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elc03440                    Pathway                                

Homologous recombination - Escherichia coli clone D i14
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Pathway map
elc03440  Homologous recombination

Ortholog table
elc_M00260  DNA polymerase III complex, bacteria [PATH:elc03440]
Other DBs
BSID: 612971
GO: 0000724
Escherichia coli clone D i14 [GN:elc]
i14_3192  recJ; ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
i14_4633  ssb; single-stranded DNA-binding protein [KO:K03111]
i14_4215  recF; recombination protein F [KO:K03629]
i14_2884  recO; DNA repair protein RecO [KO:K03584]
i14_0567  recR; recombination protein RecR [KO:K06187]
i14_2984  recA; recombinase A [KO:K03553]
i14_4402  xni; exonuclease IX [KO:K02335] [EC:]
i14_2091  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:]
i14_2090  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:]
i14_2093  ruvC; Holliday junction resolvase [KO:K01159] [EC:]
i14_4139  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:]
i14_3136  recB; exonuclease V subunit beta [KO:K03582] [EC:]
i14_3138  recC; exonuclease V subunit gamma [KO:K03583] [EC:]
i14_3135  recD; exonuclease V subunit alpha [KO:K03581] [EC:]
i14_0204  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:]
i14_4216  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:]
i14_0565  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:]
i14_0700  holA; DNA polymerase III subunit delta [KO:K02340] [EC:]
i14_1253  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:]
i14_0234  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:]
i14_2070  holE; DNA polymerase III subunit theta [KO:K02345] [EC:]
i14_4863  holC; DNA polymerase III subunit chi [KO:K02339] [EC:]
i14_4967  holD; DNA polymerase III subunit psi [KO:K02344] [EC:]
i14_4480  priA; primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
i14_4793  priB; primosomal replication protein N [KO:K02686]
i14_0562  priC; primosomal replication protein N'' [KO:K04067]
i14_4957  dnaT; primosomal protein DnaI [KO:K02317]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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