KEGG   PATHWAY: eco02020Help
Entry
eco02020                    Pathway                                

Name
Two-component system - Escherichia coli K-12 MG1655
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Two-component system
eco02020

All organismsOrtholog table
Module
PhoR-PhoB (phosphate starvation response) two-component regulatory system [PATH:eco02020]
PhoQ-PhoP (magnesium transport) two-component regulatory system [PATH:eco02020]
EnvZ-OmpR (osmotic stress response) two-component regulatory system [PATH:eco02020]
RstB-RstA two-component regulatory system [PATH:eco02020]
CpxA-CpxR (envelope stress response) two-component regulatory system [PATH:eco02020]
CreC-CreB (phosphate regulation) two-component regulatory system [PATH:eco02020]
BaeS-BaeR (envelope stress response) two-component regulatory system [PATH:eco02020]
BasS-BasR (antimicrobial peptide resistance) two-component regulatory system [PATH:eco02020]
CusS-CusR (copper tolerance) two-component regulatory system [PATH:eco02020]
QseC-QseB (quorum sensing) two-component regulatory system [PATH:eco02020]
KdpD-KdpE (potassium transport) two-component regulatory system [PATH:eco02020]
TorS-TorR (TMAO respiration) two-component regulatory system [PATH:eco02020]
ArcB-ArcA (anoxic redox control) two-component regulatory system [PATH:eco02020]
NarX-NarL (nitrate respiration) two-component regulatory system [PATH:eco02020]
NarQ-NarP (nitrate respiration) two-component regulatory system [PATH:eco02020]
UhpB-UhpA (hexose phosphates uptake) two-component regulatory system [PATH:eco02020]
RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system [PATH:eco02020]
BarA-UvrY (central carbon metabolism) two-component regulatory system [PATH:eco02020]
EvgS-EvgA (acid and drug tolerance) two-component regulatory system [PATH:eco02020]
CitA-CitB (citrate fermentation) two-component regulatory system [PATH:eco02020]
DcuS-DcuR (C4-dicarboxylate metabolism) two-component regulatory system [PATH:eco02020]
GlnL-GlnG (nitrogen regulation) two-component regulatory system [PATH:eco02020]
HydH-HydG (metal tolerance) two-component regulatory system [PATH:eco02020]
AtoS-AtoC (cPHB biosynthesis) two-component regulatory system [PATH:eco02020]
GlrK-GlrR (amino sugar metabolism) two-component regulatory system [PATH:eco02020]
Multidrug resistance, efflux pump AcrAD-TolC [PATH:eco02020]
Multidrug resistance, efflux pump MdtABC [PATH:eco02020]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b0400  
phoR; sensory histidine kinase in two-component regulatory system with PhoB [KO:K07636] [EC:2.7.13.3]
b0399  
phoB; response regulator in two-component regulatory system with PhoR (or CreC) [KO:K07657]
b0383  
phoA; bacterial alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
b3728  
pstS; periplasmic phosphate binding protein, high-affinity [KO:K02040]
b1129  
phoQ; sensory histidine kinase in two-component regulatory system with PhoP [KO:K07637] [EC:2.7.13.3]
b1130  
phoP; response regulator in two-component regulatory system with PhoQ [KO:K07660]
b3404  
envZ; sensory histidine kinase in two-component regulatory system with OmpR [KO:K07638] [EC:2.7.13.3]
b3405  
ompR; response regulator in two-component regulatory system with EnvZ [KO:K07659]
b2215  
ompC; outer membrane porin protein C [KO:K09475]
b0929  
ompF; outer membrane porin 1a (Ia [KO:K09476]
b1609  
rstB; sensory histidine kinase of RstAB two-component system, low Mg-responsive via PhoQP [KO:K07639] [EC:2.7.13.3]
b1608  
rstA; response regulator of RstAB two-component system, low Mg-responsive via PhoQP [KO:K07661]
b3911  
cpxA; sensory histidine kinase in two-component regulatory system with CpxR [KO:K07640] [EC:2.7.13.3]
b3912  
cpxR; response regulator in two-component regulatory system with CpxA [KO:K07662]
b0161  
degP; serine endoprotease (protease Do), membrane-associated [KO:K04771] [EC:3.4.21.107]
b4399  
creC; sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon [KO:K07641] [EC:2.7.13.3]
b4398  
creB; response regulator in two-component regulatory system with CreC [KO:K07663]
b2078  
baeS; sensory histidine kinase in two-component regulatory system with BaeR [KO:K07642] [EC:2.7.13.3]
b2079  
baeR; response regulator in two-component regulatory system with BaeS [KO:K07664]
b2074  
mdtA; multidrug efflux system, subunit A [KO:K07799]
b2075  
mdtB; multidrug efflux system, subunit B [KO:K07788]
b2076  
mdtC; multidrug efflux system, subunit C [KO:K07789]
b2077  
mdtD; putative arabinose efflux transporter [KO:K18326]
b2470  
acrD; aminoglycoside/multidrug efflux system [KO:K18324]
b4112  
basS; sensory histidine kinase in two-component regulatory system with BasR [KO:K07643] [EC:2.7.13.3]
b4113  
basR; response regulator in two-component regulatory system with BasS [KO:K07771]
b2253  
arnB; uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent [KO:K07806] [EC:2.6.1.87]
b0570  
cusS; sensory histidine kinase in two-component regulatory system with CusR, senses copper ions [KO:K07644] [EC:2.7.13.3]
b0571  
cusR; response regulator in two-component regulatory system with CusS [KO:K07665]
b0572  
cusC; copper/silver efflux system, outer membrane component [KO:K07796]
b0573  
cusF; periplasmic copper- and silver-binding protein [KO:K07810]
b0574  
cusB; copper/silver efflux system, membrane fusion protein [KO:K07798]
b0575  
cusA; copper/silver efflux system, membrane component [KO:K07787]
b3026  
qseC; quorum sensing sensory histidine kinase in two-component regulatory system with QseB [KO:K07645] [EC:2.7.13.3]
b3025  
qseB; quorum sensing DNA-binding response regulator in two-component regulatory system with QseC [KO:K07666]
b1892  
flhD; flagellar class II regulon transcriptional activator, with FlhC [KO:K02403]
b1891  
flhC; flagellar class II regulon transcriptional activator, with FlhD [KO:K02402]
b1923  
fliC; flagellar filament structural protein (flagellin) [KO:K02406]
b1922  
fliA; RNA polymerase, sigma 28 (sigma F) factor [KO:K02405]
b1890  
motA; proton conductor component of flagella motor [KO:K02556]
b0695  
kdpD; fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein [KO:K07646] [EC:2.7.13.3]
b0694  
kdpE; response regulator in two-component regulatory system with KdpD [KO:K07667]
b0698  
kdpA; potassium translocating ATPase, subunit A [KO:K01546] [EC:3.6.3.12]
b0697  
kdpB; potassium translocating ATPase, subunit B [KO:K01547] [EC:3.6.3.12]
b0696  
kdpC; potassium translocating ATPase, subunit C [KO:K01548] [EC:3.6.3.12]
b4513  
kdpF; potassium ion accessory transporter subunit [KO:K01545]
b0993  
torS; hybrid sensory histidine kinase in two-component regulatory system with TorR [KO:K07647] [EC:2.7.13.3]
b0995  
torR; response regulator in two-component regulatory system with TorS [KO:K07772]
b0996  
torC; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit [KO:K03532]
b0997  
torA; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit [KO:K07811] [EC:1.7.2.3]
b0998  
torD; TorA-maturation chaperone [KO:K03533]
b3210  
arcB; aerobic respiration control sensor histidine protein kinase, cognate to two-component response regulators ArcA and RssB [KO:K07648] [EC:2.7.13.3]
b4401  
arcA; response regulator in two-component regulatory system with ArcB or CpxA [KO:K07773]
b3702  
dnaA; chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator [KO:K02313]
b1488  
ddpX; D-ala-D-ala dipeptidase, Zn-dependent [KO:K08641] [EC:3.4.13.22]
b0619  
citA; sensory histidine kinase in two-component regulatory system with CitB [KO:K07700] [EC:2.7.13.3]
b0620  
citB; response regulator in two-component regulatory system with CitA [KO:K07702]
b0618  
citC; [citrate [pro-3S]-lyase] ligase [KO:K01910] [EC:6.2.1.22]
b0617  
citD; citrate lyase, acyl carrier (gamma) subunit [KO:K01646]
b0616  
citE; citrate lyase, citryl-ACP lyase (beta) subunit [KO:K01644] [EC:4.1.3.34]
b0615  
citF; citrate lyase, citrate-ACP transferase (alpha) subunit [KO:K01643] [EC:2.8.3.10]
b0614  
citX; apo-citrate lyase phosphoribosyl-dephospho-CoA transferase [KO:K05964] [EC:2.7.7.61]
b0613  
citG; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase [KO:K05966] [EC:2.4.2.52]
b0612  
citT; citrate:succinate antiporter [KO:K09477]
b0564  
appY; global transcriptional activator [KO:K07780]
b4125  
dcuS; sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration [KO:K07701] [EC:2.7.13.3]
b4124  
dcuR; response regulator in two-component regulatory system with DcuS [KO:K07703]
b4123  
dcuB; C4-dicarboxylate transporter, anaerobic [KO:K07792]
b1479  
maeA; malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme) [KO:K00027] [EC:1.1.1.38]
b1222  
narX; sensory histidine kinase in two-component regulatory system with NarL [KO:K07673] [EC:2.7.13.3]
b1221  
narL; response regulator in two-component regulatory system with NarX (or NarQ) [KO:K07684]
b2469  
narQ; sensory histidine kinase in two-component regulatory system with NarP (NarL) [KO:K07674] [EC:2.7.13.3]
b2193  
narP; response regulator in two-component regulatory system with NarQ or NarX [KO:K07685]
b1224  
narG; nitrate reductase 1, alpha subunit [KO:K00370] [EC:1.7.99.4]
b1468  
narZ; nitrate reductase 2 (NRZ), alpha subunit [KO:K00370] [EC:1.7.99.4]
b1225  
narH; nitrate reductase 1, beta (Fe-S) subunit [KO:K00371] [EC:1.7.99.4]
b1467  
narY; nitrate reductase 2 (NRZ), beta subunit [KO:K00371] [EC:1.7.99.4]
b1226  
narJ; molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 [KO:K00373]
b1466  
narW; nitrate reductase 2 (NRZ), delta subunit (assembly subunit) [KO:K00373]
b1227  
narI; nitrate reductase 1, gamma (cytochrome b(NR)) subunit [KO:K00374] [EC:1.7.99.4]
b1465  
narV; nitrate reductase 2 (NRZ), gamma subunit [KO:K00374] [EC:1.7.99.4]
b1474  
fdnG; formate dehydrogenase-N, alpha subunit, nitrate-inducible [KO:K08348] [EC:1.1.5.6]
b1475  
fdnH; formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [KO:K08349]
b1476  
fdnI; formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible [KO:K08350]
b4154  
frdA; fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit [KO:K00244] [EC:1.3.5.4]
b4153  
frdB; fumarate reductase (anaerobic), Fe-S subunit [KO:K00245] [EC:1.3.5.4]
b4152  
frdC; fumarate reductase (anaerobic), membrane anchor subunit [KO:K00246]
b4151  
frdD; fumarate reductase (anaerobic), membrane anchor subunit [KO:K00247]
b3667  
uhpC; membrane protein regulates uhpT expression [KO:K07783]
b3668  
uhpB; sensory histidine kinase in two-component regulatory sytem with UhpA [KO:K07675] [EC:2.7.13.3]
b3669  
uhpA; response regulator in two-component regulatory system wtih UhpB [KO:K07686]
b3666  
uhpT; hexose phosphate transporter [KO:K07784]
b0196  
rcsF; putative outer membrane protein [KO:K06080]
b2218  
rcsC; hybrid sensory kinase in two-component regulatory system with RcsB and YojN [KO:K07677] [EC:2.7.13.3]
b2216  
rcsD; phosphotransfer intermediate protein in two-component regulatory system with RcsBC [KO:K07676] [EC:2.7.13.3]
b1951  
rcsA; transcriptional regulator of colanic acid capsular biosynthesis [KO:K07781]
b2217  
rcsB; response regulator in two-component regulatory system with RcsC and YojN [KO:K07687]
b2786  
barA; hybrid sensory histidine kinase, in two-component regulatory system with UvrY [KO:K07678] [EC:2.7.13.3]
b1914  
uvrY; response regulator in two-component regulatory system with BarA [KO:K07689]
b1916  
sdiA; quorum-sensing transcriptional activator [KO:K07782]
b2696  
csrA; pleiotropic regulatory protein for carbon source metabolism [KO:K03563]
b2370  
evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA [KO:K07679] [EC:2.7.13.3]
b2369  
evgA; response regulator in two-component regulatory system with EvgS [KO:K07690]
b2368  
emrK; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component [KO:K07797]
b2367  
emrY; putative multidrug efflux system [KO:K07786]
b0535  
sfmZ; response regulator family protein [KO:K07688]
b4150  
ampC; penicillin-binding protein [KO:K01467] [EC:3.5.2.6]
b0167  
glnD; uridylyltransferase [KO:K00990] [EC:2.7.7.59]
b2553  
glnB; regulatory protein P-II for glutamine synthetase [KO:K04751]
b3869  
glnL; sensory histidine kinase in two-component regulatory system with GlnG [KO:K07708] [EC:2.7.13.3]
b3868  
glnG; fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein [KO:K07712]
b3870  
glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
b4003  
zraS; sensory histidine kinase in two-component regulatory system with ZraR [KO:K07709] [EC:2.7.13.3]
b4004  
zraR; fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator/sigma54 interaction protein [KO:K07713]
b4002  
zraP; Zn-dependent periplasmic chaperone [KO:K07803]
b2219  
atoS; sensory histidine kinase in two-component regulatory system with AtoC [KO:K07710] [EC:2.7.13.3]
b2220  
atoC; fused response regulator of ato operon, in two-component system with AtoS: response regulator/sigma54 interaction protein [KO:K07714]
b2221  
atoD; acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit [KO:K01034] [EC:2.8.3.9 2.8.3.8]
b2222  
atoA; acetyl-CoA:acetoacetyl-CoA transferase, beta subunit [KO:K01035] [EC:2.8.3.9 2.8.3.8]
b2223  
atoE; short chain fatty acid transporter [KO:K02106]
b2224  
atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
b2844  
yqeF; short chain acyltransferase [KO:K00626] [EC:2.3.1.9]
b3528  
dctA; C4-dicarboxylic acid, orotate and citrate transporter [KO:K11103]
b3202  
rpoN; RNA polymerase, sigma 54 (sigma N) factor [KO:K03092]
b2556  
glrK; sensor protein kinase regulating glmY sRNA in two-component system with response regulator GlrR [KO:K07711] [EC:2.7.13.3]
b2554  
glrR; response regulator regulating glmY sRNA in two-component system with sensor protein GlrK [KO:K07715]
b4441  
glmY; sRNA activator of glmS mRNA, glmZ processing antagonist [KO:K15841]
b1884  
cheR; chemotaxis regulator, protein-glutamate methyltransferase [KO:K00575] [EC:2.1.1.80]
b4355  
tsr; methyl-accepting chemotaxis protein I, serine sensor receptor [KO:K05874]
b1886  
tar; methyl-accepting chemotaxis protein II [KO:K05875]
b1421  
trg; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor [KO:K05876]
b1885  
tap; methyl-accepting protein IV [KO:K05877]
b3072  
aer; fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component [KO:K03776]
b1887  
cheW; purine-binding chemotaxis protein [KO:K03408]
b1888  
cheA; fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY: sensory histidine kinase/signal sensing protein [KO:K03407] [EC:2.7.13.3]
b1882  
cheY; chemotaxis regulator transmitting signal to flagellar motor component [KO:K03413]
b1883  
cheB; fused chemotaxis regulator: protein-glutamate methylesterase in two-component regulatory system with CheA [KO:K03412] [EC:3.1.1.61]
b0652  
gltL; glutamate, aspartate ABC transporter ATP-binding subunit [KO:K10004] [EC:3.6.3.-]
b0653  
gltK; glutamate, aspartate ABC transporter permease subunit [KO:K10002]
b0654  
gltJ; glutamate, aspartate ABC transporter permease subunit [KO:K10003]
b0655  
gltI; glutamate, aspartate binding protein, periplasmic [KO:K10001]
b3357  
crp; cAMP-activated global transcription factor, mediator of catabolite repression [KO:K10914]
b0733  
cydA; cytochrome d terminal oxidase, subunit I [KO:K00425] [EC:1.10.3.-]
b0978  
cbdA; cytochrome bd-II oxidase, subunit I [KO:K00425] [EC:1.10.3.-]
b0734  
cydB; cytochrome d terminal oxidase, subunit II [KO:K00426] [EC:1.10.3.-]
b0979  
cbdB; cytochrome bd-II oxidase, subunit II [KO:K00426] [EC:1.10.3.-]
Compound
C00007  
Oxygen
C00009  
Orthophosphate
C00025  
L-Glutamate
C00031  
D-Glucose
C00034  
Manganese
C00036  
Oxaloacetate
C00038  
Zinc cation
C00042  
Succinate
C00049  
L-Aspartate
C00064  
L-Glutamine
C00070  
Copper
C00088  
Nitrite
C00092  
D-Glucose 6-phosphate
C00122  
Fumarate
C00149  
(S)-Malate
C00158  
Citrate
C00164  
Acetoacetate
C00238  
Potassium cation
C00244  
Nitrate
C00291  
Nickel
C00305  
Magnesium cation
C00399  
Ubiquinone
C00547  
L-Noradrenaline
C00697  
Nitrogen
C00788  
L-Adrenaline
C00828  
Menaquinone
C01104  
Trimethylamine N-oxide
C01667  
Bacitracin
C02084  
Tetrathionate
C05818  
2-Demethylmenaquinone
C06689  
Vancomycin
C06696  
Lead
C11612  
Polymyxin B
C11842  
N-(3-(S)-Hydroxybutyryl)homoserine lactone
C12008  
Ramoplanin A2
C14819  
Fe3+
C16421  
AI-2
C16463  
3',5'-Cyclic diGMP
C16640  
CAI-1
C16665  
12-Methyltetradecanoic acid
C18206  
cis-11-Methyl-2-dodecenoic acid
D07746  
Colistin (INN)
D08401  
Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
Reference
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
Reference
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
Reference
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
Reference
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
Reference
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
Reference
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
Reference
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
Reference
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
Reference
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
Reference
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
Reference
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
Reference
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
Reference
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
Reference
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
Reference
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
Reference
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
Reference
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
Reference
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
Reference
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
Reference
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
Reference
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
Reference
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
Reference
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
Reference
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
Reference
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
Reference
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
Reference
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
Reference
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
Reference
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
Reference
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
Reference
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
Reference
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
Reference
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
Reference
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
Reference
PMID:14523104 (Staphylococcus)
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
Reference
PMID:17981963 (Pseudomonas)
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
Reference
PMID:18455986 (Caulobacter)
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
Reference
PMID:15101991 (Pseudomonas)
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
Reference
PMID:15170479 (Synechocystis)
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
Reference
PMID:12039966 (Synechocystis)
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
Reference
PMID:12417709 (Synechocystis)
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
Reference
PMID:15273097 (Bacillus)
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
Reference
PMID:15856219 (Bacillus)
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
Reference
PMID:15941986 (Bacillus)
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
Reference
PMID:12890034 (Bacillus)
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
Reference
PMID:17322186 (Bacillus)
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
Reference
PMID:10972810 (Bacillus)
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
Reference
PMID:15995196 (Bacillus)
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
Reference
PMID:12949160 (Bacillus)
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
Reference
PMID:12949159 (Bacillus)
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
Reference
PMID:10708364 (Bacillus)
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
Reference
PMID:8455557 (Rhodobacter)
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
Reference
PMID:9287004 (Rhodobacter)
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
Reference
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
Reference
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
Reference
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
Reference
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III.  Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
Reference
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
Reference
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
Reference
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
Reference
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
Reference
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
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