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eoc03440                    Pathway                                

Homologous recombination - Escherichia coli O7:K1 CE10
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

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DNA polymerase III complex, bacteria [PATH:eoc03440]
Other DBs
Escherichia coli O7:K1 CE10 [GN:eoc]
recJ; ssDNA exonuclease, 5' --3'-specific [KO:K07462] [EC:3.1.-.-]
ssb; single-stranded DNA-binding protein [KO:K03111]
recF; gap repair protein [KO:K03629]
recO; gap repair protein [KO:K03584]
recR; gap repair protein [KO:K06187]
recA; DNA strand exchange and recombination protein with protease and nuclease activity [KO:K03553]
polA; fused DNA polymerase I 5'-3' polymerase/3'-5' exonuclease/5'-3' exonuclease [KO:K02335] [EC:]
ruvA; component of RuvABC resolvasome, regulatory subunit [KO:K03550] [EC:]
ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome [KO:K03551] [EC:]
ruvC; component of RuvABC resolvasome, endonuclease [KO:K01159] [EC:]
recG; ATP-dependent DNA helicase [KO:K03655] [EC:]
recB; exonuclease V (RecBCD complex), beta subunit [KO:K03582] [EC:]
recC; exonuclease V (RecBCD complex), gamma chain [KO:K03583] [EC:]
recD; exonuclease V (RecBCD complex), alpha chain [KO:K03581] [EC:]
dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:]
dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:]
dnaX; DNA polymerase III/DNA elongation factor III, tau and gamma subunits [KO:K02343] [EC:]
holA; DNA polymerase III, delta subunit [KO:K02340] [EC:]
holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:]
dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:]
holE; DNA polymerase III, theta subunit [KO:K02345] [EC:]
holC; DNA polymerase III, chi subunit [KO:K02339] [EC:]
holD; DNA polymerase III, psi subunit [KO:K02344] [EC:]
priA; Primosome factor n' (replication factor Y) [KO:K04066] [EC:3.6.4.-]
priC; primosomal replication protein N'' [KO:K04067]
dnaT; DNA biosynthesis protein (primosomal protein I) [KO:K02317]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
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