KEGG   PATHWAY: dya04142Help
Entry
dya04142                    Pathway                                

Name
Lysosome - Drosophila yakuba
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Lysosome
dya04142

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Drosophila yakuba [GN:dya]
Gene
dyak_GLEANR_14040; GE13869 gene product from transcript GE13869-RA [KO:K02154]
dyak_GLEANR_2326; GE18538 gene product from transcript GE18538-RA [KO:K02154]
dyak_GLEANR_8827; GE25200 gene product from transcript GE25200-RA [KO:K02154]
dyak_GLEANR_8826; GE25199 gene product from transcript GE25199-RA [KO:K02154]
dyak_GLEANR_7588; GE23836 gene product from transcript GE23836-RA [KO:K02154]
dyak_GLEANR_17752; GE16319 gene product from transcript GE16319-RA [KO:K02146]
dyak_GLEANR_7717; GE23978 gene product from transcript GE23978-RA [KO:K02146]
dyak_GLEANR_13405; GE13171 gene product from transcript GE13171-RA [KO:K02144]
Dyak_CG8029; GE19265 gene product from transcript GE19265-RA [KO:K03662]
Dyak_Vha16; GE24687 gene product from transcript GE24687-RA [KO:K02155]
dyak_GLEANR_1360; GE13384 gene product from transcript GE13384-RA [KO:K02155]
dyak_GLEANR_14371; GE14233 gene product from transcript GE14233-RA [KO:K02155]
dyak_GLEANR_5543; GE21812 gene product from transcript GE21812-RA [KO:K02155]
dyak_GLEANR_5544; GE21813 gene product from transcript GE21813-RA [KO:K02155]
dyak_GLEANR_9961; GE26419 gene product from transcript GE26419-RA [KO:K03661]
dyak_GLEANR_9963; GE26421 gene product from transcript GE26421-RA [KO:K03661]
Dyak_CG10992; GE16138 gene product from transcript GE16138-RA [KO:K01363] [EC:3.4.22.1]
dyak_GLEANR_737; GE23596 gene product from transcript GE23596-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_13783; GE13586 gene product from transcript GE13586-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_2278; GE18490 gene product from transcript GE18490-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_10082; GE10129 gene product from transcript GE10129-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_2279; GE18491 gene product from transcript GE18491-RA [KO:K01379] [EC:3.4.23.5]
Dyak_CG13095; GE10927 gene product from transcript GE10927-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_10080; GE10127 gene product from transcript GE10127-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_10081; GE10128 gene product from transcript GE10128-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_1891; GE17593 gene product from transcript GE17593-RA [KO:K01379] [EC:3.4.23.5]
dyak_GLEANR_1893; GE17615 gene product from transcript GE17615-RA [KO:K01379] [EC:3.4.23.5]
Dyak_CG12163; GE25302 gene product from transcript GE25302-RA [KO:K01373] [EC:3.4.22.41]
dyak_GLEANR_12817; GE12574 gene product from transcript GE12574-RA [KO:K01365] [EC:3.4.22.15]
dyak_GLEANR_14221; GE14068 gene product from transcript GE14068-RA [KO:K01189] [EC:3.2.1.22]
dyak_GLEANR_2743; GE18961 gene product from transcript GE18961-RA [KO:K12309] [EC:3.2.1.23]
dyak_GLEANR_9721; GE26154 gene product from transcript GE26154-RA [KO:K12309] [EC:3.2.1.23]
dyak_GLEANR_10313; GE10384 gene product from transcript GE10384-RA [KO:K01201] [EC:3.2.1.45]
dyak_GLEANR_10315; GE10386 gene product from transcript GE10386-RA [KO:K01201] [EC:3.2.1.45]
dyak_GLEANR_1326; GE13010 gene product from transcript GE13010-RA [KO:K01217] [EC:3.2.1.76]
dyak_GLEANR_990; GE26351 gene product from transcript GE26351-RA [KO:K01204] [EC:3.2.1.49]
dyak_GLEANR_1091; GE10991 gene product from transcript GE10991-RA [KO:K01205] [EC:3.2.1.50]
dyak_GLEANR_14032; GE13860 gene product from transcript GE13860-RA [KO:K01195] [EC:3.2.1.31]
dyak_GLEANR_7097; GE23298 gene product from transcript GE23298-RA [KO:K01195] [EC:3.2.1.31]
dyak_GLEANR_13653; GE13443 gene product from transcript GE13443-RA [KO:K12373] [EC:3.2.1.52]
dyak_GLEANR_5195; GE21437 gene product from transcript GE21437-RA [KO:K12373] [EC:3.2.1.52]
dyak_GLEANR_17280; GE15800 gene product from transcript GE15800-RA [KO:K12373] [EC:3.2.1.52]
dyak_GLEANR_9028; GE25394 gene product from transcript GE25394-RA [KO:K01192] [EC:3.2.1.25]
dyak_GLEANR_1380; GE13604 gene product from transcript GE13604-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_1068; GE10784 gene product from transcript GE10784-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_1067; GE10773 gene product from transcript GE10773-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_1066; GE10763 gene product from transcript GE10763-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_1065; GE10752 gene product from transcript GE10752-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_2252; GE18464 gene product from transcript GE18464-RA [KO:K12311] [EC:3.2.1.24]
dyak_GLEANR_13583; GE13365 gene product from transcript GE13365-RA [KO:K01137] [EC:3.1.6.14]
dyak_GLEANR_5129; GE21364 gene product from transcript GE21364-RA [KO:K01136] [EC:3.1.6.13]
dyak_GLEANR_8793; GE25163 gene product from transcript GE25163-RA [KO:K01565] [EC:3.10.1.1]
dyak_GLEANR_8145; GE24449 gene product from transcript GE24449-RA [KO:K01052] [EC:3.1.1.13]
Dyak_CG18284; GE18475 gene product from transcript GE18475-RA [KO:K01052] [EC:3.1.1.13]
dyak_GLEANR_12832; GE12591 gene product from transcript GE12591-RA [KO:K06129] [EC:3.1.1.5]
dyak_GLEANR_9130; GE25505 gene product from transcript GE25505-RA [KO:K01158] [EC:3.1.22.1]
dyak_GLEANR_10190; GE10249 gene product from transcript GE10249-RA [KO:K14410] [EC:3.1.3.2]
dyak_GLEANR_10333; GE10406 gene product from transcript GE10406-RA [KO:K14410] [EC:3.1.3.2]
dyak_GLEANR_14518; GE14393 gene product from transcript GE14393-RA [KO:K12350] [EC:3.1.4.12]
dyak_GLEANR_13859; GE13669 gene product from transcript GE13669-RA [KO:K01444] [EC:3.5.1.26]
dyak_GLEANR_3063; GE19290 gene product from transcript GE19290-RA [KO:K01444] [EC:3.5.1.26]
dyak_GLEANR_12320; GE12034 gene product from transcript GE12034-RA [KO:K01444] [EC:3.5.1.26]
dyak_GLEANR_12318; GE12031 gene product from transcript GE12031-RA [KO:K01444] [EC:3.5.1.26]
dyak_GLEANR_7147; GE23352 gene product from transcript GE23352-RA [KO:K12382]
dyak_GLEANR_2310; GE18522 gene product from transcript GE18522-RA [KO:K01074] [EC:3.1.2.22]
dyak_GLEANR_18766; GE17436 gene product from transcript GE17436-RA [KO:K01074] [EC:3.1.2.22]
Dyak_CG3305; GE12921 gene product from transcript GE12921-RA [KO:K06528]
dyak_GLEANR_13128; GE12914 gene product from transcript GE12914-RA [KO:K06497]
dyak_GLEANR_2866; GE19090 gene product from transcript GE19090-RA [KO:K06497]
dyak_GLEANR_2867; GE19091 gene product from transcript GE19091-RA [KO:K06497]
Dyak_Tsp42Ed; GE24279 gene product from transcript GE24279-RA [KO:K06497]
dyak_GLEANR_2590; GE18806 gene product from transcript GE18806-RA [KO:K06497]
Dyak_Tsp42Ee; GE19093 gene product from transcript GE19093-RA [KO:K06497]
dyak_GLEANR_19188; GE17898 gene product from transcript GE17898-RA [KO:K12385]
dyak_GLEANR_988; GE26328 gene product from transcript GE26328-RA [KO:K12385]
dyak_GLEANR_1915; GE17856 gene product from transcript GE17856-RA [KO:K13443]
dyak_GLEANR_7154; GE23360 gene product from transcript GE23360-RA [KO:K13443]
dyak_GLEANR_7155; GE23361 gene product from transcript GE23361-RA [KO:K13443]
dyak_GLEANR_7727; GE23989 gene product from transcript GE23989-RA [KO:K12386]
Dyak_Mvl; GE25020 gene product from transcript GE25020-RA [KO:K12347]
dyak_GLEANR_655; GE22796 gene product from transcript GE22796-RA [KO:K12387]
dyak_GLEANR_4681; GE20871 gene product from transcript GE20871-RA [KO:K06546]
Dyak_CG5582; GE22116 gene product from transcript GE22116-RA [KO:K12389]
dyak_GLEANR_4262; GE20423 gene product from transcript GE20423-RA [KO:K12307]
dyak_GLEANR_17803; GE16376 gene product from transcript GE16376-RA [KO:K10532] [EC:2.3.1.78]
dyak_GLEANR_4841; GE21047 gene product from transcript GE21047-RA [KO:K13444]
dyak_GLEANR_10522; GE10613 gene product from transcript GE10613-RA [KO:K06564]
dyak_GLEANR_17478; GE16016 gene product from transcript GE16016-RA [KO:K04646]
dyak_GLEANR_17299; GE15820 gene product from transcript GE15820-RA [KO:K12391]
dyak_GLEANR_17344; GE15870 gene product from transcript GE15870-RA [KO:K12392]
dyak_GLEANR_8430; GE24766 gene product from transcript GE24766-RA [KO:K12393]
dyak_GLEANR_7219; GE23431 gene product from transcript GE23431-RA [KO:K12394]
Dyak_g; garnet [KO:K12396]
dyak_GLEANR_18235; GE16853 gene product from transcript GE16853-RA [KO:K12397]
dyak_GLEANR_18869; GE17549 gene product from transcript GE17549-RA [KO:K12398]
dyak_GLEANR_14480; GE14351 gene product from transcript GE14351-RA [KO:K12399]
dyak_GLEANR_19099; GE17800 gene product from transcript GE17800-RA [KO:K12404]
dyak_GLEANR_14163; GE14003 gene product from transcript GE14003-RA [KO:K19363]
dyak_GLEANR_14169; GE14009 gene product from transcript GE14009-RA [KO:K19363]
dyak_GLEANR_14170; GE14011 gene product from transcript GE14011-RA [KO:K19363]
dyak_GLEANR_14164; GE14004 gene product from transcript GE14004-RA [KO:K19363]
Dyak_CG13512; GE14005 gene product from transcript GE14005-RA [KO:K19363]
dyak_GLEANR_14167; GE14007 gene product from transcript GE14007-RA [KO:K19363]
dyak_GLEANR_14168; GE14008 gene product from transcript GE14008-RA [KO:K19363]
Compound
C00002  
ATP
C00008  
ADP
C00159  
D-Mannose
C00275  
D-Mannose 6-phosphate
Reference
  Authors
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
  Title
Molecular Biology of the Cell 4th ed.
  Journal
Garland Science (2002)
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
Reference
  Authors
Uchiyama Y.
  Title
[The analysis of a knockout mouse.] ( In Japanese)
  Journal
Cell Technology 25:1322-27 (2006)
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
KO pathway
 

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