KEGG   PATHWAY: dto03440Help
dto03440                    Pathway                                

Homologous recombination - Desulfobacula toluolica
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Pathway map
dto03440  Homologous recombination

Ortholog table
dto_M00260  DNA polymerase III complex, bacteria [PATH:dto03440]
Other DBs
BSID: 696657
GO: 0000724
Desulfobacula toluolica [GN:dto]
TOL2_C14800  recJ; RecJ: single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
TOL2_C41130  ssb; Ssb: singel-stranded DNA-binding protein, helix-destabilizing [KO:K03111]
TOL2_C22240  recO; RecO: DNA repair protein [KO:K03584]
TOL2_C13400  recR; RecR: recombination protein R [KO:K06187]
TOL2_C29730  recA; RecA: recombinase A [KO:K03553]
TOL2_C38880  polA; PolA: DNA polymerase I [KO:K02335] [EC:]
TOL2_C13570  ruvA; RuvA: holliday junction ATP-dependent DNA helicase [KO:K03550] [EC:]
TOL2_C13580  ruvB; RuvB: holliday junction ATP-dependent DNA helicase, subunit B [KO:K03551] [EC:]
TOL2_C13560  ruvC; RuvC: crossover junction endodeoxyribonuclease [KO:K01159] [EC:]
TOL2_C41890  recB; RecB: exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:]
TOL2_C41900  recC; RecC: exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:]
TOL2_C41910  exodeoxyribonuclease V, gamma subunit, fragment [KO:K03583] [EC:]
TOL2_C41880  recD; RecD: exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:]
TOL2_C17090  recD; RecD: DNA helicase, RecD/TraA type [KO:K03581] [EC:]
TOL2_C40110  recD2; RecD2: helicase, RecD/TraA family [KO:K03581] [EC:]
TOL2_C21170  dnaE; DnaE: DNA-directed DNA polymerase III, alpha subunit [KO:K02337] [EC:]
TOL2_C00010  dnaN; DnaN: DNA polymerase III, beta chain [KO:K02338] [EC:]
TOL2_C13420  dnaX; DnaX: DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:]
TOL2_C21020  holA; HolA: putative DNA-directed DNA polymerase III, delta subunit [KO:K02340] [EC:]
TOL2_C13270  holB; HolB: putative DNA-directed DNA polymerase III, delta subunit [KO:K02341] [EC:]
TOL2_C31550  putative exonuclease modulated with PAS domain [KO:K02342] [EC:]
TOL2_C38640  priA; PriA: primosomal protein N? [KO:K04066] [EC:3.6.4.-]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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