KEGG   PATHWAY: ecb04510
Entry
ecb04510                    Pathway                                
Name
Focal adhesion - Equus caballus (horse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ecb04510  Focal adhesion
ecb04510

Other DBs
GO: 0005925
Organism
Equus caballus (horse) [GN:ecb]
Gene
100033877  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100051715  COL1A2; collagen alpha-2(I) chain [KO:K06236]
791241  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
100062160  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100066148  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100060112  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100054545  COL4A5; collagen alpha-5(IV) chain isoform X5 [KO:K06237]
100066264  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100037402  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100055332  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100066356  COL6A3; collagen alpha-3(VI) chain isoform X3 [KO:K06238]
100050035  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100064285  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
100064145  collagen alpha-4(VI) chain-like [KO:K06238]
100064173  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
100058660  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100057208  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100009713  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100059860  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
100073067  LAMA2; laminin subunit alpha-2 isoform X3 [KO:K05637]
791238  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
100058057  LAMA5; laminin subunit alpha-5 [KO:K06240]
100066875  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
100060360  LAMB1; laminin subunit beta-1 [KO:K05636]
100053539  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100056564  LAMB3; laminin subunit beta-3 [KO:K06244]
100060434  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100055269  LAMC1; laminin subunit gamma-1 [KO:K05635]
791245  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
100069663  LAMC3; laminin subunit gamma-3 [KO:K06247]
100147607  CHAD; chondroadherin [KO:K06248]
100058621  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100063449  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100073261  THBS4; thrombospondin-4 [KO:K04659]
100050044  THBS2; thrombospondin-2 precursor [KO:K04659]
100033911  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
100034189  FN1; fibronectin isoform X1 [KO:K05717]
100053029  SPP1; osteopontin [KO:K06250]
100059034  VTN; vitronectin [KO:K06251]
100061556  TNN; tenascin-N isoform X3 [KO:K06252]
100061691  TNR; tenascin-R isoform X1 [KO:K06252]
100049835  TNC; tenascin isoform X1 [KO:K06252]
100059315  TNXB; tenascin-X isoform X7 [KO:K06252]
100059472  VWF; von Willebrand factor precursor [KO:K03900]
100052979  IBSP; bone sialoprotein 2 [KO:K06253]
100063434  ITGA1; integrin alpha-1 precursor [KO:K06480]
100063367  ITGA2; integrin alpha-2 [KO:K06481]
100009697  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100056202  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100067886  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100064056  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100058756  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100056217  ITGA8; integrin alpha-8 [KO:K06584]
100054374  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100065205  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
100065211  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100051679  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100070376  ITGB5; integrin beta-5 [KO:K06588]
100051266  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100063747  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
100053462  ITGB8; integrin beta-8 [KO:K06591]
100051255  EMP2; epithelial membrane protein 2 [KO:K26256]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100055238  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100051349  PGF; placenta growth factor isoform X1 [KO:K16859]
100050877  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100060890  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100033957  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
100066773  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100063668  EMP1; epithelial membrane protein 1 [KO:K26255]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100065944  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100056199  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100072186  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100147688  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100051591  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
100065012  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
100055199  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100060444  MYL10; myosin regulatory light chain 10 [KO:K12756]
100051370  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
100062440  myosin regulatory light chain 12B [KO:K12757]
111771616  myosin regulatory light chain 12B-like [KO:K12757]
100065683  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100060501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100063928  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X15 [KO:K12329]
100056559  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100070482  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100053698  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100050092  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100050520  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100059655  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
111774175  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100050202  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100055184  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100053070  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100066343  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100054133  TLN2; talin-2 isoform X1 [KO:K06271]
100055501  TLN1; talin-1 isoform X3 [KO:K06271]
100071760  FLNC; filamin-C isoform X1 [KO:K04437]
100058256  FLNA; filamin-A isoform X1 [KO:K04437]
100057963  FLNB; filamin-B isoform X1 [KO:K04437]
100053811  PXN; paxillin isoform X1 [KO:K05760]
100070066  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
100147478  ZYX; zyxin [KO:K06273]
100070851  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100064165  VCL; vinculin isoform X1 [KO:K05700]
100050839  PARVB; beta-parvin [KO:K06275]
100071481  PARVA; alpha-parvin [KO:K06275]
100050914  PARVG; gamma-parvin isoform X1 [KO:K06275]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100055241  CTNNB1; catenin beta-1 [KO:K02105]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100060183  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100054315  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
100067000  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100051415  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100071463  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100068908  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100050855  CRKL; crk-like protein [KO:K04438]
100055697  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
100069527  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X8 [KO:K06277]
100049912  ras-related protein Rap-1A [KO:K04353]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100055975  CAV1; caveolin-1 [KO:K06278]
100071136  CAV2; caveolin-2 [KO:K12958]
100058881  CAV3; caveolin-3 [KO:K12959]
102149085  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100063053  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100146209  SHC2; SHC-transforming protein 2 [KO:K17447]
100061926  SHC3; SHC-transforming protein 3 [KO:K17448]
100055699  SHC4; SHC-transforming protein 4 [KO:K17449]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100051150  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100066590  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
100061273  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100068894  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
100060870  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ecb04010  MAPK signaling pathway
ecb04060  Cytokine-cytokine receptor interaction
ecb04070  Phosphatidylinositol signaling system
ecb04110  Cell cycle
ecb04151  PI3K-Akt signaling pathway
ecb04310  Wnt signaling pathway
ecb04512  ECM-receptor interaction
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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