KEGG   PATHWAY: eco00730Help
Entry
eco00730                    Pathway                                

Name
Thiamine metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Metabolism of cofactors and vitamins
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Thiamine metabolism
eco00730

All organismsOrtholog table
Module
Thiamine biosynthesis, AIR => thiamine-P/thiamine-2P [PATH:eco00730]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b3994  
thiC; phosphomethylpyrimidine synthase [KO:K03147] [EC:4.1.99.17]
b2103  
thiD; bifunctional hydroxy-methylpyrimidine kinase/hydroxy-phosphomethylpyrimidine kinase [KO:K00941] [EC:2.7.4.7 2.7.1.49]
b3992  
thiF; adenylyltransferase, modifies ThiS C-terminus [KO:K03148] [EC:2.7.7.73]
b2530  
iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent [KO:K04487] [EC:2.8.1.7]
b0423  
thiI; tRNA s(4)U8 sulfurtransferase [KO:K03151]
b3990  
thiH; tyrosine lyase, involved in thiamine-thiazole moiety synthesis [KO:K03150] [EC:4.1.99.19]
b0420  
dxs; 1-deoxyxylulose-5-phosphate synthase, thiamine triphosphate-binding, FAD-requiring [KO:K01662] [EC:2.2.1.7]
b3991  
thiG; thiamine biosynthesis ThiGH complex subunit [KO:K03149] [EC:2.8.1.10]
b2104  
thiM; hydoxyethylthiazole kinase [KO:K00878] [EC:2.7.1.50]
b3993  
thiE; thiamine phosphate synthase (thiamine phosphate pyrophosphorylase) [KO:K00788] [EC:2.5.1.3]
b0417  
thiL; thiamine monophosphate kinase [KO:K00946] [EC:2.7.4.16]
b1106  
thiK; thiamine kinase [KO:K07251] [EC:2.7.1.89]
Compound
C00003  
NAD+
C00018  
Pyridoxal phosphate
C00022  
Pyruvate
C00037  
Glycine
C00068  
Thiamin diphosphate
C00082  
L-Tyrosine
C00097  
L-Cysteine
C00118  
D-Glyceraldehyde 3-phosphate
C00378  
Thiamine
C01081  
Thiamin monophosphate
C01279  
4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02691  
Heteropyrithiamine
C02892  
Thiamine acetic acid
C03028  
Thiamin triphosphate
C03373  
Aminoimidazole ribotide
C04294  
5-(2-Hydroxyethyl)-4-methylthiazole
C04327  
4-Methyl-5-(2-phosphoethyl)thiazole
C04556  
4-Amino-2-methyl-5-phosphomethylpyrimidine
C04752  
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
C05856  
Thiamine aldehyde
C11437  
1-Deoxy-D-xylulose 5-phosphate
C15809  
Iminoglycine
C15810  
C15811  
[Enzyme]-cysteine
C15812  
[Enzyme]-S-sulfanylcysteine
C15813  
C15814  
C20246  
2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  
2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20784  
ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
Reference
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
Reference
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
Reference
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
KO pathway
 

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