K12666]
Dsim_GD25442	GD25442 gene product from transcript GD25442-RA; K12667 oligosaccharyltransferase complex subunit delta (ribophorin II) [KO:K12667]
Dsim_GD22410	GD22410 gene product from transcript GD22410-RA; K12668 oligosaccharyltransferase complex subunit epsilon [KO:K12668]
Dsim_GD22422	GD22422 gene product from transcript GD22422-RA; K12669 oligosaccharyltransferase complex subunit gamma [KO:K12669]
Dsim_GD16081	GD16081 gene product from transcript GD16081-RA; K12670 oligosaccharyltransferase complex subunit beta [KO:K12670]
Dsim_GD18237	GD18237 gene product from transcript GD18237-RA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
Dsim_GD24643	GD24643 gene product from transcript GD24643-RA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
Dsim_GD15993	GD15993 gene product from transcript GD15993-RA; K01228 mannosyl-oligosaccharide glucosidase [EC:3.2.1.106] [KO:K01228] [EC:3.2.1.106]
Dsim_GD18223	GD18223 gene product from transcript GD18223-RA; K14001 nucleotide exchange factor SIL1 [KO:K14001]
Dsim_GD16375	GD16375 gene product from transcript GD16375-RA; K09486 hypoxia up-regulated 1 [KO:K09486]
Dsim_GD15970	GD15970 gene product from transcript GD15970-RA; K09490 heat shock 70kDa protein 5 [KO:K09490]
Dsim_GD23027	GD23027 gene product from transcript GD23027-RA; K09517 DnaJ homolog subfamily B member 11 [KO:K09517]
Dsim_GD15599	GD15599 gene product from transcript GD15599-RA; K09521 DnaJ homolog subfamily C member 1 [KO:K09521]
Dsim_GD18630	GD18630 gene product from transcript GD18630-RA; K09523 DnaJ homolog subfamily C member 3 [KO:K09523]
Dsim_GD21359	GD21359 gene product from transcript GD21359-RA; K09487 heat shock protein 90kDa beta [KO:K09487]
Dsim_GD10555	GD10555 gene product from transcript GD10555-RA; K05546 alpha 1,3-glucosidase [EC:3.2.1.84] [KO:K05546] [EC:3.2.1.84]
Dsim_GD21864	GD21864 gene product from transcript GD21864-RA; K08288 protein kinase C substrate 80K-H [KO:K08288]
Dsim_GD17820	GD17820 gene product from transcript GD17820-RA; K08054 calnexin [KO:K08054]
Dsim_GD25877	Dsim_ERp60; GD25877 gene product from transcript GD25877-RA [KO:K08056] [EC:5.3.4.1]
Dsim_GD20777	GD20777 gene product from transcript GD20777-RA; K08057 calreticulin [KO:K08057]
Dsim_GD17544	GD17544 gene product from transcript GD17544-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
Dsim_GD17996	GD17996 gene product from transcript GD17996-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
Dsim_GD24646	GD24646 gene product from transcript GD24646-RA; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
Dsim_GD18315	GD18315 gene product from transcript GD18315-RA; K10082 lectin, mannose-binding 2 [KO:K10082]
Dsim_GD14102	GD14102 gene product from transcript GD14102-RA; K10080 lectin, mannose-binding 1 [KO:K10080]
Dsim_GD22598	GD22598 gene product from transcript GD22598-RA; K14003 prolactin regulatory element-binding protein [KO:K14003]
Dsim_GD20936	GD20936 gene product from transcript GD20936-RA; K07953 GTP-binding protein SAR1 [EC:3.6.5.-] [KO:K07953] [EC:3.6.5.-]
Dsim_GD21013	GD21013 gene product from transcript GD21013-RA; K14004 protein transport protein SEC13 [KO:K14004]
Dsim_GD10608	GD10608 gene product from transcript GD10608-RA; K14005 protein transport protein SEC31 [KO:K14005]
Dsim_GD19806	GD19806 gene product from transcript GD19806-RA; K14006 protein transport protein SEC23 [KO:K14006]
Dsim_GD22860	GD22860 gene product from transcript GD22860-RA; K14007 protein transport protein SEC24 [KO:K14007]
Dsim_GD10041	GD10041 gene product from transcript GD10041-RA; K14007 protein transport protein SEC24 [KO:K14007]
Dsim_GD14778	GD14778 gene product from transcript GD14778-RA; K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-] [KO:K11718] [EC:2.4.1.-]
Dsim_GD16401	GD16401 gene product from transcript GD16401-RA; K10085 ER degradation enhancer, mannosidase alpha-like 2 [KO:K10085]
Dsim_GD23871	GD23871 gene product from transcript GD23871-RA; K10086 ER degradation enhancer, mannosidase alpha-like 3 [KO:K10086]
Dsim_GD12572	GD12572 gene product from transcript GD12572-RA; K09580 protein disulfide-isomerase A1 [EC:5.3.4.1] [KO:K09580] [EC:5.3.4.1]
Dsim_GD21912	GD21912 gene product from transcript GD21912-RA; K09584 protein disulfide-isomerase A6 [EC:5.3.4.1] [KO:K09584] [EC:5.3.4.1]
Dsim_GD11437	GD11437 gene product from transcript GD11437-RA; K09586 endoplasmic reticulum protein 29 [KO:K09586]
Dsim_GD17042	GD17042 gene product from transcript GD17042-RA; K13984 thioredoxin domain-containing protein 5 [KO:K13984]
Dsim_GD22141	GD22141 gene product from transcript GD22141-RA; K14008 endoplasmic reticulum lectin 1 [KO:K14008]
Dsim_GD14599	GD14599 gene product from transcript GD14599-RA; K13250 translocon-associated protein subunit beta [KO:K13250]
Dsim_GD22325	GD22325 gene product from transcript GD22325-RA; K13251 translocon-associated protein subunit gamma [KO:K13251]
Dsim_GD25906	GD25906 gene product from transcript GD25906-RA; K04571 translocon-associated protein subunit delta [KO:K04571]
Dsim_GD13575	GD13575 gene product from transcript GD13575-RA; K14009 B-cell receptor-associated protein 31 [KO:K14009]
Dsim_GD16534	GD16534 gene product from transcript GD16534-RA; K14010 translocating chain-associated membrane protein 1 [KO:K14010]
Dsim_GD23120	GD23120 gene product from transcript GD23120-RA; K11519 Derlin-1 [KO:K11519]
Dsim_GD20283	GD20283 gene product from transcript GD20283-RA; K13989 Derlin-2/3 [KO:K13989]
Dsim_GD25372	GD25372 gene product from transcript GD25372-RA; K14011 UBX domain-containing protein 6 [KO:K14011]
Dsim_GD10253	GD10253 gene product from transcript GD10253-RA; K14012 UBX domain-containing protein 1 [KO:K14012]
Dsim_GD14170	GD14170 gene product from transcript GD14170-RA; K14014 small VCP/p97-interacting protein [KO:K14014]
Dsim_GD10706	GD10706 gene product from transcript GD10706-RA; K13525 transitional endoplasmic reticulum ATPase [KO:K13525]
Dsim_GD18187	GD18187 gene product from transcript GD18187-RA; K14015 nuclear protein localization protein 4 homolog [KO:K14015]
Dsim_GD12819	GD12819 gene product from transcript GD12819-RA; K14016 ubiquitin fusion degradation protein 1 [KO:K14016]
Dsim_GD18791	Dsim_Hsp70Ab; Heat-shock-protein-70Ab [KO:K03283]
Dsim_GD18326	Dsim_Hsp68; GD18326 gene product from transcript GD18326-RA [KO:K03283]
Dsim_GD20560	Dsim_Hsp70Ba; GD20560 gene product from transcript GD20560-RA [KO:K03283]
Dsim_GD18998	Dsim_Hsc70-4; GD18998 gene product from transcript GD18998-RA [KO:K03283]
Dsim_GD18878	GD18878 gene product from transcript GD18878-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
Dsim_GD20621	Dsim_Hsp70Aa; Heat-shock-protein-70Aa [KO:K03283]
Dsim_GD14466	GD14466 gene product from transcript GD14466-RA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
Dsim_GD18906	GD18906 gene product from transcript GD18906-RA; K09502 DnaJ homolog subfamily A member 1 [KO:K09502]
Dsim_GD18942	GD18942 gene product from transcript GD18942-RA; K09518 DnaJ homolog subfamily B member 12 [KO:K09518]
Dsim_GD17653	GD17653 gene product from transcript GD17653-RA; K09525 DnaJ homolog subfamily C member 5 [KO:K09525]
Dsim_GD13739	Dsim_Hsp83; Heat shock protein 83 [KO:K04079]
Dsim_GD14475	GD14475 gene product from transcript GD14475-RA; K09485 heat shock protein 110kDa [KO:K09485]
Dsim_GD12558	GD12558 gene product from transcript GD12558-RA; K09556 BCL2-associated athanogene 2 [KO:K09556]
Dsim_GD12702	GD12702 gene product from transcript GD12702-RA; K09562 hsp70-interacting protein [KO:K09562]
Dsim_GD25025	GD25025 gene product from transcript GD25025-RA; K09542 crystallin, alpha B [KO:K09542]
Dsim_GD13876	GD13876 gene product from transcript GD13876-RA; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
Dsim_GD22922	GD22922 gene product from transcript GD22922-RA; K14018 phospholipase A-2-activating protein [KO:K14018]
Dsim_GD21063	GD21063 gene product from transcript GD21063-RA; K10839 UV excision repair protein RAD23 [KO:K10839]
Dsim_GD24402	Dsim_Rad23; GD24402 gene product from transcript GD24402-RA [KO:K10839]
Dsim_GD15764	GD15764 gene product from transcript GD15764-RA; K04523 ubiquilin [KO:K04523]
Dsim_GD10391	GD10391 gene product from transcript GD10391-RA; K01456 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52] [KO:K01456] [EC:3.5.1.52]
Dsim_GD22092	GD22092 gene product from transcript GD22092-RA; K10597 ubiquitin conjugation factor E4 B [EC:6.3.2.19] [KO:K10597] [EC:6.3.2.19]
Dsim_GD19618	GD19618 gene product from transcript GD19618-RA; K08860 eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1] [KO:K08860] [EC:2.7.11.1]
Dsim_GD21576	GD21576 gene product from transcript GD21576-RA; K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] [KO:K16196] [EC:2.7.11.1]
Dsim_GD15749	GD15749 gene product from transcript GD15749-RA; K03237 translation initiation factor 2 subunit 1 [KO:K03237]
Dsim_GD17476	GD17476 gene product from transcript GD17476-RA; K09054 cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
Dsim_GD18439	GD18439 gene product from transcript GD18439-RA; K14020 wolfamin [KO:K14020]
Dsim_GD12102	GD12102 gene product from transcript GD12102-RA; K08653 membrane-bound transcription factor site-1 protease [EC:3.4.21.112] [KO:K08653] [EC:3.4.21.112]
Dsim_GD25883	GD25883 gene product from transcript GD25883-RA; K07765 S2P endopeptidase [EC:3.4.24.85] [KO:K07765] [EC:3.4.24.85]
Dsim_GD11567	GD11567 gene product from transcript GD11567-RA; K09027 X box-binding protein 1 [KO:K09027]
Dsim_GD20099	GD20099 gene product from transcript GD20099-RA; K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] [KO:K08852] [EC:3.1.26.- 2.7.11.1]
Dsim_GD19320	GD19320 gene product from transcript GD19320-RA; K04426 mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25] [KO:K04426] [EC:2.7.11.25]
Dsim_GD15909	GD15909 gene product from transcript GD15909-RA; K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] [KO:K04431] [EC:2.7.12.2]
Dsim_GD22289	GD22289 gene product from transcript GD22289-RA; K04440 c-Jun N-terminal kinase [EC:2.7.11.24] [KO:K04440] [EC:2.7.11.24]
Dsim_GD13395	GD13395 gene product from transcript GD13395-RA; K10661 E3 ubiquitin-protein ligase MARCH6 [EC:6.3.2.19] [KO:K10661] [EC:6.3.2.19]
Dsim_GD20228	GD20228 gene product from transcript GD20228-RA; K04554 ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19] [KO:K04554] [EC:6.3.2.19]
Dsim_GD20475	GD20475 gene product from transcript GD20475-RA; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
Dsim_GD11958	GD11958 gene product from transcript GD11958-RA; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
Dsim_GD24840	GD24840 gene product from transcript GD24840-RA; K04555 ubiquitin-conjugating enzyme E2 G2 [EC:6.3.2.19] [KO:K04555] [EC:6.3.2.19]
Dsim_GD21603	GD21603 gene product from transcript GD21603-RA; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
Dsim_GD15775	GD15775 gene product from transcript GD15775-RA; K10666 E3 ubiquitin-protein ligase RNF5 [EC:6.3.2.19] [KO:K10666] [EC:6.3.2.19]
Dsim_GD18357	GD18357 gene product from transcript GD18357-RA; K14026 SEL1 protein [KO:K14026]
Dsim_GD23704	Dsim_CHIP; GD23704 gene product from transcript GD23704-RA [KO:K09561] [EC:6.3.2.19]
Dsim_GD22710	GD22710 gene product from transcript GD22710-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD22227	GD22227 gene product from transcript GD22227-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD20402	GD20402 gene product from transcript GD20402-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD23095	GD23095 gene product from transcript GD23095-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD13323	GD13323 gene product from transcript GD13323-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD17077	GD17077 gene product from transcript GD17077-RA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
Dsim_GD12138	GD12138 gene product from transcript GD12138-RA; K04556 parkin [EC:6.3.2.19] [KO:K04556] [EC:6.3.2.19]
Dsim_GD16520	GD16520 gene product from transcript GD16520-RA; K03868 RING-box protein 1 [KO:K03868]
Dsim_GD11014	GD11014 gene product from transcript GD11014-RA; K03868 RING-box protein 1 [KO:K03868]
Dsim_GD10516	GD10516 gene product from transcript GD10516-RA; K03347 cullin 1 [KO:K03347]
Dsim_GD25859	GD25859 gene product from transcript GD25859-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Dsim_GD16521	GD16521 gene product from transcript GD16521-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Dsim_GD17469	GD17469 gene product from transcript GD17469-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Dsim_GD25046	GD25046 gene product from transcript GD25046-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Dsim_GD25016	GD25016 gene product from transcript GD25016-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]

Compound

C00076	Calcium cation
G00009
G00010
G00011
G00012
G10694

Reference

PMID:19491040

Authors

Naidoo N

Title

ER and aging-Protein folding and the ER stress response.

Journal

Ageing Res Rev 8:150-9 (2009)

Reference

PMID:18023214

Authors

Malhotra JD, Kaufman RJ

Title

The endoplasmic reticulum and the unfolded protein response.

Journal

Semin Cell Dev Biol 18:716-31 (2007)

Reference

PMID:20347046

Authors

Maattanen P, Gehring K, Bergeron JJ, Thomas DY

Title

Protein quality control in the ER: the recognition of misfolded proteins.

Journal

Semin Cell Dev Biol 21:500-11 (2010)

Reference

PMID:20219571

Authors

Stolz A, Wolf DH

Title

Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.

Journal

Biochim Biophys Acta 1803:694-705 (2010)

Reference

PMID:20112977

Authors

Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY

Title

Organization of the Sec61 translocon, studied by high resolution native electrophoresis.

Journal

J Proteome Res 9:1763-71 (2010)

KO pathway

ko04141

All links

Pathway (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (117)   
   KEGG GENES (117)   
All databases (122)   

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