KEGG   PATHWAY: gga03440Help
Entry
gga03440                    Pathway                                

Name
Homologous recombination - Gallus gallus (chicken)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
gga03440  Homologous recombination
gga03440

Ortholog table
Module
gga_M00288  RPA complex [PATH:gga03440]
gga_M00291  MRN complex [PATH:gga03440]
gga_M00295  BRCA1-associated genome surveillance complex (BASC) [PATH:gga03440]
Other DBs
BSID: 83954
GO: 0000724
Organism
Gallus gallus (chicken) [GN:gga]
Gene
418122  SSBP1; single stranded DNA binding protein 1 [KO:K03111]
416329  RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
395555  MRE11; MRE11 homolog, double strand break repair nuclease [KO:K10865]
374246  NBN; nibrin [KO:K10867]
395401  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
373983  BRCA1; breast cancer 1 [KO:K10605] [EC:2.3.2.27]
424010  BARD1; BRCA1 associated RING domain 1 [KO:K10683]
421071  RBBP8; RB binding protein 8, endonuclease [KO:K20773] [EC:3.1.-.-]
417642  BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
420694  TOPBP1; topoisomerase (DNA) II binding protein 1 [KO:K10728]
422608  FAM175A; family with sequence similarity 175 member A [KO:K20774]
416145  UIMC1; ubiquitin interaction motif containing 1 [KO:K20775]
776677  BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776]
421417  BRE; brain and reproductive organ-expressed (TNFRSF1A modulator) [KO:K12173]
422201  BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864] [EC:3.4.19.-]
416572  PALB2; partner and localizer of BRCA2 [KO:K10897]
374139  BRCA2; BRCA2, DNA repair associated [KO:K08775]
772237  C7orf76; chromosome 7 open reading frame 76 [KO:K10881]
418097  SYCP3; synaptonemal complex protein 3 [KO:K19528]
417563  RPA1; replication protein A1 [KO:K07466]
419566  RPA2; replication protein A2 [KO:K10739]
420578  RPA3; replication protein A3 [KO:K10740]
396086  RAD51; RAD51 recombinase [KO:K04482]
418152  RAD52; RAD52 homolog, DNA repair protein [KO:K10873]
769071  RAD51B; RAD51 paralog B [KO:K10869]
417626  RAD51C; RAD51 paralog C [KO:K10870]
417528  RAD51D; RAD51 paralog D [KO:K10871]
420438  XRCC2; X-ray repair cross complementing 2 [KO:K10879]
423485  XRCC3; X-ray repair cross complementing 3 [KO:K10880]
424611  RAD54L; RAD54-like (S. cerevisiae) [KO:K10875] [EC:3.6.4.-]
395449  RAD54B; RAD54 homolog B (S. cerevisiae) [KO:K10877] [EC:3.6.4.-]
100859398  POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
107057377  DNA polymerase delta subunit 2-like [KO:K02328]
419053  POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
415577  BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:3.6.4.12]
416517  TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
416771  TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
422104  EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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