KEGG   PATHWAY: dya04142Help
Entry
dya04142                    Pathway                                

Name
Lysosome - Drosophila yakuba
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Lysosome
dya04142

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Drosophila yakuba [GN:dya]
Gene
uncharacterized protein [KO:K02154]
uncharacterized protein [KO:K02154]
uncharacterized protein [KO:K02154]
uncharacterized protein, isoform A [KO:K02154]
uncharacterized protein, isoform B [KO:K02154]
uncharacterized protein [KO:K02146]
uncharacterized protein [KO:K02146]
uncharacterized protein, isoform A [KO:K02144]
uncharacterized protein [KO:K03662]
Dyak_Vha16; Vha16, isoform A [KO:K02155]
uncharacterized protein [KO:K02155]
uncharacterized protein [KO:K02155]
uncharacterized protein [KO:K02155]
uncharacterized protein [KO:K02155]
uncharacterized protein [KO:K03661]
uncharacterized protein [KO:K03661]
uncharacterized protein [KO:K01363] [EC:3.4.22.1]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein, isoform A [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein [KO:K01379] [EC:3.4.23.5]
uncharacterized protein, isoform A [KO:K01373] [EC:3.4.22.41]
uncharacterized protein [KO:K01365] [EC:3.4.22.15]
uncharacterized protein [KO:K01365] [EC:3.4.22.15]
uncharacterized protein [KO:K01365] [EC:3.4.22.15]
uncharacterized protein [KO:K01365] [EC:3.4.22.15]
uncharacterized protein, isoform A [KO:K01365] [EC:3.4.22.15]
uncharacterized protein, isoform A [KO:K01189] [EC:3.2.1.22]
uncharacterized protein [KO:K12309] [EC:3.2.1.23]
uncharacterized protein [KO:K12309] [EC:3.2.1.23]
uncharacterized protein [KO:K01201] [EC:3.2.1.45]
uncharacterized protein [KO:K01201] [EC:3.2.1.45]
uncharacterized protein, isoform A [KO:K01217] [EC:3.2.1.76]
uncharacterized protein [KO:K01204] [EC:3.2.1.49]
uncharacterized protein [KO:K01205] [EC:3.2.1.50]
uncharacterized protein, isoform A [KO:K01195] [EC:3.2.1.31]
uncharacterized protein [KO:K01195] [EC:3.2.1.31]
uncharacterized protein, isoform A [KO:K12373] [EC:3.2.1.52]
uncharacterized protein [KO:K12373] [EC:3.2.1.52]
uncharacterized protein, isoform A [KO:K01192] [EC:3.2.1.25]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K12311] [EC:3.2.1.24]
uncharacterized protein [KO:K01137] [EC:3.1.6.14]
uncharacterized protein [KO:K01136] [EC:3.1.6.13]
uncharacterized protein [KO:K01565] [EC:3.10.1.1]
uncharacterized protein, isoform A [KO:K01052] [EC:3.1.1.13]
uncharacterized protein [KO:K01052] [EC:3.1.1.13]
uncharacterized protein, isoform B [KO:K01052] [EC:3.1.1.13]
uncharacterized protein, isoform A [KO:K01052] [EC:3.1.1.13]
uncharacterized protein [KO:K06129] [EC:3.1.1.5]
uncharacterized protein [KO:K01158] [EC:3.1.22.1]
uncharacterized protein [KO:K01158] [EC:3.1.22.1]
uncharacterized protein [KO:K14410] [EC:3.1.3.2]
uncharacterized protein, isoform A [KO:K14410] [EC:3.1.3.2]
uncharacterized protein, isoform A [KO:K12350] [EC:3.1.4.12]
uncharacterized protein [KO:K01444] [EC:3.5.1.26]
uncharacterized protein [KO:K01444] [EC:3.5.1.26]
uncharacterized protein [KO:K01444] [EC:3.5.1.26]
uncharacterized protein [KO:K12382]
uncharacterized protein [KO:K01074] [EC:3.1.2.22]
uncharacterized protein [KO:K01074] [EC:3.1.2.22]
uncharacterized protein, isoform A [KO:K06528]
uncharacterized protein, isoform E [KO:K06497]
uncharacterized protein [KO:K06497]
uncharacterized protein [KO:K06497]
Dyak_Tsp42Ed; Tsp42Ed [KO:K06497]
uncharacterized protein, isoform A [KO:K06497]
Dyak_Tsp42Ee; Tsp42Ee [KO:K06497]
uncharacterized protein [KO:K12385]
uncharacterized protein [KO:K12385]
uncharacterized protein [KO:K13443]
uncharacterized protein [KO:K13443]
uncharacterized protein [KO:K13443]
uncharacterized protein [KO:K13443]
uncharacterized protein [KO:K13443]
uncharacterized protein, isoform A [KO:K13443]
uncharacterized protein [KO:K12386]
uncharacterized protein [KO:K12301]
Dyak_Mvl; Mvl [KO:K21398]
uncharacterized protein, isoform C [KO:K12387]
uncharacterized protein [KO:K06546]
uncharacterized protein, isoform A [KO:K12389]
uncharacterized protein [KO:K12307]
uncharacterized protein [KO:K10532] [EC:2.3.1.78]
uncharacterized protein [KO:K13444]
uncharacterized protein, isoform A [KO:K06564]
uncharacterized protein, isoform A [KO:K04646]
uncharacterized protein, isoform A [KO:K12391]
uncharacterized protein [KO:K12392]
uncharacterized protein [KO:K12393]
uncharacterized protein, isoform A [KO:K12394]
Dyak_g; garnet [KO:K12396]
uncharacterized protein [KO:K12397]
uncharacterized protein [KO:K12398]
uncharacterized protein, isoform A [KO:K12399]
uncharacterized protein [KO:K12404]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein [KO:K19363]
uncharacterized protein, isoform A [KO:K19363]
Compound
C00002  
ATP
C00008  
ADP
C00159  
D-Mannose
C00275  
D-Mannose 6-phosphate
Reference
  Authors
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
  Title
Molecular Biology of the Cell 4th ed.
  Journal
Garland Science (2002)
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
KO pathway
 

DBGET integrated database retrieval system