KEGG   PATHWAY: ec00053Help
Entry
ec00053                     Pathway                                

Name
Ascorbate and aldarate metabolism
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
ec00053  Ascorbate and aldarate metabolism
ec00053

Ortholog table
Module
M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:ec00053]
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:ec00053]
M00283  PTS system, ascorbate-specific II component [PATH:ec00053]
M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:ec00053]
Other DBs
GO: 0019852 0019572
Enzyme
1.1.1.122   
1.1.1.129   
1.1.1.130   
1.1.1.19   
1.1.1.20   
1.1.1.203   
1.1.1.22   
1.1.1.316   
1.1.1.365   
1.1.1.376   
1.1.1.46   
1.1.3.8   
1.10.3.3   
1.11.1.11   
1.13.99.1   
1.2.1.26   
1.2.1.3   
1.3.2.3   
1.3.3.12   
1.6.5.4   
1.8.5.1   
2.4.1.17   
2.7.1.194   
2.7.1.43   
2.7.1.53   
2.7.7.44   
2.7.7.64   
2.7.7.69   
3.1.1.15   
3.1.1.17   
3.1.1.19   
3.1.1.25   
3.1.3.93   
4.1.1.85   
4.1.2.18   
4.1.2.20   
4.2.1.25   
4.2.1.40   
4.2.1.41   
4.2.1.42   
4.2.1.43   
5.1.3.18   
5.1.3.22   
5.1.3.4   
5.4.1.4   
5.5.1.27   
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00618  3-Dehydro-L-gulonate
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
KO pathway
ko00053   

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