KEGG   PATHWAY: gga03440Help
Entry
gga03440                    Pathway                                

Name
Homologous recombination - Gallus gallus (chicken)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
gga03440

All organismsOrtholog table
Module
RPA complex [PATH:gga03440]
MRN complex [PATH:gga03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:gga03440]
Other DBs
BSID: 
GO: 
Organism
Gallus gallus (chicken) [GN:gga]
Gene
418122  
SSBP1; single-stranded DNA binding protein 1, mitochondrial [KO:K03111]
416329  
RAD50; RAD50 homolog (S. cerevisiae) [KO:K10866] [EC:3.6.-.-]
395555  
MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [KO:K10865]
374246  
NBN; nibrin [KO:K10867]
417563  
RPA1; replication protein A1, 70kDa [KO:K07466]
419566  
RPA2; replication protein A2, 32kDa [KO:K10739]
420578  
RPA3; replication protein A3, 14kDa [KO:K10740]
396086  
RAD51; RAD51 recombinase [KO:K04482]
418152  
RAD52; RAD52 homolog (S. cerevisiae) [KO:K10873]
374139  
BRCA2; breast cancer 2, early onset [KO:K08775]
772237  
SHFM1; split hand/foot malformation (ectrodactyly) type 1 [KO:K10881]
769071  
RAD51B; RAD51 paralog B [KO:K10869]
417626  
RAD51C; RAD51 homolog C (S. cerevisiae) [KO:K10870]
417528  
RAD51D; RAD51 paralog D [KO:K10871]
420438  
XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2 [KO:K10879]
423485  
XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3 [KO:K10880]
424611  
RAD54L; RAD54-like (S. cerevisiae) [KO:K10875] [EC:3.6.4.-]
395449  
RAD54B; RAD54 homolog B (S. cerevisiae) [KO:K10877] [EC:3.6.4.-]
POLD2; polymerase (DNA directed), delta 2, accessory subunit [KO:K02328]
419053  
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
415577  
BLM; Bloom syndrome, RecQ helicase-like [KO:K10901] [EC:3.6.4.12]
416517  
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
416771  
TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
422104  
EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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