| Entry |
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| Name |
Nucleotide excision repair - Entamoeba dispar
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| Description |
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
| Nucleotide excision repair |
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| Module |
| DNA polymerase delta complex [PATH: edi03420] | | | | | | | | | | |
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| Other DBs |
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| Organism |
Entamoeba dispar [GN: edi]
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| Gene |
| | | RING-box protein pip1; K03868 RING-box protein 1 [KO: K03868] | | cullin-4B; K10609 cullin 4 [KO: K10609] | | DNA damage-binding protein; K10610 DNA damage-binding protein 1 [KO: K10610] | | UV excision repair protein rad23; K10839 UV excision repair protein RAD23 [KO: K10839] | | transcription regulatory protein SNF2; K10841 DNA excision repair protein ERCC-6 [KO: K10841] | | hypothetical protein; K10842 CDK-activating kinase assembly factor MAT1 [KO: K10842] | | rad25/xp-B DNA repair helicase; K10843 DNA excision repair protein ERCC-3 [EC: 3.6.4.12] [KO: K10843] [EC: 3.6.4.12] | | DNA repair helicase rad3/xp-D; K10844 DNA excision repair protein ERCC-2 [EC: 3.6.4.12] [KO: K10844] [EC: 3.6.4.12] | | TFIIH basal transcription factor complex p44 subunit; K03142 transcription initiation factor TFIIH subunit 2 [KO: K03142] | | RNA polymerase II transcription factor B subunit; K03143 transcription initiation factor TFIIH subunit 3 [KO: K03143] | | TFIIH basal transcription factor complex p52 subunit; K03144 transcription initiation factor TFIIH subunit 4 [KO: K03144] | | hypothetical protein; K10846 DNA excision repair protein ERCC-5 [KO: K10846] | | replication protein A 70 kDa DNA-binding subunit; K07466 replication factor A1 [KO: K07466] | | hypothetical protein; K10739 replication factor A2 [KO: K10739] | | DNA repair endonuclease xp-f / mei-9 / rad1; K10848 DNA excision repair protein ERCC-4 [EC:3.1.-.-] [KO: K10848] [EC:3.1.-.-] | | Mating-type switching protein swi10; K10849 DNA excision repair protein ERCC-1 [KO: K10849] | | Mating-type switching protein swi10; K10849 DNA excision repair protein ERCC-1 [KO: K10849] | | DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1 [EC: 2.7.7.7] [KO: K02327] [EC: 2.7.7.7] | | DNA polymerase delta small subunit; K02328 DNA polymerase delta subunit 2 [KO: K02328] | | proliferating cell nuclear antigen; K04802 proliferating cell nuclear antigen [KO: K04802] | | replication factor C large subunit; K10754 replication factor C subunit 1 [KO: K10754] | | replication factor C subunit; K10755 replication factor C subunit 2/4 [KO: K10755] | | replication factor C subunit; K10755 replication factor C subunit 2/4 [KO: K10755] | | replication factor C subunit; K10756 replication factor C subunit 3/5 [KO: K10756] | | replication factor C subunit; K10756 replication factor C subunit 3/5 [KO: K10756] | | |
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| Reference |
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| Authors |
Sugasawa K. |
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| Title |
[Molecular mechanism of mammalian nucleotide excision repair] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:893-901 (2001) |
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| Reference |
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| Authors |
Nakatsu Y. |
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| Title |
[Transcription-coupled repair and Cockayne syndrome] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:908-15 (2001) |
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| Reference |
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| Authors |
Nakagawa N, Masui R, Kuramitsu S. |
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| Title |
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:968-75 (2001) |
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| Reference |
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| Authors |
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ. |
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| Title |
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship. |
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| Journal |
Neuroscience 145:1388-96 (2007) |
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| Reference |
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| Authors |
Saldivar JS, Wu X, Follen M, Gershenson D. |
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| Title |
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity. |
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| Journal |
Gynecol Oncol 107:S56-71 (2007) |
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| Reference |
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| Authors |
Sugasawa K. |
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| Title |
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 51:1339-44 (2006) |
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| Reference |
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| Authors |
Ito S, Ando D, Tanaka K. |
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| Title |
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 52:1823-31 (2007) |
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| KO pathway |
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