KEGG   PATHWAY: ec00980Help
Entry
ec00980                     Pathway                                

Name
Metabolism of xenobiotics by cytochrome P450
Class
Metabolism; Xenobiotics biodegradation and metabolism
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Metabolism of xenobiotics by cytochrome P450
ec00980

All organismsOrtholog table
Enzyme
 
 
 
1.14.13.-  
 
 
 
 
 
 
 
 
Compound
C00745  
Nicotine
C00829  
Naphthalene
C02617  
1,4-Naphthoquinone
C03012  
Naphthalene-1,2-diol
C06205  
1,2-Dihydronaphthalene-1,2-diol
C06755  
Chloroacetic acid
C06790  
Trichloroethene
C06800  
Aflatoxin B1
C06899  
Chloral hydrate
C07490  
Trichloroethanol
C07535  
Benzo[a]pyrene
C11036  
Bromobenzene
C11088  
1,2-Dibromoethane
C11148  
TCE epoxide
C11149  
Dichloroacetate
C11150  
Trichloroacetate
C11278  
Aflatoxin B1exo-8,9-epoxide-GSH
C11713  
2-Naphthol
C11714  
1-Naphthol
C14039  
1,1-Dichloroethylene
C14040  
1-Nitronaphthalene
C14453  
4-Bromophenol
C14556  
9-Hydroxybenzo[a]pyrene
C14783  
1,2-Naphthoquinone
C14784  
1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  
1,4-Dihydroxynaphthalene
C14786  
(1R,2S)-Naphthalene 1,2-oxide
C14787  
(1S,2R)-Naphthalene 1,2-oxide
C14788  
1-Nitrosonaphthalene
C14789  
N-Hydroxy-1-aminonaphthalene
C14790  
1-Naphthylamine
C14791  
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  
(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  
(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  
(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  
(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  
1-Nitronaphthalene-5,6-oxide
C14801  
1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  
1-Nitronaphthalene-7,8-oxide
C14803  
1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  
1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  
1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  
1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  
Bromobenzene-3,4-oxide
C14840  
Bromobenzene-2,3-oxide
C14841  
2-Bromophenol
C14842  
Bromobenzene-2,3-dihydrodiol
C14843  
4-Bromocatechol
C14844  
Bromobenzene-3,4-dihydrodiol
C14845  
4-Bromophenol-2,3-epoxide
C14846  
4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  
3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  
2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  
Benzo[a]pyrene-9,10-oxide
C14850  
Benzo[a]pyrene-7,8-oxide
C14851  
Benzo[a]pyrene-4,5-oxide
C14852  
Benzo[a]pyrene-7,8-diol
C14853  
Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  
9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  
4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  
7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  
1,1-Dichloroethylene epoxide
C14858  
2,2-Dichloroacetaldehyde
C14859  
Chloroacetyl chloride
C14860  
2,2-Dichloro-1,1-ethanediol
C14861  
S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  
2-S-Glutathionyl acetate
C14863  
2-(S-Glutathionyl)acetyl glutathione
C14864  
S-(2-Chloroacetyl)glutathione
C14865  
2-(S-Glutathionyl)acetyl chloride
C14866  
Chloral
C14867  
Dichloroacetyl chloride
C14868  
S-(1,2-Dichlorovinyl)glutathione
C14869  
Trichloroethanol glucuronide
C14870  
2-Bromoacetaldehyde
C14871  
S-(Formylmethyl)glutathione
C14872  
Thiodiacetic acid
C14873  
Thiodiacetic acid sulfoxide
C14874  
Glutathione episulfonium ion
C14875  
S-(2-Hydroxyethyl)glutathione
C14876  
S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  
S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  
Aflatoxin M1
C19488  
7,12-Dimethylbenz[a]anthracene
C19489  
1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  
trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  
(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  
7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  
7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  
4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  
4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  
4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  
4-Oxo-1-(3-pyridyl)-1-butanone
C19568  
N-Nitrosomethanamine
C19569  
3-Succinoylpyridine
C19574  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  
1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  
5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  
gamma-Hydroxy-3-pyridinebutanoate
C19580  
alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  
alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  
1-(3-Pyridinyl)-1,4-butanediol
C19585  
Aflatoxin Q1
C19586  
Aflatoxin B1-exo-8,9-epoxide
C19588  
Aflatoxin B1 diol
C19589  
Aflatoxin B1 dialdehyde
C19590  
6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  
1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  
alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  
Aflatoxin-M1-8,9-epoxide
C19595  
Aflatoxin B1-endo-8,9-epoxide
C19602  
4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  
7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  
NNAL-N-glucuronide
C19607  
trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
Reference
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
Reference
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
Reference
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
Reference
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)

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