KEGG   PATHWAY: ecb00590Help
Entry
ecb00590                    Pathway                                

Name
Arachidonic acid metabolism - Equus caballus (horse)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Arachidonic acid metabolism
ecb00590

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BSID: 
GO: 
Organism
Equus caballus (horse) [GN:ecb]
Gene
PLA2G3; phospholipase A2, group III [KO:K01047] [EC:3.1.1.4]
group IIC secretory phospholipase A2-like; K01047 secretory phospholipase A2 [EC:3.1.1.4] [KO:K01047] [EC:3.1.1.4]
PLA2G2F; phospholipase A2, group IIF [KO:K01047] [EC:3.1.1.4]
PLA2G2D; phospholipase A2, group IID [KO:K01047] [EC:3.1.1.4]
PLA2G2E; phospholipase A2, group IIE [KO:K01047] [EC:3.1.1.4]
PLA2G5; phospholipase A2, group V [KO:K01047] [EC:3.1.1.4]
PLA2G12B; phospholipase A2, group XIIB [KO:K01047] [EC:3.1.1.4]
PLA2G1B; phospholipase A2, group IB (pancreas) [KO:K01047] [EC:3.1.1.4]
PLA2G12A; phospholipase A2, group XIIA [KO:K01047] [EC:3.1.1.4]
SPLA2; secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
PLA2G10; phospholipase A2, group X [KO:K01047] [EC:3.1.1.4]
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
PLA2G6; phospholipase A2, group VI (cytosolic, calcium-independent) [KO:K16343] [EC:3.1.1.4]
PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
uncharacterized LOC100049811; K16817 HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4] [KO:K16817] [EC:3.1.1.4 3.1.1.32]
PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [KO:K00509] [EC:1.14.99.1]
791253  
PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [KO:K11987] [EC:1.14.99.1]
PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
PTGES3; prostaglandin E synthase 3 (cytosolic) [KO:K15730] [EC:5.3.99.3]
carbonyl reductase [NADPH] 1-like; K00079 carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197] [KO:K00079] [EC:1.1.1.197 1.1.1.189 1.1.1.184]
carbonyl reductase [NADPH] 1-like; K00079 carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197] [KO:K00079] [EC:1.1.1.197 1.1.1.189 1.1.1.184]
carbonyl reductase [NADPH] 2-like; K00081 carbonyl reductase 2 [EC:1.1.1.184] [KO:K00081] [EC:1.1.1.184]
CBR3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
FAM213B; family with sequence similarity 213, member B [KO:K15717] [EC:1.11.1.20]
TBXAS1; thromboxane A synthase 1 (platelet) [KO:K01832] [EC:5.3.99.5]
PTGDS; prostaglandin D2 synthase 21kDa (brain) [KO:K01830] [EC:5.3.99.2]
HPGDS; hematopoietic prostaglandin D synthase [KO:K01830] [EC:5.3.99.2]
aldo-keto reductase family 1 member C23-like protein-like; K04119 aldo-keto reductase family 1 member C3 [EC:1.1.1.64 1.1.1.188 1.1.1.213] [KO:K04119] [EC:1.1.1.213 1.1.1.188 1.1.1.64]
PTGIS; prostaglandin I2 (prostacyclin) synthase [KO:K01831] [EC:5.3.99.4]
ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
LTA4H; leukotriene A4 hydrolase [KO:K01254] [EC:3.3.2.6]
cytochrome P450 4F6-like; K17726 leukotriene-B4 20-monooxygenase / phylloquinone omega-hydroxylase [EC:1.14.13.30 1.14.13.194] [KO:K17726] [EC:1.14.13.194 1.14.13.30]
leukotriene-B(4) omega-hydroxylase 2-like; K17726 leukotriene-B4 20-monooxygenase / phylloquinone omega-hydroxylase [EC:1.14.13.30 1.14.13.194] [KO:K17726] [EC:1.14.13.194 1.14.13.30]
LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
GGT1; gamma-glutamyltransferase 1 [KO:K18592] [EC:3.4.19.14 3.4.19.13 2.3.2.2]
GGT5; gamma-glutamyltransferase 5 [KO:K18592] [EC:3.4.19.14 3.4.19.13 2.3.2.2]
GPX3; glutathione peroxidase 3 (plasma) [KO:K00432] [EC:1.11.1.9]
GPX5; glutathione peroxidase 5 (epididymal androgen-related protein) [KO:K00432] [EC:1.11.1.9]
GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
GPX2; glutathione peroxidase 2 (gastrointestinal) [KO:K00432] [EC:1.11.1.9]
GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
GPX6; glutathione peroxidase 6 (olfactory) [KO:K00432] [EC:1.11.1.9]
GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1 [KO:K07415] [EC:1.14.13.-]
cytochrome P450 2J2-like; K07418 cytochrome P450, family 2, subfamily J [EC:1.14.14.1] [KO:K07418] [EC:1.14.14.1]
cytochrome P450 2U1-like; K07422 cytochrome P450, family 2, subfamily U, polypeptide 1 [KO:K07422]
cytochrome P450 4A11-like; K17687 alkane 1-monooxygenase [EC:1.14.15.3] [KO:K17687] [EC:1.14.15.3]
ALOX12; arachidonate 12-lipoxygenase [KO:K00458] [EC:1.13.11.31]
arachidonate 12-lipoxygenase; K00458 arachidonate 12-lipoxygenase [EC:1.13.11.31] [KO:K00458] [EC:1.13.11.31]
ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.- 1.13.11.33]
cytochrome P450 2B4-like; K07412 cytochrome P450, family 2, subfamily B [EC:1.14.14.1] [KO:K07412] [EC:1.14.14.1]
CYP2C113; cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
cytochrome P450 2C26-like; K07413 cytochrome P450, family 2, subfamily C [EC:1.14.14.1] [KO:K07413] [EC:1.14.14.1]
CYP2C92; cytochrome P450 2C92 [KO:K07413] [EC:1.14.14.1]
cytochrome P450 2C21-like; K07413 cytochrome P450, family 2, subfamily C [EC:1.14.14.1] [KO:K07413] [EC:1.14.14.1]
cytochrome P450 2C21-like; K07413 cytochrome P450, family 2, subfamily C [EC:1.14.14.1] [KO:K07413] [EC:1.14.14.1]
EPHX2; epoxide hydrolase 2, cytoplasmic [KO:K08726] [EC:3.1.3.76 3.3.2.10]
ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
Compound
C00157  
Phosphatidylcholine
C00219  
Arachidonate
C00427  
Prostaglandin H2
C00584  
Prostaglandin E2
C00639  
Prostaglandin F2alpha
C00696  
Prostaglandin D2
C00909  
Leukotriene A4
C01312  
Prostaglandin I2
C02165  
Leukotriene B4
C02166  
Leukotriene C4
C02198  
Thromboxane A2
C03577  
20-Hydroxyleukotriene E4
C04577  
15-OxoETE
C04742  
(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04805  
5(S)-HETE
C04822  
8(R)-HPETE
C04853  
20-OH-Leukotriene B4
C05356  
5(S)-HPETE
C05949  
12-Keto-leukotriene B4
C05950  
20-COOH-Leukotriene B4
C05951  
Leukotriene D4
C05952  
Leukotriene E4
C05953  
Prostaglandin A2
C05954  
Prostaglandin B2
C05955  
Prostaglandin C2
C05956  
Prostaglandin G2
C05957  
Prostaglandin J2
C05958  
delta-12-Prostaglandin J2
C05959  
11-epi-Prostaglandin F2alpha
C05960  
15-Keto-prostaglandin F2alpha
C05961  
6-Keto-prostaglandin F1alpha
C05962  
6-Keto-prostaglandin E1
C05963  
Thromboxane B2
C05964  
11-Dehydro-thromboxane B2
C05965  
12(S)-HPETE
C05966  
15(S)-HPETE
C06314  
Lipoxin A4
C06315  
Lipoxin B4
C06462  
Leukotriene F4
C13809  
9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  
15-Deoxy-delta-12,14-PGJ2
C14732  
5-OxoETE
C14748  
20-HETE
C14749  
19(S)-HETE
C14768  
5,6-EET
C14769  
8,9-EET
C14770  
11,12-EET
C14771  
14,15-EET
C14772  
5,6-DHET
C14773  
8,9-DHET
C14774  
11,12-DHET
C14775  
14,15-DHET
C14776  
8(S)-HETE
C14777  
12(S)-HETE
C14778  
16(R)-HETE
C14779  
9(S)-HETE
C14780  
11(R)-HETE
C14781  
15H-11,12-EETA
C14782  
11,12,15-THETA
C14794  
2,3-Dinor-8-iso prostaglandin F2alpha
C14795  
2,3-Dinor-8-iso prostaglandin F1alpha
C14807  
12-OxoETE
C14808  
Hepoxilin A3
C14809  
Trioxilin A3
C14810  
Hepoxilin B3
C14811  
Trioxilin B3
C14812  
12(R)-HPETE
C14813  
11H-14,15-EETA
C14814  
11,14,15-THETA
C14815  
5,6-Epoxytetraene
C14820  
11(R)-HPETE
C14821  
9(S)-HPETE
C14822  
12(R)-HETE
C14823  
8(S)-HPETE
C14824  
8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
KO pathway
 

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