KEGG   PATHWAY: ece02020Help
Entry
ece02020                    Pathway                                

Name
Two-component system - Escherichia coli O157:H7 EDL933 (EHEC)
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Two-component system
ece02020

All organismsOrtholog table
Module
PhoR-PhoB (phosphate starvation response) two-component regulatory system [PATH:ece02020]
PhoQ-PhoP (magnesium transport) two-component regulatory system [PATH:ece02020]
EnvZ-OmpR (osmotic stress response) two-component regulatory system [PATH:ece02020]
RstB-RstA two-component regulatory system [PATH:ece02020]
CpxA-CpxR (envelope stress response) two-component regulatory system [PATH:ece02020]
CreC-CreB (phosphate regulation) two-component regulatory system [PATH:ece02020]
BaeS-BaeR (envelope stress response) two-component regulatory system [PATH:ece02020]
BasS-BasR (antimicrobial peptide resistance) two-component regulatory system [PATH:ece02020]
CusS-CusR (copper tolerance) two-component regulatory system [PATH:ece02020]
QseC-QseB (quorum sensing) two-component regulatory system [PATH:ece02020]
KdpD-KdpE (potassium transport) two-component regulatory system [PATH:ece02020]
TorS-TorR (TMAO respiration) two-component regulatory system [PATH:ece02020]
ArcB-ArcA (anoxic redox control) two-component regulatory system [PATH:ece02020]
NarX-NarL (nitrate respiration) two-component regulatory system [PATH:ece02020]
NarQ-NarP (nitrate respiration) two-component regulatory system [PATH:ece02020]
UhpB-UhpA (hexose phosphates uptake) two-component regulatory system [PATH:ece02020]
RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system [PATH:ece02020]
BarA-UvrY (central carbon metabolism) two-component regulatory system [PATH:ece02020]
EvgS-EvgA (acid and drug tolerance) two-component regulatory system [PATH:ece02020]
CitA-CitB (citrate fermentation) two-component regulatory system [PATH:ece02020]
DcuS-DcuR (C4-dicarboxylate metabolism) two-component regulatory system [PATH:ece02020]
GlnL-GlnG (nitrogen regulation) two-component regulatory system [PATH:ece02020]
HydH-HydG (metal tolerance) two-component regulatory system [PATH:ece02020]
GlrK-GlrR (amino sugar metabolism) two-component regulatory system [PATH:ece02020]
Multidrug resistance, efflux pump AcrAD-TolC [PATH:ece02020]
Multidrug resistance, efflux pump MdtABC [PATH:ece02020]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli O157:H7 EDL933 (EHEC) [GN:ece]
Gene
Z0498  
phoR; phosphate regulon sensor protein [KO:K07636] [EC:2.7.13.3]
Z0497  
phoB; transcriptional regulator PhoB [KO:K07657]
Z0479  
phoA; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
Z4788  
hypothetical protein; K02040 phosphate transport system substrate-binding protein [KO:K02040]
Z4789  
hypothetical protein; K02040 phosphate transport system substrate-binding protein [KO:K02040]
Z5219  
pstS; phosphate ABC transporter substrate-binding protein [KO:K02040]
Z1858  
phoQ; sensor protein PhoQ [KO:K07637] [EC:2.7.13.3]
Z1859  
phoP; DNA-binding transcriptional regulator PhoP [KO:K07660]
Z4321  
PagC-like membrane protein; K07804 putatice virulence related protein PagC [KO:K07804]
Z4759  
envZ; osmolarity sensor protein [KO:K07638] [EC:2.7.13.3]
Z4760  
ompR; osmolarity response regulator [KO:K07659]
Z3473  
ompC; porin [KO:K09475]
Z1276  
ompF; outer membrane protein F [KO:K09476]
Z2610  
rstB; sensor protein RstB [KO:K07639] [EC:2.7.13.3]
Z2609  
rstA; DNA-binding transcriptional regulator RstA [KO:K07661]
Z5456  
cpxA; two-component sensor protein [KO:K07640] [EC:2.7.13.3]
Z5457  
cpxR; DNA-binding transcriptional regulator CpxR [KO:K07662]
Z0173  
htrA; serine endoprotease [KO:K04771] [EC:3.4.21.107]
Z6002  
creC; sensory histidine kinase CreC [KO:K07641] [EC:2.7.13.3]
Z6001  
creB; DNA-binding response regulator CreB [KO:K07663]
Z3247  
baeS; signal transduction histidine-protein kinase BaeS [KO:K07642] [EC:2.7.13.3]
Z3248  
baeR; DNA-binding transcriptional regulator BaeR [KO:K07664]
Z3243  
multidrug efflux system subunit MdtA; K07799 putative multidrug efflux transporter MdtA [KO:K07799]
Z3244  
yegN; multidrug efflux system subunit MdtB [KO:K07788]
Z3245  
yegO; multidrug efflux system subunit MdtC [KO:K07789]
Z3246  
yegB; multidrug efflux system protein MdtE [KO:K18326]
Z3727  
acrD; aminoglycoside/multidrug efflux system [KO:K18324]
Z5714  
basS; sensor protein BasS/PmrB [KO:K07643] [EC:2.7.13.3]
Z5715  
basR; DNA-binding transcriptional regulator BasR [KO:K07771]
Z3511  
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; K07806 UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87] [KO:K07806] [EC:2.6.1.87]
Z0708  
ybcZ; sensor kinase CusS [KO:K07644] [EC:2.7.13.3]
Z0709  
ylcA; DNA-binding transcriptional activator CusR [KO:K07665]
Z0711  
ylcB; copper/silver efflux system outer membrane protein CusC [KO:K07796]
Z0712  
ylcC; copper-binding protein [KO:K07810]
Z0713  
ylcD; copper/silver efflux system membrane fusion protein CusB [KO:K07798]
Z0714  
ybdE; inner membrane component for iron transport [KO:K07787]
Z4378  
qseC; sensor protein QseC [KO:K07645] [EC:2.7.13.3]
Z4377  
qseB; DNA-binding transcriptional regulator QseB [KO:K07666]
Z2946  
flhD; transcriptional activator FlhD [KO:K02403]
Z2945  
flhC; transcriptional activator FlhC [KO:K02402]
Z3013  
fliC; flagellin [KO:K02406]
Z3012  
fliA; flagellar biosynthesis sigma factor [KO:K02405]
Z2944  
motA; flagellar motor protein MotA [KO:K02556]
Z0842  
kdpD; sensor protein KdpD [KO:K07646] [EC:2.7.13.3]
Z0841  
kdpE; DNA-binding transcriptional activator KdpE [KO:K07667]
Z0845  
kdpA; potassium-transporting ATPase subunit A [KO:K01546] [EC:3.6.3.12]
Z0844  
kdpB; potassium-transporting ATPase subunit B [KO:K01547] [EC:3.6.3.12]
Z0843  
kdpC; potassium-transporting ATPase subunit C [KO:K01548] [EC:3.6.3.12]
Z1410  
torS; hybrid sensory histidine kinase TorS [KO:K07647] [EC:2.7.13.3]
Z1412  
torR; DNA-binding transcriptional regulator TorR [KO:K07772]
Z1414  
torC; trimethylamine N-oxide reductase [KO:K03532]
Z1415  
torA; trimethylamine N-oxide reductase subunit [KO:K07811] [EC:1.7.2.3]
Z1416  
torD; chaperone protein TorD [KO:K03533]
Z4574  
arcB; aerobic respiration control sensor protein ArcB [KO:K07648] [EC:2.7.13.3]
Z6004  
arcA; two-component response regulator [KO:K07773]
Z5193  
dnaA; chromosome replication initiator DnaA [KO:K02313]
Z2222  
D-alanyl-D-alanine dipeptidase; K08641 D-alanyl-D-alanine dipeptidase [EC:3.4.13.22] [KO:K08641] [EC:3.4.13.22]
Z0764  
citA; sensor-type protein [KO:K07700] [EC:2.7.13.3]
Z0765  
dpiA; two-component response regulator DpiA [KO:K07702]
Z0762  
citC; citrate lyase synthetase [KO:K01910] [EC:6.2.1.22]
Z0761  
citD; citrate lyase subunit gamma [KO:K01646]
Z0760  
citE; citrate lyase subunit beta [KO:K01644] [EC:4.1.3.34]
Z0759  
citF; citrate lyase subunit alpha [KO:K01643] [EC:2.8.3.10]
Z0758  
citX; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase [KO:K05964] [EC:2.7.7.61]
Z0757  
citG; triphosphoribosyl-dephospho-CoA synthase [KO:K05966] [EC:2.4.2.52]
Z0756  
ybdS; hypothetical protein [KO:K09477]
Z5727  
yjdH; sensory histidine kinase DcuS [KO:K07701] [EC:2.7.13.3]
Z5726  
yjdG; DNA-binding transcriptional activator DcuR [KO:K07703]
Z5725  
dcuB; anaerobic C4-dicarboxylate transporter [KO:K07792]
Z2231  
sfcA; malate dehydrogenase [KO:K00027] [EC:1.1.1.38]
Z1998  
narX; nitrate/nitrite sensor protein NarX [KO:K07673] [EC:2.7.13.3]
Z1996  
narL; transcriptional regulator NarL [KO:K07684]
Z3726  
narQ; nitrate/nitrite sensor protein NarQ [KO:K07674] [EC:2.7.13.3]
Z3450  
narP; transcriptional regulator NarP [KO:K07685]
Z2001  
narG; nitrate reductase 1 subunit alpha [KO:K00370] [EC:1.7.99.4]
Z2244  
narZ; cryptic nitrate reductase 2 subunit alpha [KO:K00370] [EC:1.7.99.4]
Z2002  
narH; nitrate reductase 1 subunit beta [KO:K00371] [EC:1.7.99.4]
Z2245  
narY; cryptic nitrate reductase 2 subunit beta [KO:K00371] [EC:1.7.99.4]
Z2003  
narJ; nitrate reductase 1, delta subunit, assembly function [KO:K00373]
Z2246  
narW; cryptic nitrate reductase 2 subunit delta [KO:K00373]
Z2004  
narI; nitrate reductase 1, cytochrome b(NR), gamma subunit [KO:K00374] [EC:1.7.99.4]
Z2247  
narV; cryptic nitrate reductase 2 subunit gamma [KO:K00374] [EC:1.7.99.4]
Z2236  
fdnG; formate dehydrogenase-N, nitrate-inducible, alpha subunit [KO:K08348] [EC:1.1.5.6]
Z2235  
fdnH; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit [KO:K08349]
Z2234  
fdnI; formate dehydrogenase-N subunit gamma [KO:K08350]
Z5762  
frdA; fumarate reductase flavoprotein subunit [KO:K00244] [EC:1.3.5.4]
Z5760  
frdB; fumarate reductase iron-sulfur subunit [KO:K00245] [EC:1.3.5.4]
Z5759  
frdC; fumarate reductase subunit C [KO:K00246]
Z5758  
frdD; fumarate reductase subunit D [KO:K00247]
Z0461  
permease; hexosephosphate transport [KO:K07783]
Z5157  
uhpC; regulatory protein UhpC [KO:K07783]
Z5158  
uhpB; sensory histidine kinase UhpB [KO:K07675] [EC:2.7.13.3]
Z0462  
sensor kinase; K07675 two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] [KO:K07675] [EC:2.7.13.3]
Z5159  
uhpA; DNA-binding transcriptional activator UhpA [KO:K07686]
Z0463  
response regulator; hexosephosphate transport [KO:K07686]
Z5156  
uhpT; sugar phosphate antiporter [KO:K07784]
Z0208  
rcsF; outer membrane lipoprotein [KO:K06080]
Z3477  
rcsC; hybrid sensory kinase in two-component regulatory system with RcsB and YojN [KO:K07677] [EC:2.7.13.3]
Z3475  
yojN; phosphotransfer intermediate protein in two-component regulatory system with RcsBC [KO:K07676] [EC:2.7.13.3]
Z3041  
rcsA; positive regulator for ctr capsule biosynthesis, positive transcription factor [KO:K07781]
Z3476  
rcsB; transcriptional regulator RcsB [KO:K07687]
Z4101  
barA; hybrid sensory histidine kinase BarA [KO:K07678] [EC:2.7.13.3]
Z3002  
uvrY; response regulator [KO:K07689]
Z3004  
sdiA; DNA-binding transcriptional activator SdiA [KO:K07782]
Z3998  
csrA; carbon storage regulator [KO:K03563]
Z3632  
evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA [KO:K07679] [EC:2.7.13.3]
Z3631  
evgA; DNA-binding transcriptional activator EvgA [KO:K07690]
Z3630  
emrK; multidrug resistance protein K [KO:K07797]
Z3629  
emrY; multidrug resistance protein Y [KO:K07786]
Z0693  
fimZ; transcriptional regulator FimZ [KO:K07688]
Z5757  
ampC; beta-lactamase [KO:K01467] [EC:3.5.2.6]
Z0177  
glnD; PII uridylyl-transferase [KO:K00990] [EC:2.7.7.59]
Z3829  
glnB; nitrogen regulatory protein P-II 1 [KO:K04751]
Z5405  
glnL; nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
Z5404  
glnG; nitrogen regulation protein NR(I) [KO:K07712]
Z5406  
glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
Z5579  
hydH; sensor protein ZraS [KO:K07709] [EC:2.7.13.3]
Z5580  
hydG; transcriptional regulatory protein ZraR [KO:K07713]
Z5578  
zraP; zinc resistance protein [KO:K07803]
Z4164  
yqeF; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Z4942  
dctA; C4-dicarboxylate transporter DctA [KO:K11103]
Z4565  
rpoN; RNA polymerase factor sigma-54 [KO:K03092]
Z3833  
yfhK; 2-component sensor protein [KO:K07711] [EC:2.7.13.3]
Z3830  
yfhA; 2-component transcriptional regulator [KO:K07715]
Z2938  
cheR; chemotaxis methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
Z5955  
tsr; methyl-accepting chemotaxis protein I, serine sensor receptor [KO:K05874]
Z2940  
tar; methyl-accepting chemotaxis protein II [KO:K05875]
Z2300  
trg; methyl-accepting chemotaxis protein III, ribose sensor receptor [KO:K05876]
Z2939  
tap; methyl-accepting protein IV [KO:K05877]
Z4425  
aer; aerotaxis sensor receptor, flavoprotein [KO:K03776]
Z2941  
cheW; purine-binding chemotaxis protein [KO:K03408]
Z2942  
cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
Z2936  
cheY; chemotaxis regulatory protein CheY [KO:K03413]
Z2937  
cheB; chemotaxis-specific methylesterase [KO:K03412] [EC:3.1.1.61]
Z0802  
gltL; glutamate/aspartate ABC transporter ATP-binding protein [KO:K10004] [EC:3.6.3.-]
Z0803  
gltK; glutamate/aspartate transport system permease [KO:K10002]
Z0804  
gltJ; glutamate/aspartate transport system permease [KO:K10003]
Z0805  
ybeJ; glutamate and aspartate transporter subunit [KO:K10001]
Z4718  
crp; cAMP-regulatory protein [KO:K10914]
Z0900  
cydA; cytochrome d terminal oxidase, polypeptide subunit I [KO:K00425] [EC:1.10.3.-]
Z1395  
appC; third cytochrome oxidase, subunit I [KO:K00425] [EC:1.10.3.-]
Z0901  
cydB; cytochrome d terminal oxidase polypeptide subunit II [KO:K00426] [EC:1.10.3.-]
Z1396  
appB; third cytochrome oxidase, subunit II [KO:K00426] [EC:1.10.3.-]
Compound
C00007  
Oxygen
C00009  
Orthophosphate
C00025  
L-Glutamate
C00031  
D-Glucose
C00034  
Manganese
C00036  
Oxaloacetate
C00038  
Zinc cation
C00042  
Succinate
C00049  
L-Aspartate
C00064  
L-Glutamine
C00070  
Copper
C00088  
Nitrite
C00092  
D-Glucose 6-phosphate
C00122  
Fumarate
C00149  
(S)-Malate
C00158  
Citrate
C00164  
Acetoacetate
C00238  
Potassium cation
C00244  
Nitrate
C00291  
Nickel
C00305  
Magnesium cation
C00399  
Ubiquinone
C00547  
L-Noradrenaline
C00697  
Nitrogen
C00788  
L-Adrenaline
C00828  
Menaquinone
C01104  
Trimethylamine N-oxide
C01667  
Bacitracin
C02084  
Tetrathionate
C05818  
2-Demethylmenaquinone
C06689  
Vancomycin
C06696  
Lead
C11612  
Polymyxin B
C11842  
N-(3-(S)-Hydroxybutyryl)homoserine lactone
C12008  
Ramoplanin A2
C14819  
Fe3+
C16421  
AI-2
C16463  
3',5'-Cyclic diGMP
C16640  
CAI-1
C16665  
12-Methyltetradecanoic acid
C18206  
cis-11-Methyl-2-dodecenoic acid
D07746  
Colistin (INN)
D08401  
Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
Reference
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
Reference
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
Reference
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
Reference
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
Reference
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
Reference
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
Reference
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
Reference
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
Reference
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
Reference
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
Reference
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
Reference
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
Reference
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
Reference
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
Reference
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
Reference
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
Reference
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
Reference
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
Reference
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
Reference
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
Reference
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
Reference
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
Reference
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
Reference
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
Reference
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
Reference
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
Reference
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
Reference
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
Reference
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
Reference
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
Reference
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
Reference
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
Reference
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
Reference
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
Reference
PMID:14523104 (Staphylococcus)
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
Reference
PMID:17981963 (Pseudomonas)
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
Reference
PMID:18455986 (Caulobacter)
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
Reference
PMID:15101991 (Pseudomonas)
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
Reference
PMID:15170479 (Synechocystis)
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
Reference
PMID:12039966 (Synechocystis)
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
Reference
PMID:12417709 (Synechocystis)
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
Reference
PMID:15273097 (Bacillus)
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
Reference
PMID:15856219 (Bacillus)
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
Reference
PMID:15941986 (Bacillus)
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
Reference
PMID:12890034 (Bacillus)
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
Reference
PMID:17322186 (Bacillus)
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
Reference
PMID:10972810 (Bacillus)
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
Reference
PMID:15995196 (Bacillus)
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
Reference
PMID:12949160 (Bacillus)
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
Reference
PMID:12949159 (Bacillus)
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
Reference
PMID:10708364 (Bacillus)
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
Reference
PMID:8455557 (Rhodobacter)
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
Reference
PMID:9287004 (Rhodobacter)
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
Reference
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
Reference
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
Reference
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
Reference
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III.  Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
Reference
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
Reference
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
Reference
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
Reference
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
Reference
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
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