KEGG   PATHWAY: gga00240Help
Entry
gga00240                    Pathway                                
Name
Pyrimidine metabolism - Gallus gallus (chicken)
Class
Metabolism; Nucleotide metabolism
BRITE hierarchy
Pathway map
Pyrimidine metabolism
gga00240

All organismsOrtholog table
Module
Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:gga00240]
Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP [PATH:gga00240]
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:gga00240]
Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP [PATH:gga00240]
Other DBs
BSID: 
GO: 
Organism
Gallus gallus (chicken) [GN:gga]
Gene
428659  
CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [KO:K11540] [EC:3.5.2.3 2.1.3.2 6.3.5.5]
415876  
DHODH; dihydroorotate dehydrogenase [KO:K00254] [EC:1.3.5.2]
424256  
UMPS; uridine monophosphate synthetase [KO:K13421] [EC:4.1.1.23 2.4.2.10]
429100  
CMPK1; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic [KO:K13800] [EC:2.7.4.14 2.7.4.-]
421921  
CMPK2; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial [KO:K13809] [EC:2.7.4.14]
426534  
AK3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
426866  
NME6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) [KO:K00940] [EC:2.7.4.6]
395916  
NME2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
422094  
NME1; non-metastatic cells 1, protein (NM23A) expressed in [KO:K00940] [EC:2.7.4.6]
416399  
NME3; non-metastatic cells 3, protein expressed in [KO:K00940] [EC:2.7.4.6]
NME7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
426732  
NME5; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) [KO:K00940] [EC:2.7.4.6]
395915  
NME4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
421206  
PNPT1; polyribonucleotide nucleotidyltransferase 1 [KO:K00962] [EC:2.7.7.8]
374095  
ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
428447  
ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
423826  
ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
430103  
CANT1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
419531  
ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
423343  
ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
416708  
ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
424390  
ITPA; inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [KO:K01519] [EC:3.6.1.19]
418620  
CTPS2; CTP synthase II [KO:K01937] [EC:6.3.4.2]
419561  
CTPS; CTP synthase [KO:K01937] [EC:6.3.4.2]
422910  
POLR1A; polymerase (RNA) I polypeptide A, 194kDa [KO:K02999] [EC:2.7.7.6]
420603  
TWISTNB; TWIST neighbor [KO:K03004]
426805  
POLR1E; polymerase (RNA) I polypeptide E, 53kDa [KO:K03005]
422621  
POLR2B; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [KO:K03010] [EC:2.7.7.6]
415635  
POLR2C; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa [KO:K03011]
424754  
POLR2D; polymerase (RNA) II (DNA directed) polypeptide D [KO:K03012]
420103  
POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa [KO:K03013]
395486  
POLR2F; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014]
424954  
POLR2H; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016]
426289  
POLR2I; polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa [KO:K03017]
770704  
POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa [KO:K03007]
771626  
DNA-directed RNA polymerases I; K03009 DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
423727  
POLR3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa [KO:K03018] [EC:2.7.7.6]
418071  
POLR3B; polymerase (RNA) III (DNA directed) polypeptide B [KO:K03021] [EC:2.7.7.6]
416620  
POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD) [KO:K14721]
421452  
POLR1C; polymerase (RNA) I polypeptide C, 30kDa [KO:K03027]
768505  
POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa [KO:K03019]
428713  
POLR1D; polymerase (RNA) I polypeptide D, 16kDa [KO:K03020]
417990  
POLR3H; polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) [KO:K03022]
427105  
POLR3G; polymerase (RNA) III (DNA directed) polypeptide G (32kD) [KO:K03024]
416723  
POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa [KO:K03025]
418593  
POLA1; polymerase (DNA directed), alpha 1, catalytic subunit [KO:K02320] [EC:2.7.7.7]
DNA polymerase alpha subunit B-like; K02321 DNA polymerase alpha subunit B [KO:K02321]
DNA polymerase alpha subunit B-like; K02321 DNA polymerase alpha subunit B [KO:K02321]
426646  
PRIM1; primase, DNA, polypeptide 1 (49kDa) [KO:K02684] [EC:2.7.7.-]
421878  
PRIM2; primase, DNA, polypeptide 2 (58kDa) [KO:K02685] [EC:2.7.7.-]
DNA polymerase delta subunit 2-like; K02328 DNA polymerase delta subunit 2 [KO:K02328]
419053  
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
416997  
POLE; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
423567  
POLE2; polymerase (DNA directed), epsilon 2 (p59 subunit) [KO:K02325] [EC:2.7.7.7]
417275  
POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) [KO:K02326] [EC:2.7.7.7]
771901  
UCK1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
424406  
UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
419255  
ZNF512B; zinc finger protein 512B [KO:K00876] [EC:2.7.1.48]
419675  
NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
421833  
NT5E; 5'-nucleotidase, ecto (CD73) [KO:K01081] [EC:3.1.3.5]
421954  
NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
395080  
NT5C3; 5'-nucleotidase, cytosolic III [KO:K01081] [EC:3.1.3.5]
423871  
NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
416505  
NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
420034  
NT5C3L; 5'-nucleotidase, cytosolic III-like [KO:K01081] [EC:3.1.3.5]
424326  
UPP2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
420942  
UPP1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
422327  
UPRT; uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) [KO:K00761] [EC:2.4.2.9]
429083  
DPYD; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
420266  
DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
416949  
UPB1; ureidopropionase, beta [KO:K01431] [EC:3.5.1.6]
416782  
TXNRD2; thioredoxin reductase 2 [KO:K00384] [EC:1.8.1.9]
416031  
TXNRD3; thioredoxin reductase 3 [KO:K00384] [EC:1.8.1.9]
418082  
TXNRD1; thioredoxin reductase 1 [KO:K00384] [EC:1.8.1.9]
419081  
RRM1; ribonucleotide reductase M1 [KO:K10807] [EC:1.17.4.1]
420253  
RRM2B; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
421936  
RRM2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
769338  
DUT; deoxyuridine triphosphatase [KO:K01520] [EC:3.6.1.23]
421060  
TYMS; thymidylate synthetase [KO:K00560] [EC:2.1.1.45]
771849  
CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
769958  
purine nucleoside phosphorylase-like; K03783 purine-nucleoside phosphorylase [EC:2.4.2.1] [KO:K03783] [EC:2.4.2.1]
422648  
DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74]
770922  
deoxycytidine kinase-like; K00893 deoxycitidine kinase [EC:2.7.1.74] [KO:K00893] [EC:2.7.1.74]
422556  
DCTD; dCMP deaminase [KO:K01493] [EC:3.5.4.12]
395719  
TK1; thymidine kinase 1, soluble [KO:K00857] [EC:2.7.1.21]
427551  
TK2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
770258  
DTYMK; deoxythymidylate kinase (thymidylate kinase) [KO:K00943] [EC:2.7.4.9]
427399  
NUDT2; nudix (nucleoside diphosphate linked moiety X)-type motif 2 [KO:K01518] [EC:3.6.1.17]
418114  
uncharacterized LOC418114; K16330 pseudouridine-5'-phosphate glycosidase / pseudouridine kinase [EC:3.2.-.- 2.7.1.83] [KO:K16330] [EC:2.7.1.83 3.2.-.-]
Compound
C00015  
UDP
C00029  
UDP-glucose
C00039  
DNA
C00046  
RNA
C00055  
CMP
C00063  
CTP
C00064  
L-Glutamine
C00075  
UTP
C00086  
Urea
C00099  
beta-Alanine
C00105  
UMP
C00106  
Uracil
C00112  
CDP
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00169  
Carbamoyl phosphate
C00178  
Thymine
C00214  
Thymidine
C00222  
3-Oxopropanoate
C00239  
dCMP
C00295  
Orotate
C00299  
Uridine
C00337  
(S)-Dihydroorotate
C00342  
Thioredoxin
C00343  
Thioredoxin disulfide
C00363  
dTDP
C00364  
dTMP
C00365  
dUMP
C00380  
Cytosine
C00383  
Malonate
C00429  
5,6-Dihydrouracil
C00438  
N-Carbamoyl-L-aspartate
C00458  
dCTP
C00459  
dTTP
C00460  
dUTP
C00475  
Cytidine
C00526  
Deoxyuridine
C00672  
2-Deoxy-D-ribose 1-phosphate
C00705  
dCDP
C00813  
Barbiturate
C00881  
Deoxycytidine
C00906  
5,6-Dihydrothymine
C01013  
3-Hydroxypropanoate
C01103  
Orotidine 5'-phosphate
C01168  
Pseudouridine 5'-phosphate
C01346  
dUDP
C01368  
3'-UMP
C01563  
Carbamate
C02067  
Pseudouridine
C02170  
Methylmalonate
C02354  
2',3'-Cyclic CMP
C02355  
2',3'-Cyclic UMP
C02376  
5-Methylcytosine
C02642  
3-Ureidopropionate
C03997  
5-Hydroxymethyldeoxycytidylate
C05100  
3-Ureidoisobutyrate
C05145  
3-Aminoisobutyric acid
C05281  
5-Methylbarbiturate
C05822  
3'-CMP
C06198  
P1,P4-Bis(5'-uridyl) tetraphosphate
C11038  
2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate
C11039  
2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate
C15607  
3-Oxo-3-ureidopropanoate
C20231  
(Z)-3-Ureidoacrylate peracid
C20249  
(Z)-3-Peroxyaminoacrylate
C20253  
Aminoacrylate
C20254  
Ureidoacrylate
KO pathway
 
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