KEGG   PATHWAY: fca04723
Entry
fca04723                    Pathway                                
Name
Retrograde endocannabinoid signaling - Felis catus (domestic cat)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
fca04723  Retrograde endocannabinoid signaling
fca04723

Other DBs
GO: 0071926
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101096579  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
101098576  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
100216332  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
101097621  GRIA1; glutamate receptor 1 isoform X2 [KO:K05197]
101088234  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
101089925  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101087003  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101094104  GRM1; metabotropic glutamate receptor 1 isoform X2 [KO:K04603]
101091895  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101087993  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101090597  NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2 [KO:K13985] [EC:3.1.4.54]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082946  DAGLA; diacylglycerol lipase-alpha isoform X1 [KO:K13806] [EC:3.1.1.116]
101101020  DAGLB; diacylglycerol lipase-beta isoform X1 [KO:K13806] [EC:3.1.1.116]
100126581  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
101099621  ABHD6; monoacylglycerol lipase ABHD6 [KO:K13700] [EC:3.1.1.23]
101095511  FAAH; fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
101081996  vitamin D3 hydroxylase-associated protein-like [KO:K15528] [EC:3.5.1.99]
493926  CNR1; cannabinoid receptor 1 [KO:K04277]
101092837  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101100320  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101089679  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101101353  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
101086580  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101093317  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101084799  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101091855  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101081809  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101097491  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101091560  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101081928  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
111561761  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101088219  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101090817  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
111557526  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101088915  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101084346  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101089378  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101086526  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101088476  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101096184  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101088179  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
101080818  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
101091342  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
101091726  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
101094827  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101100749  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101091211  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101089928  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
807939  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807935  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807938  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807928  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807937  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807929  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807930  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101093395  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101080579  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101084817  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101085609  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101096376  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101081685  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
101099952  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101091711  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101092508  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101084209  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101091174  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X3 [KO:K03951]
101091412  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101092862  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101093631  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X4 [KO:K03954]
101099010  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101093917  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101081479  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
101100189  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101086911  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
101082389  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101093382  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X3 [KO:K03959]
101089135  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101090177  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101096614  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101091850  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101091655  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101085859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101083475  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101097623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101100747  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101088298  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101096914  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101089240  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
101094940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101101113  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101096448  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101094451  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
101091693  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101080736  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101096880  SLC32A1; vesicular inhibitory amino acid transporter isoform X1 [KO:K15015]
101088410  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
101098052  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
100294524  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
100286792  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175]
101093992  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175]
100286789  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
101090773  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175]
100286790  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X2 [KO:K05181]
101097640  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
101094237  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X2 [KO:K05181]
100286791  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
101099123  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
101094182  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X3 [KO:K05186]
101087589  GABRD; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
101095805  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
101099698  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
101095468  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X3 [KO:K05189]
101093186  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
101093609  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
101082769  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
fca00190  Oxidative phosphorylation
fca04020  Calcium signaling pathway
fca04721  Synaptic vesicle cycle
fca04724  Glutamatergic synapse
fca04727  GABAergic synapse
KO pathway
ko04723   

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Genome (1)   
   KEGG GENOME (1)   
Gene (148)   
   KEGG GENES (148)   
All databases (149)   

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