KEGG   PATHWAY: ece02020Help
Entry
ece02020                    Pathway                                

Name
Two-component system - Escherichia coli O157:H7 EDL933 (EHEC)
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Two-component system
ece02020

All organismsOrtholog table
Module
PhoR-PhoB (phosphate starvation response) two-component regulatory system [PATH:ece02020]
PhoQ-PhoP (magnesium transport) two-component regulatory system [PATH:ece02020]
EnvZ-OmpR (osmotic stress response) two-component regulatory system [PATH:ece02020]
RstB-RstA two-component regulatory system [PATH:ece02020]
CpxA-CpxR (envelope stress response) two-component regulatory system [PATH:ece02020]
CreC-CreB (phosphate regulation) two-component regulatory system [PATH:ece02020]
BaeS-BaeR (envelope stress response) two-component regulatory system [PATH:ece02020]
BasS-BasR (antimicrobial peptide resistance) two-component regulatory system [PATH:ece02020]
CusS-CusR (copper tolerance) two-component regulatory system [PATH:ece02020]
QseC-QseB (quorum sensing) two-component regulatory system [PATH:ece02020]
KdpD-KdpE (potassium transport) two-component regulatory system [PATH:ece02020]
TorS-TorR (TMAO respiration) two-component regulatory system [PATH:ece02020]
ArcB-ArcA (anoxic redox control) two-component regulatory system [PATH:ece02020]
NarX-NarL (nitrate respiration) two-component regulatory system [PATH:ece02020]
NarQ-NarP (nitrate respiration) two-component regulatory system [PATH:ece02020]
UhpB-UhpA (hexose phosphates uptake) two-component regulatory system [PATH:ece02020]
RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system [PATH:ece02020]
BarA-UvrY (central carbon metabolism) two-component regulatory system [PATH:ece02020]
EvgS-EvgA (acid and drug tolerance) two-component regulatory system [PATH:ece02020]
CitA-CitB (citrate fermentation) two-component regulatory system [PATH:ece02020]
DcuS-DcuR (C4-dicarboxylate metabolism) two-component regulatory system [PATH:ece02020]
GlnL-GlnG (nitrogen regulation) two-component regulatory system [PATH:ece02020]
HydH-HydG (metal tolerance) two-component regulatory system [PATH:ece02020]
GlrK-GlrR (amino sugar metabolism) two-component regulatory system [PATH:ece02020]
Multidrug resistance, efflux pump AcrAD-TolC [PATH:ece02020]
Multidrug resistance, efflux pump MdtABC [PATH:ece02020]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli O157:H7 EDL933 (EHEC) [GN:ece]
Gene
Z0498  
phoR; positive and negative sensor protein for pho regulon [KO:K07636] [EC:2.7.13.3]
Z0497  
phoB; positive response regulator for pho regulon, sensor is PhoR (or CreC) [KO:K07657]
Z0479  
phoA; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
Z4788  
orf; hypothetical protein [KO:K02040]
Z4789  
orf; hypothetical protein [KO:K02040]
Z5219  
pstS; high-affinity phosphate-specific transport system [KO:K02040]
Z1858  
phoQ; sensor protein PhoQ [KO:K07637] [EC:2.7.13.3]
Z1859  
phoP; transcriptional regulatory protein [KO:K07660]
Z4321  
putative PagC-like membrane protein; K07804 putatice virulence related protein PagC [KO:K07804]
Z4759  
envZ; protein histidine kinase/phosphatase sensor for OmpR, modulates expression of ompF and ompC [KO:K07638] [EC:2.7.13.3]
Z4760  
ompR; response regulator (sensor, EnvZ) affecting transcription of ompC and ompF: outer membrane protein synthesis [KO:K07659]
Z3473  
ompC; outer membrane protein 1b (Ib [KO:K09475]
Z1276  
ompF; outer membrane protein 1a (Ia [KO:K09476]
Z2610  
rstB; sensor histidine protein kinase (RstA regulator) [KO:K07639] [EC:2.7.13.3]
Z2609  
rstA; response transcriptional regulatory protein (RstB sensor) [KO:K07661]
Z5456  
cpxA; probable sensor protein (histidine protein kinase), acting on arcA [KO:K07640] [EC:2.7.13.3]
Z5457  
cpxR; transcriptional regulator in 2-component system [KO:K07662]
Z0173  
htrA; periplasmic serine protease Do [KO:K04771] [EC:3.4.21.107]
Z6002  
creC; catabolite repression sensor kinase for PhoB [KO:K07641] [EC:2.7.13.3]
Z6001  
creB; catabolic regulation response regulator [KO:K07663]
Z3247  
baeS; sensor protein (for BaeR) [KO:K07642] [EC:2.7.13.3]
Z3248  
baeR; transcriptional response regulatory protein (sensor BaeS) [KO:K07664]
Z3243  
putative membrane protein; K07799 membrane fusion protein, multidrug efflux system [KO:K07799]
Z3244  
yegN; orf, hypothetical protein [KO:K07788]
Z3245  
yegO; orf, hypothetical protein [KO:K07789]
Z3246  
yegB; putative transport protein [KO:K18326]
Z3727  
acrD; sensitivity to acriflavine, integral membrane protein, possible efflux pump [KO:K18324]
Z5714  
basS; sensor protein for basR [KO:K07643] [EC:2.7.13.3]
Z5715  
basR; transcriptional regulatory protein 2-component regulatory system member [KO:K07771]
Z3511  
putative enzyme; K07806 UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87] [KO:K07806] [EC:2.6.1.87]
Z0708  
ybcZ; putative 2-component sensor protein [KO:K07644] [EC:2.7.13.3]
Z0709  
ylcA; putative 2-component transcriptional regulator [KO:K07665]
Z0711  
ylcB; putative resistance protein [KO:K07796]
Z0712  
ylcC; orf, hypothetical protein [KO:K07810]
Z0713  
ylcD; putative resistance protein [KO:K07798]
Z0714  
ybdE; putative inner membrane component for iron transport [KO:K07787]
Z4378  
qseC; quorum sensing Escherichia coli regulator C [KO:K07645] [EC:2.7.13.3]
Z4377  
qseB; quorum sensing Escherichia coli regulator B [KO:K07666]
Z2946  
flhD; regulator of flagellar biosynthesis, acting on class 2 operons [KO:K02403]
Z2945  
flhC; regulator of flagellar biosynthesis acting on class 2 operons [KO:K02402]
Z3013  
fliC; flagellar biosynthesis [KO:K02406]
Z3012  
fliA; flagellar biosynthesis [KO:K02405]
Z2944  
motA; proton conductor component of motor [KO:K02556]
Z0842  
kdpD; sensor for high-affinity potassium transport system [KO:K07646] [EC:2.7.13.3]
Z0841  
kdpE; regulator of kdp operon (transcriptional effector) [KO:K07667]
Z0845  
kdpA; ATPase of high-affinity potassium transport system, A chain [KO:K01546] [EC:3.6.3.12]
Z0844  
kdpB; ATPase of high-affinity potassium transport system, B chain [KO:K01547] [EC:3.6.3.12]
Z0843  
kdpC; high-affinity potassium transport system [KO:K01548] [EC:3.6.3.12]
Z1410  
torS; sensor protein torS (regulator TorR) [KO:K07647] [EC:2.7.13.3]
Z1412  
torR; response transcriptional regulator for torA (sensor TorS) [KO:K07772]
Z1414  
torC; trimethylamine N-oxide reductase, cytochrome c-type subunit [KO:K03532]
Z1415  
torA; trimethylamine N-oxide reductase subunit [KO:K07811] [EC:1.7.2.3]
Z1416  
torD; part of trimethylamine-N-oxide oxidoreductase [KO:K03533]
Z4574  
arcB; aerobic respiration sensor-response protein [KO:K07648] [EC:2.7.13.3]
Z6004  
arcA; negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA) [KO:K07773]
Z5193  
dnaA; DNA biosynthesis [KO:K02313]
Z2222  
orf; K08641 D-alanyl-D-alanine dipeptidase [EC:3.4.13.22] [KO:K08641] [EC:3.4.13.22]
Z0724  
fepA; outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D [KO:K19611]
Z0764  
citA; putative sensor-type protein [KO:K07700] [EC:2.7.13.3]
Z0765  
citB; sequence similarity to Shigella regulator [KO:K07702]
Z0762  
citC; citrate lyase synthetase (citrate (pro-3S)-lyase ligase [KO:K01910] [EC:6.2.1.22]
Z0761  
citD; citrate lyase acyl carrier protein (gamma chain) [KO:K01646]
Z0760  
citE; citrate lyase beta chain (acyl lyase subunit) [KO:K01644] [EC:4.1.3.34]
Z0759  
citF; citrate lyase alpha chain [KO:K01643] [EC:2.8.3.10]
Z0758  
ybdU; orf, hypothetical protein [KO:K05964] [EC:2.7.7.61]
Z0757  
citG; orf, hypothetical protein [KO:K05966] [EC:2.4.2.52]
Z0756  
ybdS; putative a membrane protein [KO:K09477]
Z5727  
yjdH; putative 2-component sensor protein [KO:K07701] [EC:2.7.13.3]
Z5726  
yjdG; putative 2-component transcriptional regulator [KO:K07703]
Z5725  
dcuB; anaerobic dicarboxylate transport [KO:K07792]
Z2231  
sfcA; NAD-linked malate dehydrogenase (malic enzyme) [KO:K00027] [EC:1.1.1.38]
Z1998  
narX; nitrate/nitrate sensor, histidine protein kinase acts on NarL regulator [KO:K07673] [EC:2.7.13.3]
Z1996  
narL; pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes [KO:K07684]
Z3726  
narQ; sensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL) [KO:K07674] [EC:2.7.13.3]
Z3450  
narP; nitrate/nitrite response regulator (sensor NarQ) [KO:K07685]
Z2001  
narG; nitrate reductase 1, alpha subunit [KO:K00370] [EC:1.7.99.4 1.7.5.1]
Z2244  
narZ; cryptic nitrate reductase 2, alpha subunit [KO:K00370] [EC:1.7.99.4 1.7.5.1]
Z2002  
narH; nitrate reductase 1, beta subunit [KO:K00371] [EC:1.7.99.4 1.7.5.1]
Z2245  
narY; cryptic nitrate reductase 2, beta subunit [KO:K00371] [EC:1.7.99.4 1.7.5.1]
Z2003  
narJ; nitrate reductase 1, delta subunit, assembly function [KO:K00373]
Z2246  
narW; cryptic nitrate reductase 2, delta subunit, assembly function [KO:K00373]
Z2004  
narI; nitrate reductase 1, cytochrome b(NR), gamma subunit [KO:K00374] [EC:1.7.99.4 1.7.5.1]
Z2247  
narV; cryptic nitrate reductase 2, gamma subunit [KO:K00374] [EC:1.7.99.4 1.7.5.1]
Z2236  
fdnG; formate dehydrogenase-N, nitrate-inducible, alpha subunit [KO:K08348] [EC:1.1.5.6]
Z2235  
fdnH; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit [KO:K08349]
Z2234  
fdnI; formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit [KO:K08350]
Z5762  
frdA; fumarate reductase, anaerobic, flavoprotein subunit [KO:K00244] [EC:1.3.5.4]
Z5760  
frdB; fumarate reductase, anaerobic, iron-sulfur protein subunit [KO:K00245] [EC:1.3.5.4]
Z5759  
frdC; fumarate reductase, anaerobic, membrane anchor polypeptide [KO:K00246]
Z5758  
frdD; fumarate reductase, anaerobic, membrane anchor polypeptide [KO:K00247]
Z0461  
putative permease; hexosephosphate transport [KO:K07783]
Z5157  
uhpC; regulator of uhpT [KO:K07783]
Z5158  
uhpB; sensor histidine protein kinase phosphorylates UhpA [KO:K07675] [EC:2.7.13.3]
Z0462  
putative sensor kinase; hexosephosphate transport [KO:K07675] [EC:2.7.13.3]
Z5159  
uhpA; response regulator, positive activator of uhpT transcription (sensor, uhpB) [KO:K07686]
Z0463  
putative response regulator; hexosephosphate transport [KO:K07686]
Z5156  
uhpT; hexose phosphate transport protein [KO:K07784]
Z0208  
rcsF; regulator in colanic acid synthesis [KO:K06080]
Z3477  
rcsC; sensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB [KO:K07677] [EC:2.7.13.3]
Z3475  
yojN; putative 2-component sensor protein [KO:K07676] [EC:2.7.13.3]
Z3041  
rcsA; positive regulator for ctr capsule biosynthesis, positive transcription factor [KO:K07781]
Z3476  
rcsB; positive response regulator for colanic capsule biosynthesis, (sensor, RcsC) [KO:K07687]
Z4101  
barA; sensor-regulator, activates OmpR by phophorylation [KO:K07678] [EC:2.7.13.3]
Z3002  
uvrY; putative 2-component transcriptional regulator [KO:K07689]
Z3004  
sdiA; transcriptional regulator of ftsQAZ gene cluster [KO:K07782]
Z3998  
csrA; carbon storage regulator [KO:K03563]
Z3632  
evgS; putative sensor for regulator EvgA [KO:K07679] [EC:2.7.13.3]
Z3631  
evgA; putative positive transcription regulator (sensor EvgS) [KO:K07690]
Z3630  
emrK; multidrug resistance protein K [KO:K07797]
Z3629  
emrY; multidrug resistance protein Y [KO:K07786]
Z0693  
fimZ; fimbrial Z protein [KO:K07688]
Z5757  
ampC; beta-lactamase [KO:K01467] [EC:3.5.2.6]
Z0177  
glnD; protein PII [KO:K00990] [EC:2.7.7.59]
Z3829  
glnB; regulatory protein P-II for glutamine synthetase [KO:K04751]
Z5405  
glnL; histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII) [KO:K07708] [EC:2.7.13.3]
Z5404  
glnG; response regulator for gln (sensor glnL) (nitrogen regulator I, NRI) [KO:K07712]
Z5406  
glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
Z5579  
hydH; sensor kinase for HydG, hydrogenase 3 activity [KO:K07709] [EC:2.7.13.3]
Z5580  
hydG; response regulator of hydrogenase 3 activity (sensor HydH) [KO:K07713]
Z5578  
yjaI; orf, hypothetical protein [KO:K07803]
Z4164  
yqeF; putative acyltransferase [KO:K00626] [EC:2.3.1.9]
Z4942  
dctA; uptake of C4-dicarboxylic acids [KO:K11103]
Z4565  
rpoN; RNA polymerase, sigma(54 or 60) factor [KO:K03092]
Z3833  
qseE; quorum sensing regulator E [KO:K07711] [EC:2.7.13.3]
Z3830  
qseF; quorum sensing regulator F [KO:K07715]
Z1391  
hyaC; probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit [KO:K03620]
Z2938  
cheR; response regulator for chemotaxis [KO:K00575] [EC:2.1.1.80]
Z5955  
tsr; methyl-accepting chemotaxis protein I, serine sensor receptor [KO:K05874]
Z2940  
tar; methyl-accepting chemotaxis protein II, aspartate sensor receptor [KO:K05875]
Z2300  
trg; methyl-accepting chemotaxis protein III, ribose sensor receptor [KO:K05876]
Z2939  
tap; methyl-accepting chemotaxis protein IV, peptide sensor receptor [KO:K05877]
Z4425  
aer; aerotaxis sensor receptor, flavoprotein [KO:K03776]
Z2941  
cheW; positive regulator of CheA protein activity [KO:K03408]
Z2942  
cheA; sensory transducer kinase between chemo-signal receptors and CheB and CheY [KO:K03407] [EC:2.7.13.3]
Z2936  
cheY; chemotaxis regulator transmits chemoreceptor signals to flagelllar motor components [KO:K03413]
Z2937  
cheB; response regulator for chemotaxis (cheA sensor) [KO:K03412] [EC:3.1.1.61]
Z0802  
gltL; ATP-binding protein of glutamate/aspartate transport system [KO:K10004] [EC:3.6.3.-]
Z0803  
gltK; glutamate/aspartate transport system permease [KO:K10002]
Z0804  
gltJ; glutamate/aspartate transport system permease [KO:K10003]
Z0805  
ybeJ; putative periplasmic binding transport protein [KO:K10001]
Z4718  
crp; cyclic AMP receptor protein [KO:K10914]
Z0900  
cydA; cytochrome d terminal oxidase, polypeptide subunit I [KO:K00425] [EC:1.10.3.-]
Z1395  
appC; probable third cytochrome oxidase, subunit I [KO:K00425] [EC:1.10.3.-]
Z0901  
cydB; cytochrome d terminal oxidase polypeptide subunit II [KO:K00426] [EC:1.10.3.-]
Z1396  
appB; probable third cytochrome oxidase, subunit II [KO:K00426] [EC:1.10.3.-]
Z4392  
tolC; outer membrane channel [KO:K12340]
Compound
C00007  
Oxygen
C00009  
Orthophosphate
C00025  
L-Glutamate
C00031  
D-Glucose
C00034  
Manganese
C00036  
Oxaloacetate
C00038  
Zinc cation
C00042  
Succinate
C00049  
L-Aspartate
C00064  
L-Glutamine
C00070  
Copper
C00088  
Nitrite
C00092  
D-Glucose 6-phosphate
C00122  
Fumarate
C00149  
(S)-Malate
C00158  
Citrate
C00164  
Acetoacetate
C00238  
Potassium cation
C00244  
Nitrate
C00282  
Hydrogen
C00291  
Nickel
C00305  
Magnesium cation
C00399  
Ubiquinone
C00547  
L-Noradrenaline
C00697  
Nitrogen
C00788  
L-Adrenaline
C00828  
Menaquinone
C01104  
Trimethylamine N-oxide
C01667  
Bacitracin
C02084  
Tetrathionate
C05757  
(R)-3-Hydroxydodecanoyl-[acp]
C05818  
2-Demethylmenaquinone
C06230  
Fe-enterobactin
C06689  
Vancomycin
C06696  
Lead
C11612  
Polymyxin B
C11842  
N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  
3-Hydroxy-palmitic acid methyl ester
C12008  
Ramoplanin A2
C13768  
Colistin sulfate
C14819  
Fe3+
C16421  
AI-2
C16463  
3',5'-Cyclic diGMP
C16640  
CAI-1
C16665  
12-Methyltetradecanoic acid
C18206  
cis-11-Methyl-2-dodecenoic acid
D07746  
Colistin (INN)
D08401  
Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
Reference
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
Reference
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
Reference
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
Reference
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
Reference
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
Reference
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
Reference
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
Reference
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
Reference
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
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