KEGG   PATHWAY: gga03440Help
Entry
gga03440                    Pathway                                

Name
Homologous recombination - Gallus gallus (chicken)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
gga03440

All organismsOrtholog table
Module
RPA complex [PATH:gga03440]
MRN complex [PATH:gga03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:gga03440]
Other DBs
BSID: 
GO: 
Organism
Gallus gallus (chicken) [GN:gga]
Gene
418122  
SSBP1; single stranded DNA binding protein 1 [KO:K03111]
416329  
RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
395555  
MRE11; MRE11 homolog, double strand break repair nuclease [KO:K10865]
374246  
NBN; nibrin [KO:K10867]
395401  
ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
373983  
BRCA1; breast cancer 1 [KO:K10605] [EC:2.3.2.27]
424010  
BARD1; BRCA1 associated RING domain 1 [KO:K10683]
421071  
RBBP8; RB binding protein 8, endonuclease [KO:K20773] [EC:3.1.-.-]
417642  
BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
420694  
TOPBP1; topoisomerase (DNA) II binding protein 1 [KO:K10728]
422608  
FAM175A; family with sequence similarity 175 member A [KO:K20774]
416145  
UIMC1; ubiquitin interaction motif containing 1 [KO:K20775]
776677  
BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776]
421417  
BRE; brain and reproductive organ-expressed (TNFRSF1A modulator) [KO:K12173]
422201  
BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864] [EC:3.4.19.-]
416572  
PALB2; partner and localizer of BRCA2 [KO:K10897]
374139  
BRCA2; BRCA2, DNA repair associated [KO:K08775]
772237  
C7orf76; chromosome 7 open reading frame 76 [KO:K10881]
418097  
SYCP3; synaptonemal complex protein 3 [KO:K19528]
417563  
RPA1; replication protein A1 [KO:K07466]
419566  
RPA2; replication protein A2 [KO:K10739]
420578  
RPA3; replication protein A3 [KO:K10740]
396086  
RAD51; RAD51 recombinase [KO:K04482]
418152  
RAD52; RAD52 homolog, DNA repair protein [KO:K10873]
769071  
RAD51B; RAD51 paralog B [KO:K10869]
417626  
RAD51C; RAD51 paralog C [KO:K10870]
417528  
RAD51D; RAD51 paralog D [KO:K10871]
420438  
XRCC2; X-ray repair cross complementing 2 [KO:K10879]
423485  
XRCC3; X-ray repair cross complementing 3 [KO:K10880]
424611  
RAD54L; RAD54-like (S. cerevisiae) [KO:K10875] [EC:3.6.4.-]
395449  
RAD54B; RAD54 homolog B (S. cerevisiae) [KO:K10877] [EC:3.6.4.-]
POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
DNA polymerase delta subunit 2-like [KO:K02328]
419053  
POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
415577  
BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:3.6.4.12]
416517  
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
416771  
TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
422104  
EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
 

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