KEGG   PATHWAY: gga03460Help
Entry
gga03460                    Pathway                                
Name
Fanconi anemia pathway - Gallus gallus (chicken)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Fanconi anemia pathway
gga03460

All organismsOrtholog table
Module
DNA polymerase zeta  complex [PATH:gga03460]
BRCA1-associated genome surveillance complex (BASC) [PATH:gga03460]
FA core complex [PATH:gga03460]
Bloom's syndrome complex [PATH:gga03460]
Other DBs
BSID: 
GO: 
Organism
Gallus gallus (chicken) [GN:gga]
Gene
415949  
ATRIP; ATR interacting protein [KO:K10905]
424777  
ATR; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
Fanconi anemia group M protein homolog; K10896 fanconi anemia group M protein [KO:K10896]
415770  
C11H19orf40; chromosome 11 open reading frame, human C19orf40 [KO:K10898]
771417  
APITD1; apoptosis-inducing, TAF9-like domain 1 [KO:K11511]
416757  
TELO2; TEL2, telomere maintenance 2, homolog (S. cerevisiae) [KO:K11137]
395128  
HES1; hairy and enhancer of split 1, (Drosophila) [KO:K06054]
C18H17orf70; FancA associated protein of 100 kDa [KO:K10993]
415854  
FANCA; Fanconi anemia, complementation group A [KO:K10888]
418628  
FANCB; Fanconi anemia, complementation group B [KO:K10889]
427468  
FANCC; Fanconi anemia, complementation group C [KO:K10890]
378893  
FANCG; Fanconi anemia, complementation group G [KO:K10894]
421202  
FANCL; Fanconi anemia, complementation group L [KO:K10606] [EC:6.3.2.19]
420427  
WDR48; WD repeat domain 48 [KO:K15361]
424685  
USP1; ubiquitin specific peptidase 1 [KO:K11832] [EC:3.1.2.15]
421149  
UBE2T; ubiquitin-conjugating enzyme E2T (putative) [KO:K13960] [EC:6.3.2.19]
415491  
FANCI; Fanconi anemia, complementation group I [KO:K10895]
415935  
FANCD2; Fanconi anemia, complementation group D2 [KO:K10891]
374139  
BRCA2; breast cancer 2, early onset [KO:K08775]
416572  
PALB2; partner and localizer of BRCA2 [KO:K10897]
417626  
RAD51C; RAD51 homolog C (S. cerevisiae) [KO:K10870]
396086  
RAD51; RAD51 homolog (S. cerevisiae) [KO:K04482]
373983  
BRCA1; breast cancer 1, early onset [KO:K10605]
417642  
BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
415383  
FAN1; FANCD2/FANCI-associated nuclease 1 [KO:K15363]
420729  
MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [KO:K08734]
418703  
REV1; REV1 homolog (S. cerevisiae) [KO:K03515] [EC:2.7.7.-]
428622  
REV3L; REV3-like, catalytic subunit of DNA polymerase zeta (yeast) [KO:K02350] [EC:2.7.7.7]
395102  
POLH; polymerase (DNA directed), eta [KO:K03509] [EC:2.7.7.7]
374003  
POLK; polymerase (DNA directed) kappa [KO:K03511] [EC:2.7.7.7]
431669  
RMI1; RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) [KO:K10990]
416628  
RMI2; RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae) [KO:K15365]
416517  
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
416771  
TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
415577  
BLM; Bloom syndrome, RecQ helicase-like [KO:K10901] [EC:3.6.4.12]
417563  
RPA1; replication protein A1, 70kDa [KO:K07466]
419566  
RPA2; replication protein A2, 32kDa [KO:K10739]
420578  
RPA3; replication protein A3, 14kDa [KO:K10740]
422104  
EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe) [KO:K10882] [EC:3.1.22.-]
416400  
EME2; essential meiotic endonuclease 1 homolog 2 (S. pombe) [KO:K10883]
416420  
ERCC4; excision repair cross-complementing rodent repair deficiency, complementation group 4 [KO:K10848] [EC:3.1.-.-]
424727  
structure-specific endonuclease subunit SLX1-like; K15078 structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] [KO:K15078] [EC:3.6.1.-]
416665  
SLX4; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) [KO:K10484]
structure-specific endonuclease subunit SLX4-like; K10484 structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) [KO:K10484]
Reference
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
Reference
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
Reference
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
Reference
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
Reference
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
Reference
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
KO pathway
 
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