KEGG   PATHWAY: dto03440Help
Entry
dto03440                    Pathway                                

Name
Homologous recombination - Desulfobacula toluolica
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
dto03440  Homologous recombination
dto03440

Ortholog table
Module
dto_M00260  DNA polymerase III complex, bacteria [PATH:dto03440]
Other DBs
BSID: 696657
GO: 0000724
Organism
Desulfobacula toluolica [GN:dto]
Gene
TOL2_C14800  recJ; RecJ: single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
TOL2_C41130  ssb; Ssb: singel-stranded DNA-binding protein, helix-destabilizing [KO:K03111]
TOL2_C22240  recO; RecO: DNA repair protein [KO:K03584]
TOL2_C13400  recR; RecR: recombination protein R [KO:K06187]
TOL2_C29730  recA; RecA: recombinase A [KO:K03553]
TOL2_C38880  polA; PolA: DNA polymerase I [KO:K02335] [EC:2.7.7.7]
TOL2_C13570  ruvA; RuvA: holliday junction ATP-dependent DNA helicase [KO:K03550] [EC:3.6.4.12]
TOL2_C13580  ruvB; RuvB: holliday junction ATP-dependent DNA helicase, subunit B [KO:K03551] [EC:3.6.4.12]
TOL2_C13560  ruvC; RuvC: crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
TOL2_C41890  recB; RecB: exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
TOL2_C41900  recC; RecC: exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
TOL2_C41910  exodeoxyribonuclease V, gamma subunit, fragment [KO:K03583] [EC:3.1.11.5]
TOL2_C41880  recD; RecD: exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
TOL2_C17090  recD; RecD: DNA helicase, RecD/TraA type [KO:K03581] [EC:3.1.11.5]
TOL2_C40110  recD2; RecD2: helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
TOL2_C21170  dnaE; DnaE: DNA-directed DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
TOL2_C00010  dnaN; DnaN: DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
TOL2_C13420  dnaX; DnaX: DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
TOL2_C21020  holA; HolA: putative DNA-directed DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
TOL2_C13270  holB; HolB: putative DNA-directed DNA polymerase III, delta subunit [KO:K02341] [EC:2.7.7.7]
TOL2_C31550  putative exonuclease modulated with PAS domain [KO:K02342] [EC:2.7.7.7]
TOL2_C38640  priA; PriA: primosomal protein N? [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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