KEGG   PATHWAY: ecb04612
Entry
ecb04612                    Pathway                                
Name
Antigen processing and presentation - Equus caballus (horse)
Class
Organismal Systems; Immune system
Pathway map
ecb04612  Antigen processing and presentation
ecb04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Equus caballus (horse) [GN:ecb]
Gene
100034181  IFNG; interferon gamma precursor [KO:K04687]
100033834  TNF; tumor necrosis factor [KO:K03156]
100051789  PSME1; proteasome activator complex subunit 1 [KO:K06696]
100051729  PSME2; proteasome activator complex subunit 2 [KO:K06697]
100065788  PSME3; proteasome activator complex subunit 3 isoform X2 [KO:K06698]
100050827  HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
100051595  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100050904  heat shock 70 kDa protein 1-like [KO:K03283]
100009679  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111769297  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
100629616  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
100072809  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100034150  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100033837  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100056062  MHC class I antigen 9.2 precursor [KO:K06751]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100054114  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100051657  7-51 putative nonclassical MHC class I antigen precursor [KO:K06751]
100057920  HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100056182  HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100049798  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751]
100050473  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
100050706  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100053918  HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751]
100054397  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100054448  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
100056309  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
100056099  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100056231  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100059994  HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751]
100060096  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
100067235  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
100067402  CANX; calnexin [KO:K08054]
100034203  B2M; beta-2-microglobulin precursor [KO:K08055]
100056198  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100064107  CALR; calreticulin [KO:K08057]
100062428  calreticulin [KO:K08057]
100061515  TAPBP; tapasin [KO:K08058]
100060845  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100052423  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100066774  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
100052855  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
111772100  uncharacterized protein LOC111772100 [KO:K10784]
106783094  uncharacterized protein LOC106783094 [KO:K10785]
100034224  KIR3DL; killer cell immunoglobulin-like receptor with three domains and long cytoplasmic tail precursor [KO:K07980]
100062846  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
100062823  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
100062618  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
100062789  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
106780861  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
106783293  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
100062688  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
100062540  KLRD1; natural killer cells antigen CD94 [KO:K06516]
100070878  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
100053265  LGMN; legumain isoform X1 [KO:K01369] [EC:3.4.22.34]
100060963  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100061035  HLA class II histocompatibility antigen, DM alpha chain-like precursor [KO:K06752]
100060770  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100052249  DQA; MHC class II DQ-alpha precursor [KO:K06752]
100052310  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052364  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100051944  DRA; MHC class II DR alpha chain precursor [KO:K06752]
100052184  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
100061127  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100060996  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100052006  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052125  DQA; MHC class II DQ-alpha chain precursor [KO:K06752]
100060531  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100052063  DQA; MHC class II DQ-alpha chain [KO:K06752]
100060320  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
111767457  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100060697  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100071644  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
100061234  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
100061532  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100054948  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
100052502  CD4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
100056546  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
100055472  RFX5; DNA-binding protein RFX5 [KO:K08061]
100069652  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100054237  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
100034044  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
100053895  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ecb03050  Proteasome
ecb04650  Natural killer cell mediated cytotoxicity
ecb04660  T cell receptor signaling pathway
KO pathway
ko04612   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (88)   
   KEGG GENES (88)   
All databases (89)   

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