KEGG   PATHWAY: etw00540Help
Entry
etw00540                    Pathway                                
Name
Lipopolysaccharide biosynthesis - Escherichia coli O157:H7 TW14359 (EHEC)
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Lipopolysaccharide biosynthesis
etw00540

All organismsOrtholog table
Module
Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:etw00540]
CMP-KDO biosynthesis [PATH:etw00540]
ADP-L-glycero-D-manno-heptose biosynthesis [PATH:etw00540]
Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen [PATH:etw00540]
Other DBs
BSID: 
GO: 
Organism
Escherichia coli O157:H7 TW14359 (EHEC) [GN:etw]
Gene
lpxA; UDP-N-acetylglucosamine acyltransferase [KO:K00677] [EC:2.3.1.129]
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
lpxH; UDP-2,3-diacylglucosamine hydrolase [KO:K03269] [EC:3.6.1.54]
lpxB; lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
lpxK; tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [KO:K03270] [EC:3.1.3.45]
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
lpxL; lipid A biosynthesis lauroyl acyltransferase [KO:K02517] [EC:2.3.1.-]
lpxM; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [KO:K02560] [EC:2.3.1.-]
gmhA; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
rfaE; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [KO:K03272] [EC:2.7.7.70 2.7.1.167]
gmhB; D,D-heptose 1,7-bisphosphate phosphatase [KO:K03273] [EC:3.1.3.83 3.1.3.82]
rfaD; ADP-L-glycero-D-manno-heptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
rfaC; ADP-heptose:LPS heptosyl transferase I [KO:K02841] [EC:2.4.-.-]
rfaF; ADP-heptose:LPS heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
rfaG; glucosyltransferase I [KO:K02844] [EC:2.4.1.-]
waaY; lipopolysaccharide core biosynthesis protein [KO:K02850] [EC:2.7.1.-]
waaP; kinase that phosphorylates core heptose of lipopolysaccharide [KO:K02848] [EC:2.7.1.-]
lipopolysaccharide core biosynthesis protein; K02849 heptosyltransferase III [EC:2.4.-.-] [KO:K02849] [EC:2.4.-.-]
waaI; LPS biosynthesis enzyme [KO:K03275] [EC:2.4.1.-]
waaJ; UDP-glucose:(galactosyl) LPS alpha-1,2-glucosyltransferase [KO:K03279] [EC:2.4.1.58]
waaL; LPS biosynthesis enzyme [KO:K02847] [EC:6.-.-.-]
Compound
C00043  
UDP-N-acetyl-alpha-D-glucosamine
C00229  
Acyl-carrier protein
C01112  
D-Arabinose 5-phosphate
C01187  
3-Deoxy-D-manno-octulosonate
C04121  
CMP-3-deoxy-D-manno-octulosonate
C04478  
3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  
UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  
Lipid X
C04919  
2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  
Lipid A disaccharide
C05223  
Dodecanoyl-[acyl-carrier protein]
C05382  
Sedoheptulose 7-phosphate
C05761  
Tetradecanoyl-[acp]
C06022  
UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  
3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  
Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  
Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  
Lauroyl-KDO2-lipid IV(A)
C06397  
ADP-D-glycero-beta-D-manno-heptose
C06398  
ADP-L-glycero-beta-D-manno-heptose
C07836  
D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  
D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  
D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  
4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  
D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  
D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  
D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  
GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
 
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