KEGG   PATHWAY: ec00600Help
Entry
ec00600                     Pathway                                

Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Sphingolipid metabolism
ec00600

All organismsOrtholog table
Module
M00066  
Lactosylceramide biosynthesis [PATH:ec00600]
M00067  
Cerebroside and sulfatide biosynthesis [PATH:ec00600]
M00094  
Ceramide biosynthesis [PATH:ec00600]
M00099  
Sphingosine biosynthesis [PATH:ec00600]
M00100  
Sphingosine degradation [PATH:ec00600]
Other DBs
Enzyme
 
1.14.-.-  
 
 
 
 
2.4.1.-  
 
 
 
 
 
 
 
2.7.8.-  
 
 
 
 
 
3.1.3.-  
 
 
 
 
 
 
 
 
 
 
 
3.5.1.-  
 
 
 
Compound
C00065  
L-Serine
C00154  
Palmitoyl-CoA
C00195  
N-Acylsphingosine
C00319  
Sphingosine
C00346  
Ethanolamine phosphate
C00550  
Sphingomyelin
C00836  
Sphinganine
C01120  
Sphinganine 1-phosphate
C01190  
beta-D-Glucosyl-(1<->1)-ceramide
C01290  
beta-D-Galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C01747  
Psychosine
C02686  
Galactosylceramide
C02934  
3-Dehydrosphinganine
C02960  
Ceramide 1-phosphate
C03640  
Sphingosyl-phosphocholine
C05681  
Ceramide 2-aminoethylphosphonate
C06062  
Ceramide phosphoethanolamine
C06124  
Sphingosine 1-phosphate
C06125  
Sulfatide
C06126  
Digalactosylceramide
C06127  
Digalactosylceramidesulfate
C06128  
GM4
C12126  
Dihydroceramide
C12144  
Phytosphingosine
C12145  
Phytoceramide
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
KO pathway
 

DBGET integrated database retrieval system