KEGG   PATHWAY: dya04142Help
Entry
dya04142                    Pathway                                

Name
Lysosome - Drosophila yakuba
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Lysosome
dya04142

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BSID: 
GO: 
Organism
Drosophila yakuba [GN:dya]
Gene
GE13869 gene product from transcript GE13869-RA; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
GE18538 gene product from transcript GE18538-RA; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
GE25200 gene product from transcript GE25200-RA; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
GE25199 gene product from transcript GE25199-RA; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
GE23836 gene product from transcript GE23836-RA; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
GE16319 gene product from transcript GE16319-RA; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
GE23978 gene product from transcript GE23978-RA; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
GE13171 gene product from transcript GE13171-RA; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
GE19265 gene product from transcript GE19265-RA; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
Dyak_Vha16; GE24687 gene product from transcript GE24687-RA [KO:K02155]
GE13384 gene product from transcript GE13384-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
GE14233 gene product from transcript GE14233-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
GE21812 gene product from transcript GE21812-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
GE21813 gene product from transcript GE21813-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
GE26419 gene product from transcript GE26419-RA; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
GE26421 gene product from transcript GE26421-RA; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
GE16138 gene product from transcript GE16138-RA; K01363 cathepsin B [EC:3.4.22.1] [KO:K01363] [EC:3.4.22.1]
GE23596 gene product from transcript GE23596-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE13586 gene product from transcript GE13586-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE18490 gene product from transcript GE18490-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE10129 gene product from transcript GE10129-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE18491 gene product from transcript GE18491-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE10927 gene product from transcript GE10927-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE10127 gene product from transcript GE10127-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE10128 gene product from transcript GE10128-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE17593 gene product from transcript GE17593-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE17615 gene product from transcript GE17615-RA; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
GE25302 gene product from transcript GE25302-RA; K01373 cathepsin F [EC:3.4.22.41] [KO:K01373] [EC:3.4.22.41]
GE12574 gene product from transcript GE12574-RA; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
GE14068 gene product from transcript GE14068-RA; K01189 alpha-galactosidase [EC:3.2.1.22] [KO:K01189] [EC:3.2.1.22]
GE18961 gene product from transcript GE18961-RA; K12309 beta-galactosidase [EC:3.2.1.23] [KO:K12309] [EC:3.2.1.23]
GE26154 gene product from transcript GE26154-RA; K12309 beta-galactosidase [EC:3.2.1.23] [KO:K12309] [EC:3.2.1.23]
GE10384 gene product from transcript GE10384-RA; K01201 glucosylceramidase [EC:3.2.1.45] [KO:K01201] [EC:3.2.1.45]
GE10386 gene product from transcript GE10386-RA; K01201 glucosylceramidase [EC:3.2.1.45] [KO:K01201] [EC:3.2.1.45]
GE13010 gene product from transcript GE13010-RA; K01217 L-iduronidase [EC:3.2.1.76] [KO:K01217] [EC:3.2.1.76]
GE26351 gene product from transcript GE26351-RA; K01204 alpha-N-acetylgalactosaminidase [EC:3.2.1.49] [KO:K01204] [EC:3.2.1.49]
GE10991 gene product from transcript GE10991-RA; K01205 alpha-N-acetylglucosaminidase [EC:3.2.1.50] [KO:K01205] [EC:3.2.1.50]
GE13860 gene product from transcript GE13860-RA; K01195 beta-glucuronidase [EC:3.2.1.31] [KO:K01195] [EC:3.2.1.31]
GE23298 gene product from transcript GE23298-RA; K01195 beta-glucuronidase [EC:3.2.1.31] [KO:K01195] [EC:3.2.1.31]
GE15800 gene product from transcript GE15800-RA; K12373 hexosaminidase [EC:3.2.1.52] [KO:K12373] [EC:3.2.1.52]
GE13443 gene product from transcript GE13443-RA; K12373 hexosaminidase [EC:3.2.1.52] [KO:K12373] [EC:3.2.1.52]
GE21437 gene product from transcript GE21437-RA; K12373 hexosaminidase [EC:3.2.1.52] [KO:K12373] [EC:3.2.1.52]
GE25394 gene product from transcript GE25394-RA; K01192 beta-mannosidase [EC:3.2.1.25] [KO:K01192] [EC:3.2.1.25]
GE13604 gene product from transcript GE13604-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE10784 gene product from transcript GE10784-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE10773 gene product from transcript GE10773-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE10763 gene product from transcript GE10763-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE10752 gene product from transcript GE10752-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE18464 gene product from transcript GE18464-RA; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
GE13365 gene product from transcript GE13365-RA; K01137 N-acetylglucosamine-6-sulfatase [EC:3.1.6.14] [KO:K01137] [EC:3.1.6.14]
GE21364 gene product from transcript GE21364-RA; K01136 iduronate 2-sulfatase [EC:3.1.6.13] [KO:K01136] [EC:3.1.6.13]
GE25163 gene product from transcript GE25163-RA; K01565 N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1] [KO:K01565] [EC:3.10.1.1]
GE24449 gene product from transcript GE24449-RA; K01052 lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13] [KO:K01052] [EC:3.1.1.13]
GE12591 gene product from transcript GE12591-RA; K06129 lysophospholipase III [EC:3.1.1.5] [KO:K06129] [EC:3.1.1.5]
GE25505 gene product from transcript GE25505-RA; K01158 deoxyribonuclease II [EC:3.1.22.1] [KO:K01158] [EC:3.1.22.1]
GE14393 gene product from transcript GE14393-RA; K12350 sphingomyelin phosphodiesterase [EC:3.1.4.12] [KO:K12350] [EC:3.1.4.12]
GE13669 gene product from transcript GE13669-RA; K01444 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] [KO:K01444] [EC:3.5.1.26]
GE19290 gene product from transcript GE19290-RA; K01444 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] [KO:K01444] [EC:3.5.1.26]
GE12034 gene product from transcript GE12034-RA; K01444 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] [KO:K01444] [EC:3.5.1.26]
GE12031 gene product from transcript GE12031-RA; K01444 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] [KO:K01444] [EC:3.5.1.26]
GE23352 gene product from transcript GE23352-RA; K12382 saposin [KO:K12382]
GE17436 gene product from transcript GE17436-RA; K01074 palmitoyl-protein thioesterase [EC:3.1.2.22] [KO:K01074] [EC:3.1.2.22]
GE18522 gene product from transcript GE18522-RA; K01074 palmitoyl-protein thioesterase [EC:3.1.2.22] [KO:K01074] [EC:3.1.2.22]
GE12921 gene product from transcript GE12921-RA; K06528 lysosomal-associated membrane protein 1/2 [KO:K06528]
GE12914 gene product from transcript GE12914-RA; K06497 CD63 antigen [KO:K06497]
GE19090 gene product from transcript GE19090-RA; K06497 CD63 antigen [KO:K06497]
GE19091 gene product from transcript GE19091-RA; K06497 CD63 antigen [KO:K06497]
Dyak_Tsp42Ed; GE24279 gene product from transcript GE24279-RA [KO:K06497]
GE18806 gene product from transcript GE18806-RA; K06497 CD63 antigen [KO:K06497]
Dyak_Tsp42Ee; GE19093 gene product from transcript GE19093-RA [KO:K06497]
GE17898 gene product from transcript GE17898-RA; K12385 Niemann-Pick C1 protein [KO:K12385]
GE26328 gene product from transcript GE26328-RA; K12385 Niemann-Pick C1 protein [KO:K12385]
GE17856 gene product from transcript GE17856-RA; K13443 Niemann-Pick C2 protein [KO:K13443]
GE23361 gene product from transcript GE23361-RA; K13443 Niemann-Pick C2 protein [KO:K13443]
GE23360 gene product from transcript GE23360-RA; K13443 Niemann-Pick C2 protein [KO:K13443]
GE23989 gene product from transcript GE23989-RA; K12386 cystinosin [KO:K12386]
Dyak_Mvl; GE25020 gene product from transcript GE25020-RA [KO:K12347]
GE22796 gene product from transcript GE22796-RA; K12387 lysosomal-associated transmembrane protein [KO:K12387]
GE20871 gene product from transcript GE20871-RA; K06546 CD164 antigen [KO:K06546]
GE22116 gene product from transcript GE22116-RA; K12389 battenin [KO:K12389]
GE20423 gene product from transcript GE20423-RA; K12307 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 [KO:K12307]
GE16376 gene product from transcript GE16376-RA; K10532 heparan-alpha-glucosaminide N-acetyltransferase [EC:2.3.1.78] [KO:K10532] [EC:2.3.1.78]
GE21047 gene product from transcript GE21047-RA; K13444 sulfatase modifying factor 1 [KO:K13444]
GE10613 gene product from transcript GE10613-RA; K06564 insulin-like growth factor 2 receptor [KO:K06564]
GE16016 gene product from transcript GE16016-RA; K04646 clathrin heavy chain [KO:K04646]
GE15820 gene product from transcript GE15820-RA; K12391 AP-1 complex subunit gamma-1 [KO:K12391]
GE15870 gene product from transcript GE15870-RA; K12392 AP-1 complex subunit beta-1 [KO:K12392]
GE24766 gene product from transcript GE24766-RA; K12393 AP-1 complex subunit mu [KO:K12393]
GE23431 gene product from transcript GE23431-RA; K12394 AP-1 complex subunit sigma 1/2 [KO:K12394]
Dyak_g; garnet [KO:K12396]
GE16853 gene product from transcript GE16853-RA; K12397 AP-3 complex subunit beta [KO:K12397]
GE17549 gene product from transcript GE17549-RA; K12398 AP-3 complex subunit mu [KO:K12398]
GE14351 gene product from transcript GE14351-RA; K12399 AP-3 complex subunit sigma [KO:K12399]
GE17800 gene product from transcript GE17800-RA; K12404 ADP-ribosylation factor-binding protein GGA [KO:K12404]
Compound
C00002  
ATP
C00008  
ADP
C00159  
D-Mannose
C00275  
D-Mannose 6-phosphate
Reference
  Authors
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
  Title
Molecular Biology of the Cell 4th ed.
  Journal
Garland Science (2002)
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
Reference
  Authors
Uchiyama Y.
  Title
[The analysis of a knockout mouse.] ( In Japanese)
  Journal
Cell Technology 25:1322-27 (2006)
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
KO pathway
 

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