KEGG   PATHWAY: fal00253Help
Entry
fal00253                    Pathway                                

Name
Tetracycline biosynthesis - Frankia alni
Class
Metabolism; Metabolism of terpenoids and polyketides
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Pathway map
Tetracycline biosynthesis
fal00253

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BSID: 
GO: 
Organism
Frankia alni [GN:fal]
Gene
acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; K01962 acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2] K01963 acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2] [KO:K01962 K01963] [EC:6.4.1.2 6.4.1.2]
accA; acetyl carboxylase [KO:K01962 K01963] [EC:6.4.1.2 6.4.1.2]
accB; biotin carboxyl carrier protein [KO:K02160]
biotin carboxyl carrier protein; K02160 acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
accC; acetyl CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.3.4.14 6.4.1.2]
accC; biotin carboxylase [KO:K11263] [EC:6.3.4.14 6.4.1.3 6.4.1.2]
accC; acetyl-/propionyl-coenzyme A carboxylase subunit alpha [KO:K11263] [EC:6.3.4.14 6.4.1.3 6.4.1.2]
accC; acetyl CoA carboxylase, biotin carboxylase subunit [KO:K11263] [EC:6.3.4.14 6.4.1.3 6.4.1.2]
acetyl/propionyl CoA carboxylase subunit beta; K18472 acetyl/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3] [KO:K18472] [EC:6.4.1.3 6.4.1.2]
pccB; propionyl-CoA carboxylase subunit beta [KO:K18472] [EC:6.4.1.3 6.4.1.2]
halogenase; K14257 FADH2 O2-dependent halogenase [EC:1.14.14.-] [KO:K14257] [EC:1.14.14.-]
Compound
C00024  
Acetyl-CoA
C00083  
Malonyl-CoA
C02811  
Anhydrotetracycline
C03206  
5a,11a-Dehydrotetracycline
C06570  
Tetracycline
C06571  
Chlortetracycline
C06624  
Oxytetracycline
C06625  
Malonamoyl-CoA
C06626  
4-Ketoanhydrochlortetracycline
C06627  
4-Keto-anhydrotetracycline
C06628  
4-Hydroxy-6-methylpretetramide
C06629  
6-Methylpretetramide
C06654  
4-Amino-anhydrotetracycline
C12441  
Nonaketamide
C12442  
C-9 Reduced nonaketamide
C18293  
Nonaketamide monocyclic intermediate
C18294  
Nonaketamide tricyclic intermediate
C18295  
Pretetramid
C18296  
5a,11a-Dehydrooxytetracycline
C18297  
Anhydrochlortetracycline
C18298  
5a,11a-Dehydrochlortetracycline
C18299  
4-Aminoanhydrochlortetracycline
Reference
  Authors
Petkovic H, Cullum J, Hranueli D, Hunter IS, Peric-Concha N, Pigac J, Thamchaipenet A, Vujaklija D, Long PF
  Title
Genetics of Streptomyces rimosus, the oxytetracycline producer.
  Journal
Microbiol Mol Biol Rev 70:704-28 (2006)
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
Reference
  Authors
Paul M Dewick.
  Title
Medicinal Natural Products -A Biosynthetic Approach- (2nd ed)
  Journal
John Wiley and Sons, LTD:376-379 (2001)
Reference
PMID:1134373
  Authors
Miller PA, Hash JH
  Title
S-adenosylmethionine:dedimethylamino-4-aminoanhydrotetracycline N-methyltransferase.
  Journal
Methods Enzymol 43:603-6 (1975)
Reference
PMID:1134374
  Authors
Miller PA, Hash JH
  Title
ADP; tetracyclin 5a(11a)dehydrogenase.
  Journal
Methods Enzymol 43:606-7 (1975)
Reference
  Authors
Wang P, Zhang W, Zhan J, Tang Y
  Title
Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis.
  Journal
Chembiochem 10:1544-50 (2009)
Reference
  Authors
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J
  Title
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
  Journal
J Am Chem Soc 130:6068-9 (2008)
Reference
  Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
  Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
  Journal
J Biol Chem 274:32829-34 (1999)
Reference
  Authors
Peric-Concha N, Borovicka B, Long PF, Hranueli D, Waterman PG, Hunter IS
  Title
Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.
  Journal
J Biol Chem 280:37455-60 (2005)
Reference
  Authors
Zhang W, Watanabe K, Wang CC, Tang Y
  Title
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
  Journal
J Biol Chem 282:25717-25 (2007)
Reference
PMID:8163168
  Authors
Kim ES, Bibb MJ, Butler MJ, Hopwood DA, Sherman DH.
  Title
Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.
  Journal
Gene 141:141-2 (1994)
Reference
PMID:7612997
  Authors
Dairi T, Nakano T, Aisaka K, Katsumata R, Hasegawa M.
  Title
Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.
  Journal
Biosci Biotechnol Biochem 59:1099-106 (1995)
KO pathway
 

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