KEGG   PATHWAY: eco02030Help
Entry
eco02030                    Pathway                                

Name
Bacterial chemotaxis - Escherichia coli K-12 MG1655
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
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Pathway map
Bacterial chemotaxis
eco02030

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GO: 
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b4355  
tsr; methyl-accepting chemotaxis protein I, serine sensor receptor [KO:K05874]
b1886  
tar; methyl-accepting chemotaxis protein II [KO:K05875]
b1421  
trg; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor [KO:K05876]
b1885  
tap; methyl-accepting protein IV [KO:K05877]
b3072  
aer; fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component [KO:K03776]
b4034  
malE; maltose transporter subunit [KO:K10108]
b3751  
rbsB; D-ribose transporter subunit [KO:K10439]
b2150  
mglB; methyl-galactoside transporter subunit [KO:K10540]
b3544  
dppA; dipeptide transporter [KO:K12368]
b1294  
sapA; antimicrobial peptide transport ABC transporter periplasmic binding protein [KO:K12368]
b1888  
cheA; fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY: sensory histidine kinase/signal sensing protein [KO:K03407] [EC:2.7.13.3]
b1887  
cheW; purine-binding chemotaxis protein [KO:K03408]
b1882  
cheY; chemotaxis regulator transmitting signal to flagellar motor component [KO:K03413]
b1881  
cheZ; chemotaxis regulator, protein phosphatase for CheY [KO:K03414]
b1883  
cheB; fused chemotaxis regulator: protein-glutamate methylesterase in two-component regulatory system with CheA [KO:K03412] [EC:3.1.1.61]
b1884  
cheR; chemotaxis regulator, protein-glutamate methyltransferase [KO:K00575] [EC:2.1.1.80]
b1939  
fliG; flagellar motor switching and energizing component [KO:K02410]
b1945  
fliM; flagellar motor switching and energizing component [KO:K02416]
b1946  
fliN; flagellar motor switching and energizing component [KO:K02417]
b1890  
motA; proton conductor component of flagella motor [KO:K02556]
b1889  
motB; protein that enables flagellar motor rotation [KO:K02557]
Compound
C00049  
L-Aspartate
C00107  
Dipeptide
C00121  
D-Ribose
C00124  
D-Galactose
C00208  
Maltose
C00716  
Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
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