KEGG   PATHWAY: eoc03440Help
Entry
eoc03440                    Pathway                                

Name
Homologous recombination - Escherichia coli O7:K1 CE10
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
eoc03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:eoc03440]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli O7:K1 CE10 [GN:eoc]
Gene
K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-] | (GenBank) recJ; ssDNA exonuclease, 5' --3'-specific [KO:K07462] [EC:3.1.-.-]
K03111 single-strand DNA-binding protein | (GenBank) ssb; single-stranded DNA-binding protein [KO:K03111]
K03629 DNA replication and repair protein RecF | (GenBank) recF; gap repair protein [KO:K03629]
K03584 DNA repair protein RecO (recombination protein O) | (GenBank) recO; gap repair protein [KO:K03584]
K06187 recombination protein RecR | (GenBank) recR; gap repair protein [KO:K06187]
K03553 recombination protein RecA | (GenBank) recA; DNA strand exchange and recombination protein with protease and nuclease activity [KO:K03553]
K02335 DNA polymerase I [EC:2.7.7.7] | (GenBank) polA; fused DNA polymerase I 5'-3' polymerase/3'-5' exonuclease/5'-3' exonuclease [KO:K02335] [EC:2.7.7.7]
K03550 holliday junction DNA helicase RuvA [EC:3.6.4.12] | (GenBank) ruvA; component of RuvABC resolvasome, regulatory subunit [KO:K03550] [EC:3.6.4.12]
K03551 holliday junction DNA helicase RuvB [EC:3.6.4.12] | (GenBank) ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome [KO:K03551] [EC:3.6.4.12]
K01159 crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4] | (GenBank) ruvC; component of RuvABC resolvasome, endonuclease [KO:K01159] [EC:3.1.22.4]
K03655 ATP-dependent DNA helicase RecG [EC:3.6.4.12] | (GenBank) recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
K03582 exodeoxyribonuclease V beta subunit [EC:3.1.11.5] | (GenBank) recB; exonuclease V (RecBCD complex), beta subunit [KO:K03582] [EC:3.1.11.5]
K03583 exodeoxyribonuclease V gamma subunit [EC:3.1.11.5] | (GenBank) recC; exonuclease V (RecBCD complex), gamma chain [KO:K03583] [EC:3.1.11.5]
K03581 exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] | (GenBank) recD; exonuclease V (RecBCD complex), alpha chain [KO:K03581] [EC:3.1.11.5]
K02337 DNA polymerase III subunit alpha [EC:2.7.7.7] | (GenBank) dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
K02338 DNA polymerase III subunit beta [EC:2.7.7.7] | (GenBank) dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
K02343 DNA polymerase III subunit gamma/tau [EC:2.7.7.7] | (GenBank) dnaX; DNA polymerase III/DNA elongation factor III, tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
K02340 DNA polymerase III subunit delta [EC:2.7.7.7] | (GenBank) holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
K02341 DNA polymerase III subunit delta' [EC:2.7.7.7] | (GenBank) holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
K02342 DNA polymerase III subunit epsilon [EC:2.7.7.7] | (GenBank) dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
K02345 DNA polymerase III subunit theta [EC:2.7.7.7] | (GenBank) holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
K02339 DNA polymerase III subunit chi [EC:2.7.7.7] | (GenBank) holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
K02344 DNA polymerase III subunit psi [EC:2.7.7.7] | (GenBank) holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
K04066 primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] | (GenBank) priA; Primosome factor n' (replication factor Y) [KO:K04066] [EC:3.6.4.-]
K04067 primosomal replication protein N'' | (GenBank) priC; primosomal replication protein N'' [KO:K04067]
K02317 DNA replication protein DnaT | (GenBank) dnaT; DNA biosynthesis protein (primosomal protein I) [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

DBGET integrated database retrieval system