KEGG   PATHWAY: eba02010
Entry
eba02010                    Pathway                                
Name
ABC transporters - Aromatoleum aromaticum
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
eba02010  ABC transporters
eba02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Aromatoleum aromaticum [GN:eba]
Gene
ebA6204  cysP; Periplasmic thiosulfate-binding protein [KO:K02048]
ebA6206  cysT; Membrane component of thiosulfate ABC-transporter [KO:K02046]
ebA6207  cysW; Membrane component of thiosulfate ABC transporter [KO:K02047]
ebA6208  cysA; ATP-binding protein of thiosulfate ABC transporter [KO:K02045] [EC:7.3.2.3]
ebA3597  modB1; molybdate or tungstate transport [KO:K05772]
ebA5015  putative permease component of ABC transporter [KO:K05773]
ebA5014  similar to phosphate import ATP-binding protein pstB 1 [KO:K06857] [EC:7.3.2.6]
ebA2721  modA; Molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
ebA2720  modB; Molybdenum transport system permease [KO:K02018]
ebA2719  modC; Molybdenum import ATP-binding protein [KO:K02017] [EC:7.3.2.5]
ebA4918  putative iron binding protein component of ABC iron transporter [KO:K02012]
ebA4893  putative iron utilization protein [KO:K02011]
ebA4892  probable transport system ATP-binding protein [KO:K02010] [EC:7.2.2.7]
ebA2111  putative iron transport system ATP-binding protein [KO:K02010] [EC:7.2.2.7]
ebA1308  putative toluene tolerance protein [KO:K07323]
ebA5051  putative toluene tolerance protein [KO:K07323]
ebA2206  putative toluene tolerance protein [KO:K07323]
ebA6521  periplasmic component of probable ABC-type transport system involved in resistance to organic solvents [KO:K02067]
ebA1311  Mce related protein [KO:K02067]
ebA6524  Possible ABC transport permease [KO:K02066]
ebA1312  predicted ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
ebA1307  predicted NTP binding protein (contains STAS domain) [KO:K07122]
ebA6523  ATPase component, ABC-type transport system [KO:K02065]
ebA1313  putative ATP-binding ABC transporter protein [KO:K02065]
ebA4826  pstS; Phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
ebA4828  pstC; Phosphate ABC transporter, permease protein [KO:K02037]
ebA4829  pstA; Phosphate ABC transporter, permease protein [KO:K02038]
ebA4830  pstB; Phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
ebA4561  gltI; putative ABC transporter, glutamate receptor [KO:K10001]
ebA4562  gltK; putative ABC transporter protein,probable glutamate/aspartate transmembrane subunit [KO:K10002]
ebA4564  gltJ; putative ABC transporter protein,probable glutamate/aspartate transmembrane subunit [KO:K10003]
ebA4567  gltL; ABC transporter protein, ATP-binding component [KO:K10004] [EC:7.4.2.1]
ebA2755  ABC-transporter [KO:K01999]
ebA3556  putative amino-acid-binding periplasmic (PBP) ABC transporter protein [KO:K01999]
ebA3173  putative amino acid ABC transporter [KO:K01999]
ebA3175  putative amino acid ABC transporter [KO:K01999]
ebA3428  livK; predicted LivK, ABC-type branched-chain amino acid transport systems,periplasmic component [KO:K01999]
ebA5303  putative ABC transporter subunit [KO:K01999]
ebA5316  putative ABC transporter,periplasmic binding protein [KO:K01999]
ebA2070  Branched-chain amino acid ABC transporter [KO:K01999]
ebA127  Branched-chain amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
ebA2700  probablel eucine-Binding Protein (LBP) precursor [KO:K01999]
ebA2710  livM; predicted branched-chain amino acid ABC-type transport system, permease components [KO:K01997]
ebA3558  putative branched-chain amino acid transport system permease protein [KO:K01997]
ebA3172  putative amino-acid transmembrane ABC transporter protein [KO:K01997]
ebA3426  probable transmembrane ABC transporter protein [KO:K01997]
ebA5304  putative ABC-transporter [KO:K01997]
ebA2706  ABC transporter permease protein [KO:K01998]
ebA3559  putative branched-chain amino acid transport system protein [KO:K01995 K01998]
ebA3170  putative ABC transport protein [KO:K01998]
ebA3425  Possible ABC transporter, permease protein precursor [KO:K01998]
ebA5306  putative ABC-transporter [KO:K01998]
ebA3169  livG; Leucine/isoleucine/valine transport system ATP-binding protein [KO:K01995]
ebA3430  ATP-binding ABC transporter protein [KO:K01995]
ebA5307  putativ ABC-transporter [KO:K01995]
ebA3560  amino-acid composite ATP-binding transmembrane ABC transporter protein [KO:K01996]
ebA3167  livF; Leucine/isoleucine/valine transport system ATP-binding protein [KO:K01996]
ebA3429  ABC transporter subunit [KO:K01996]
ebA5309  putative ABC-transporter [KO:K01996]
ebA1592  putative ABC transporter [KO:K09690]
ebA1593  putative ABC-2 transporter hydrophilic component [KO:K09691] [EC:7.5.2.14]
ebA3579  nodJ; Nodulation protein J [KO:K09694]
ebA3580  nodI; Nod factor export ATP-binding protein I [KO:K09695]
ebA5819  conserved hypothetical protein [KO:K09808]
ebA5820  probable ATP-binding component, ABC transporter [KO:K09810] [EC:7.6.2.-]
ebD8  ccmD; Cytochrome c biogenesis protein [KO:K02196]
ebA3518  ccmC; Heme exporter, permease [KO:K02195]
ebA3516  ccmB; Heme exporter protein B [KO:K02194]
ebA3514  ccmA; Heme exporter protein A [KO:K02193] [EC:7.6.2.5]
ebA7173  conserved hypothetical protein [KO:K07091]
ebA7171  conserved hypothetical protein [KO:K11720]
ebA3394  putative ATP-binding ABC transporter protein [KO:K06861] [EC:7.5.2.5]
ebA6266  nosY; probable transmembrane protein [KO:K19341]
ebA6267  nosF; putative ATP-binding protein [KO:K19340]
ebA1387  ftsX; cell division protein FtsX [KO:K09811]
ebA1390  ftsE; cell division ATP-binding protein ftsE,ABC transporter ATP-binding protein [KO:K09812]
ebA3992  msbA; predicted ABC-type multidrug transport system protein [KO:K11085] [EC:7.5.2.6]
ebA1666  probable fusion of ABC transporter-type transmembrane and ATP binding protein [KO:K11004]
ebA2601  putative composite ATP-binding transmembrane ABC transporter protein [KO:K24821]
ebA1807  ABC transporter, ATP-binding/permease [KO:K12541]
ebA1848  Transmembrane ATP-binding ABC transporter protein [KO:K05685] [EC:7.6.2.-]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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Genome (1)   
   KEGG GENOME (1)   
Gene (81)   
   KEGG GENES (81)   
All databases (82)   

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