KEGG PATHWAY: ebi00030

PATHWAY: ebi00030

Entry

ebi00030 Pathway

Name

Pentose phosphate pathway - Erwinia billingiae

Description

The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].

Class

Metabolism; Carbohydrate metabolism

Pathway map

ebi00030

Pentose phosphate pathway

Module

ebi_M00004	Pentose phosphate pathway (Pentose phosphate cycle) [PATH:ebi00030]
ebi_M00005	PRPP biosynthesis, ribose 5P => PRPP [PATH:ebi00030]
ebi_M00006	Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:ebi00030]
ebi_M00007	Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:ebi00030]
ebi_M00008	Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:ebi00030]
ebi_M00308	Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde-3P + pyruvate [PATH:ebi00030]
ebi_M00309	Non-phosphorylative Entner-Doudoroff pathway, gluconate => glyceraldehyde + pyruvate [PATH:ebi00030]
ebi_M00580	Pentose phosphate pathway, archaea, fructose 6P => ribose 5P [PATH:ebi00030]

Other DBs

BSID:

154967

GO:

0006098

Organism

Erwinia billingiae [GN:ebi]

Gene

EbC_02990	pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
EbC_24960	zwf; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49]
EbC_22410	pgl; 6-phosphogluconolactonase [KO:K07404] [EC:3.1.1.31]
EbC_13330	pgl; 6-phosphogluconolactonase [KO:K07404] [EC:3.1.1.31]
EbC_29190	gnd; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44]
EbC_41860	rpe; Ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
EbC_33150	tktA; transketolase [KO:K00615] [EC:2.2.1.1]
EbC_18450	transketolase; K00615 transketolase [EC:2.2.1.1] [KO:K00615] [EC:2.2.1.1]
EbC_18440	transketolase; K00615 transketolase [EC:2.2.1.1] [KO:K00615] [EC:2.2.1.1]
EbC_36590	tktA; transketolase [KO:K00615] [EC:2.2.1.1]
EbC_06640	talB; transaldolase B [KO:K00616] [EC:2.2.1.2]
EbC_33140	talA; transaldolase A [KO:K00616] [EC:2.2.1.2]
EbC_36510	rpiA; ribose-5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]
EbC_33130	rpiB; ribose 5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
EbC_06080	deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
EbC_06220	deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
EbC_00190	rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
EbC_03290	carbohydrate/purine kinase; K00852 ribokinase [EC:2.7.1.15] [KO:K00852] [EC:2.7.1.15]
EbC_06230	sugar kinase; K00852 ribokinase [EC:2.7.1.15] [KO:K00852] [EC:2.7.1.15]
EbC_21650	rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
EbC_06100	deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
EbC_12800	pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
EbC_27490	phnN; ribose 1,5-bisphosphokinase [KO:K05774] [EC:2.7.4.23]
EbC_18240	prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
EbC_41500	phosphoribosylpyrophosphate synthetase; K00948 ribose-phosphate pyrophosphokinase [EC:2.7.6.1] [KO:K00948] [EC:2.7.6.1]
EbC_02850	6-phosphogluconate dehydratase; K01690 phosphogluconate dehydratase [EC:4.2.1.12] [KO:K01690] [EC:4.2.1.12]
EbC_24950	keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; K01625 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.16] [KO:K01625] [EC:4.1.3.16 4.1.2.14]
EbC_12100	gcd; quinoprotein glucose dehydrogenase [KO:K00117] [EC:1.1.5.2]
EbC_22470	quinoprotein glucose dehydrogenase; K00117 quinoprotein glucose dehydrogenase [EC:1.1.5.2] [KO:K00117] [EC:1.1.5.2]
EbC_03750	gluconate 2-dehydrogenase; K06151 gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] [KO:K06151] [EC:1.1.99.3]
EbC_28860	gluconate 2-dehydrogenase; K06151 gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] [KO:K06151] [EC:1.1.99.3]
EbC_11990	gluconate 2-dehydrogenase; K06151 gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] [KO:K06151] [EC:1.1.99.3]
EbC_37930	gluconate 2-dehydrogenase; K06151 gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] [KO:K06151] [EC:1.1.99.3]
EbC_44380	gluconate 2-dehydrogenase; K06151 gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] [KO:K06151] [EC:1.1.99.3]
EbC_03740	gluconate 2-dehydrogenase; K06152 gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3] [KO:K06152] [EC:1.1.99.3]
EbC_28850	recC; gluconate 2-dehydrogenase [KO:K06152] [EC:1.1.99.3]
EbC_11980	hypothetical protein; K06152 gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3] [KO:K06152] [EC:1.1.99.3]
EbC_37940	gluconate 2-dehydrogenase; K06152 gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3] [KO:K06152] [EC:1.1.99.3]
EbC_44370	gluconate 2-dehydrogenase; K06152 gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3] [KO:K06152] [EC:1.1.99.3]
EbC_45500	tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.215]
EbC_02860	carbohydrate kinase; K00851 gluconokinase [EC:2.7.1.12] [KO:K00851] [EC:2.7.1.12]
EbC_39210	idnK; D-gluconate kinase [KO:K00851] [EC:2.7.1.12]
EbC_42270	gntK; thermoresistant gluconokinase [KO:K00851] [EC:2.7.1.12]
EbC_43850	kdgK; Ketodeoxygluconokinase [KO:K00874] [EC:2.7.1.45]
EbC_45480	sugar kinase; K00874 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] [KO:K00874] [EC:2.7.1.45]
EbC_29670	fructose-biphosphate aldolase class I; K11645 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] [KO:K11645] [EC:4.1.2.13]
EbC_36560	fba; Fructose-bisphosphate aldolase class II [KO:K01624] [EC:4.1.2.13]
EbC_04800	fbp; Fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
EbC_01490	glpX; glycerol metabolic protein [KO:K02446] [EC:3.1.3.11]
EbC_01310	pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
EbC_37860	pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]

Compound

C00022	Pyruvate
C00031	D-Glucose
C00117	D-Ribose 5-phosphate
C00118	D-Glyceraldehyde 3-phosphate
C00119	5-Phospho-alpha-D-ribose 1-diphosphate
C00121	D-Ribose
C00198	D-Glucono-1,5-lactone
C00199	D-Ribulose 5-phosphate
C00204	2-Dehydro-3-deoxy-D-gluconate
C00221	beta-D-Glucose
C00231	D-Xylulose 5-phosphate
C00257	D-Gluconic acid
C00258	D-Glycerate
C00279	D-Erythrose 4-phosphate
C00345	6-Phospho-D-gluconate
C00577	D-Glyceraldehyde
C00620	alpha-D-Ribose 1-phosphate
C00631	2-Phospho-D-glycerate
C00668	alpha-D-Glucose 6-phosphate
C00672	2-Deoxy-D-ribose 1-phosphate
C00673	2-Deoxy-D-ribose 5-phosphate
C01151	D-Ribose 1,5-bisphosphate
C01172	beta-D-Glucose 6-phosphate
C01218	6-Phospho-2-dehydro-D-gluconate
C01236	D-Glucono-1,5-lactone 6-phosphate
C01801	Deoxyribose
C03752	2-Amino-2-deoxy-D-gluconate
C04442	2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345	beta-D-Fructose 6-phosphate
C05378	beta-D-Fructose 1,6-bisphosphate
C05382	Sedoheptulose 7-phosphate
C06019	D-arabino-Hex-3-ulose 6-phosphate
C06473	2-Keto-D-gluconic acid

Reference

(map 3)

Authors

Nishizuka Y (ed).

Title

[Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1980)

Reference

(map 4)

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

Authors

Michal G.

Title

Biochemical Pathways

Journal

Wiley (1999)

Reference

PMID:12700258

Authors

Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.

Title

Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.

Journal

J Bacteriol 185:2793-801 (2003)

Reference

PMID:16788179

Authors

Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y

Title

The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.

Journal

J Bacteriol 188:4698-704 (2006)

Reference

PMID:16428816

Authors

Kato N, Yurimoto H, Thauer RK

Title

The physiological role of the ribulose monophosphate pathway in bacteria and archaea.

Journal

Biosci Biotechnol Biochem 70:10-21 (2006)

KO pathway

ko00030

All links

Pathway (6)   
   KEGG MODULE (5)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (58)   

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