KEGG   PATHWAY: ecm03440Help
Entry
ecm03440                    Pathway                                

Name
Homologous recombination - Escherichia coli SMS-3-5 (environmental)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ecm03440  Homologous recombination
ecm03440

Ortholog table
Module
ecm_M00260  DNA polymerase III complex, bacteria [PATH:ecm03440]
Other DBs
BSID: 65734
GO: 0000724
Organism
Escherichia coli SMS-3-5 (environmental) [GN:ecm]
Gene
EcSMS35_3025  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
EcSMS35_4521  ssb2; single-stranded DNA-binding protein [KO:K03111]
EcSMS35_A0056  ssb1; plasmid-derived single-stranded DNA-binding protein [KO:K03111]
EcSMS35_4065  recF; DNA replication and repair protein RecF [KO:K03629]
EcSMS35_2718  recO; DNA repair protein RecO [KO:K03584]
EcSMS35_0515  recR; recombination protein RecR [KO:K06187]
EcSMS35_2822  recA; protein RecA [KO:K03553]
EcSMS35_4246  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EcSMS35_1325  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
EcSMS35_1326  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
EcSMS35_1323  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
EcSMS35_3987  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
EcSMS35_2967  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
EcSMS35_2969  recC; exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
EcSMS35_2966  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
EcSMS35_0195  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
EcSMS35_4066  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
EcSMS35_0513  dnaX; DNA polymerase III, tau subunit [KO:K02343] [EC:2.7.7.7]
EcSMS35_0660  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
EcSMS35_2028  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
EcSMS35_0229  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
EcSMS35_1345  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
EcSMS35_4739  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
EcSMS35_4919  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
EcSMS35_4377  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
EcSMS35_0510  priC; primosomal replication protein N'' [KO:K04067]
EcSMS35_4907  dnaT; primosomal protein 1 [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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