KEGG   PATHWAY: ec00600Help
Entry
ec00600                     Pathway                                

Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ec00600  Sphingolipid metabolism
ec00600

Ortholog table
Module
M00066  Lactosylceramide biosynthesis [PATH:ec00600]
M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ec00600]
M00094  Ceramide biosynthesis [PATH:ec00600]
M00099  Sphingosine biosynthesis [PATH:ec00600]
M00100  Sphingosine degradation [PATH:ec00600]
Other DBs
GO: 0006665 0030148
Enzyme
1.1.1.102   
1.14.18.5   
1.14.19.17   
2.3.1.24   
2.3.1.50   
2.4.1.23   
2.4.1.274   
2.4.1.47   
2.4.1.80   
2.7.1.138   
2.7.1.91   
2.7.8.10   
2.7.8.27   
2.7.8.3   
2.8.2.11   
3.1.3.4   
3.1.4.12   
3.1.4.41   
3.1.6.1   
3.1.6.8   
3.2.1.18   
3.2.1.22   
3.2.1.23   
3.2.1.45   
3.2.1.46   
3.5.1.23   
4.1.2.27   
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  beta-D-Glucosyl-(1<->1)-ceramide
C01290  beta-D-Galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03640  Sphingosyl-phosphocholine
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
KO pathway
ko00600   

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