KEGG   PATHWAY: eel03440Help
Entry
eel03440                    Pathway                                

Name
Homologous recombination - Eubacterium eligens
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
eel03440  Homologous recombination
eel03440

Ortholog table
Module
eel_M00260  DNA polymerase III complex, bacteria [PATH:eel03440]
Other DBs
BSID: 98565
GO: 0000724
Organism
Eubacterium eligens [GN:eel]
Gene
EUBELI_01389  single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
EUBELI_01955  single-strand DNA-binding protein [KO:K03111]
EUBELI_00004  DNA replication and repair protein RecF [KO:K03629]
EUBELI_01356  DNA repair protein RecO (recombination protein O) [KO:K03584]
EUBELI_02016  recombination protein RecR [KO:K06187]
EUBELI_01121  Ca2+-transporting ATPase [KO:K03553]
EUBELI_10064  recombination protein RecA [KO:K03553]
EUBELI_01072  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EUBELI_00942  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
EUBELI_00943  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
EUBELI_00959  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
EUBELI_00226  exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
EUBELI_01681  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
EUBELI_00855  DNA polymerase III subunit alpha, the Gram-positive type [KO:K03763] [EC:2.7.7.7]
EUBELI_00002  DNA polymerase [KO:K02338] [EC:2.7.7.7]
EUBELI_02018  DNA polymerase [KO:K02343] [EC:2.7.7.7]
EUBELI_01210  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
EUBELI_00026  DNA polymerase [KO:K02341] [EC:2.7.7.7]
EUBELI_00714  primosomal protein N (replication factor Y) (superfamily II helicase) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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