KEGG   PATHWAY: ebt03440Help
Entry
ebt03440                    Pathway                                

Name
Homologous recombination - Shimwellia blattae
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ebt03440  Homologous recombination
ebt03440

Ortholog table
Module
ebt_M00260  DNA polymerase III complex, bacteria [PATH:ebt03440]
Other DBs
BSID: 652889
GO: 0000724
Organism
Shimwellia blattae [GN:ebt]
Gene
EBL_c06930  Single-stranded-DNA-specific exonuclease recJ [KO:K07462] [EC:3.1.-.-]
EBL_c36530  ssb; single-strand binding protein [KO:K03111]
EBL_c22090  single strand DNA-binding protein [KO:K03111]
EBL_c00030  recF; DNA replication and repair protein RecF [KO:K03629]
EBL_c09980  recO; DNA repair protein RecO [KO:K03584]
EBL_c28520  recR; recombination and repair protein RecR [KO:K06187]
EBL_c08920  recA; DNA strand exchange and recombination protein with protease and nuclease activity [KO:K03553]
EBL_c39420  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EBL_c23220  ruvA; holliday junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
EBL_c23210  ruvB; holliday junction ATP-dependent DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
EBL_c23230  ruvC; holliday junction nuclease [KO:K01159] [EC:3.1.22.4]
EBL_c39270  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
EBL_c08100  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
EBL_c08080  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
EBL_c08110  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
EBL_c31810  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
EBL_c00020  dnaN; DNA polymerase III [KO:K02338] [EC:2.7.7.7]
EBL_c28540  dnaX; DNA polymerase III subunit tau [KO:K02343] [EC:2.7.7.7]
EBL_c27240  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
EBL_c24010  holB; DNA polymerase III [KO:K02341] [EC:2.7.7.7]
EBL_c31480  dnaQ; DNA polymerase III [KO:K02342] [EC:2.7.7.7]
EBL_c23050  holE; DNA polymerase III theta subunit [KO:K02345] [EC:2.7.7.7]
EBL_c34910  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
EBL_c33780  holD; DNA polymerase III [KO:K02344] [EC:2.7.7.7]
EBL_c38580  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
EBL_c35600  primosomal replication protein N [KO:K02686]
EBL_c28570  priC; primosomal replication protein N'' [KO:K04067]
EBL_c33900  dnaT; primosomal protein 1 [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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