KEGG PATHWAY: gga04120

PATHWAY: gga04120

Entry

gga04120 Pathway

Name

Ubiquitin mediated proteolysis - Gallus gallus (chicken)

Description

Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

gga04120

Ubiquitin mediated proteolysis

Module

gga_M00379	SCF-MET30 complex [PATH:gga04120]
gga_M00380	SCF-BTRC complex [PATH:gga04120]
gga_M00381	SCF-SKP2 complex [PATH:gga04120]
gga_M00382	SCF-FBS complex [PATH:gga04120]
gga_M00383	ECV complex [PATH:gga04120]
gga_M00384	Cul3-SPOP complex [PATH:gga04120]
gga_M00385	Cul4-DDB1-DDB2 complex [PATH:gga04120]
gga_M00386	Cul4-DDB1-CSA complex [PATH:gga04120]
gga_M00387	SCF-FBW7 complex [PATH:gga04120]
gga_M00388	ECS complex [PATH:gga04120]
gga_M00389	APC/C complex [PATH:gga04120]
gga_M00407	SCF-CDC4 complex [PATH:gga04120]
gga_M00411	SCF-GRR1 complex [PATH:gga04120]

Other DBs

BSID:

83962

GO:

0016567

Organism

Gallus gallus (chicken) [GN:gga]

Gene

415784	UBA2; ubiquitin-like modifier activating enzyme 2 [KO:K10685] [EC:6.3.2.19]
426073	UBA3; ubiquitin-like modifier activating enzyme 3 [KO:K10686] [EC:6.3.2.19]
395178	UBA7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.3.2.19]
422655	UBA6; ubiquitin-like modifier activating enzyme 6 [KO:K10699] [EC:6.3.2.19]
395672	UBE2A; ubiquitin-conjugating enzyme E2A [KO:K10573] [EC:6.3.2.19]
100857678	ubiquitin-conjugating enzyme E2 B-like; K10574 ubiquitin-conjugating enzyme E2 B [EC:6.3.2.19] [KO:K10574] [EC:6.3.2.19]
100859413	ubiquitin-conjugating enzyme E2 C-like; K06688 ubiquitin-conjugating enzyme E2 C [EC:6.3.2.19] [KO:K06688] [EC:6.3.2.19]
424122	UBE2E3; ubiquitin-conjugating enzyme E2E 3 [KO:K06689] [EC:6.3.2.19]
422713	UBE2D3; ubiquitin-conjugating enzyme E2D 3 [KO:K06689] [EC:6.3.2.19]
420653	UBE2E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) [KO:K06689] [EC:6.3.2.19]
776043	UBE2E2; ubiquitin-conjugating enzyme E2E 2 [KO:K06689] [EC:6.3.2.19]
416137	UBE2D2; ubiquitin-conjugating enzyme E2D 2 [KO:K06689] [EC:6.3.2.19]
423641	UBE2D1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [KO:K06689] [EC:6.3.2.19]
424015	UBE2F; ubiquitin-conjugating enzyme E2F (putative) [KO:K10687] [EC:6.3.2.19]
770961	UBE2G1; ubiquitin-conjugating enzyme E2G 1 [KO:K10575] [EC:6.3.2.19]
424837	UBE2G2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:6.3.2.19]
416678	UBE2H; ubiquitin-conjugating enzyme E2H [KO:K10576] [EC:6.3.2.19]
374123	UBE2I; ubiquitin-conjugating enzyme E2I [KO:K10577] [EC:6.3.2.19]
395528	UBE2J1; ubiquitin-conjugating enzyme E2, J1, U [KO:K10578] [EC:6.3.2.19]
419421	UBE2J2; ubiquitin-conjugating enzyme E2, J2 [KO:K04554] [EC:6.3.2.19]
416769	UBE2L3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:6.3.2.19]
100858641	NEDD8-conjugating enzyme Ubc12-like; K10579 ubiquitin-conjugating enzyme E2 M [EC:6.3.2.19] [KO:K10579] [EC:6.3.2.19]
417898	UBE2N; ubiquitin-conjugating enzyme E2N [KO:K10580] [EC:6.3.2.19]
417359	UBE2O; ubiquitin-conjugating enzyme E2O [KO:K10581] [EC:6.3.2.19]
415356	UBE2Q2; ubiquitin-conjugating enzyme E2Q family member 2 [KO:K10582] [EC:6.3.2.19]
100858564	ubiquitin-conjugating enzyme E2 Q1-like; K10582 ubiquitin-conjugating enzyme E2 Q [EC:6.3.2.19] [KO:K10582] [EC:6.3.2.19]
427021	UBE2R2; ubiquitin-conjugating enzyme E2R 2 [KO:K02207] [EC:6.3.2.19]
425483	CDC34; cell division cycle 34 homolog (S. cerevisiae) [KO:K02207] [EC:6.3.2.19]
427134	ubiquitin-conjugating enzyme E2 R2-like; K02207 ubiquitin-conjugating enzyme E2 R [EC:6.3.2.19] [KO:K02207] [EC:6.3.2.19]
420185	UBE2W; ubiquitin-conjugating enzyme E2W (putative) [KO:K10688] [EC:6.3.2.19]
419991	UBE2Z; ubiquitin-conjugating enzyme E2Z [KO:K10585] [EC:6.3.2.19]
428787	UBE2K; ubiquitin-conjugating enzyme E2K [KO:K04649] [EC:6.3.2.19]
421463	BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:6.3.2.19]
418686	UBE3A; ubiquitin protein ligase E3A [KO:K10587] [EC:6.3.2.19]
374194	UBE3B; ubiquitin protein ligase E3B [KO:K10588] [EC:6.3.2.19]
776286	ubiquitin-protein ligase E3B-like; K10588 ubiquitin-protein ligase E3 B [EC:6.3.2.19] [KO:K10588] [EC:6.3.2.19]
420447	UBE3C; ubiquitin protein ligase E3C [KO:K10589] [EC:6.3.2.19]
427809	SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
416487	SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
419145	ITCH; itchy E3 ubiquitin protein ligase homolog (mouse) [KO:K05632] [EC:6.3.2.19]
420212	WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
415868	WWP2; WW domain containing E3 ubiquitin protein ligase 2 [KO:K05630] [EC:6.3.2.19]
424785	TRIP12; thyroid hormone receptor interactor 12 [KO:K10590] [EC:6.3.2.19]
415406	NEDD4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:6.3.2.19]
374119	NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:6.3.2.19]
420252	UBR5; ubiquitin protein ligase E3 component n-recognin 5 [KO:K10593] [EC:6.3.2.19]
415367	HERC1; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 [KO:K10594] [EC:6.3.2.19]
418682	HERC2; hect domain and RLD 2 [KO:K10595] [EC:6.3.2.19]
422514	HERC3; hect domain and RLD 3 [KO:K10614] [EC:6.3.2.19]
423683	HERC4; hect domain and RLD 4 [KO:K10615] [EC:6.3.2.19]
419758	UBE4A; ubiquitination factor E4A [KO:K10596] [EC:6.3.2.19]
419448	UBE4B; ubiquitination factor E4B [KO:K10597] [EC:6.3.2.19]
426918	STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase [KO:K09561] [EC:6.3.2.19]
416775	PPIL2; peptidylprolyl isomerase (cyclophilin)-like 2 [KO:K10598] [EC:5.2.1.8]
430767	PRPF19; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) [KO:K10599] [EC:6.3.2.19]
422940	UBOX5; U-box domain containing 5 [KO:K10600]
395609	MDM2; Mdm2 p53 binding protein homolog (mouse) [KO:K06643] [EC:6.3.2.19]
374038	CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence [KO:K04707] [EC:6.3.2.19]
418406	CBLB; Cas-Br-M (murine) ecotropic retroviral transforming sequence b [KO:K04707] [EC:6.3.2.19]
421577	PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin) [KO:K04556] [EC:6.3.2.19]
374076	SIAH1; seven in absentia homolog 1 (Drosophila) [KO:K04506] [EC:6.3.2.19]
415302	PML; promyelocytic leukemia [KO:K10054]
415304	PML; promyelocytic leukemia [KO:K10054]
423163	TRAF6; TNF receptor-associated factor 6 [KO:K03175]
427144	MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
429072	RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:6.3.2.19]
771726	RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:6.3.2.19]
374012	BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
395280	XIAP; X-linked inhibitor of apoptosis [KO:K04725]
419239	BIRC7; baculoviral IAP repeat containing 7 [KO:K16061]
427514	PIAS1; protein inhibitor of activated STAT, 1 [KO:K04706] [EC:6.3.2.-]
416383	PIAS2; protein inhibitor of activated STAT, 2 [KO:K16063] [EC:6.3.2.-]
420095	PIAS4; protein inhibitor of activated STAT, 4 [KO:K16065] [EC:6.3.2.-]
100859884	E3 ubiquitin-protein ligase synoviolin-like; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
428477	NHLRC1; NHL repeat containing 1 [KO:K10602] [EC:6.3.2.19]
429666	AIRE; autoimmune regulator [KO:K10603]
416660	MGRN1; mahogunin, ring finger 1 [KO:K10604] [EC:6.3.2.19]
373983	BRCA1; breast cancer 1, early onset [KO:K10605]
421202	FANCL; Fanconi anemia, complementation group L [KO:K10606] [EC:6.3.2.19]
373920	MID1; midline 1 (Opitz/BBB syndrome) [KO:K08285] [EC:6.3.2.19]
417628	TRIM37; tripartite motif containing 37 [KO:K10608]
418001	RBX1; ring-box 1, E3 ubiquitin protein ligase [KO:K03868]
420783	CUL1; cullin 1 [KO:K03347]
416319	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
416181	FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
423854	BTRC; beta-transducin repeat containing [KO:K03362]
427437	SKP2; S-phase kinase-associated protein 2 (p45) [KO:K03875]
422481	FBXW7; F-box and WD repeat domain containing 7 [KO:K10260]
419074	F-box/WD repeat-containing protein 7-like; K10260 F-box and WD-40 domain protein 7 [KO:K10260]
419495	FBXO2; F-box protein 2 [KO:K10099]
431586	FBXO4; F-box protein 4 [KO:K10291]
420467	CUL2; cullin 2 [KO:K03870]
420187	TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) [KO:K03872]
430688	transcription elongation factor B polypeptide 2-like; K03873 transcription elongation factor B, polypeptide 2 [KO:K03873]
416117	VHL; von Hippel-Lindau tumor suppressor [KO:K03871]
424804	CUL3; cullin 3 [KO:K03869]
422226	KLHL13; kelch-like 9 (Drosophila) [KO:K10447]
419536	RHOBTB2; Rho-related BTB domain containing 2 [KO:K07868]
423664	RHOBTB1; Rho-related BTB domain containing 1 [KO:K07868]
422364	CUL4B; cullin 4B [KO:K10609]
418744	CUL4A; cullin 4A [KO:K10609]
374050	DDB1; damage-specific DNA binding protein 1, 127kDa [KO:K10610]
423185	DDB2; damage-specific DNA binding protein 2, 48kDa [KO:K10140]
427153	ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8 [KO:K10570]
415497	DET1; de-etiolated homolog 1 (Arabidopsis) [KO:K10571]
424781	RNF7; ring finger protein 7 [KO:K10611]
418969	CUL5; cullin 5 [KO:K10612]
416630	SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
395299	SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
417024	FBXW8; F-box and WD repeat domain containing 8 [KO:K10264]
417258	ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
424563	CDC20; cell division cycle 20 homolog (S. cerevisiae) [KO:K03363]
373959	FZR1; fizzy/cell division cycle 20 related 1 (Drosophila) [KO:K03364]
421228	ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
419960	CDC27; cell division cycle 27 homolog (S. cerevisiae) [KO:K03350]
422805	ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
416842	ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
418735	CDC16; cell division cycle 16 homolog (S. cerevisiae) [KO:K03353]
416838	ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
771857	CDC23; cell division cycle 23 homolog (S. cerevisiae) [KO:K03355]
422461	ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
417269	CDC26; cell division cycle 26 homolog (S. cerevisiae) [KO:K03359]
769605	ANAPC13; anaphase promoting complex subunit 13 [KO:K12456]

Reference

PMID:16922370 (Japanese)

Authors

Kamura T.

Title

[Cullin-based E3 family] Japanese

Journal

Tanpakushitsu Kakusan Koso 51:1167-72 (2006)

Reference

PMID:16922408 (Japanese)

Authors

Matsuda N.

Title

[Overview: hereditary disorders caused by dysfunction of ubiquitylation]

Journal

Tanpakushitsu Kakusan Koso 51:1402-7 (2006)

Reference

PMID:16922367 (Japanese)

Authors

Tokunaga F.

Title

[E2 ubiquitin-conjugating enzymes: structures and functions]

Journal

Tanpakushitsu Kakusan Koso 51:1150-6 (2006)

Reference

PMID:16816840

Authors

Nalepa G, Rolfe M, Harper JW.

Title

Drug discovery in the ubiquitin-proteasome system.

Journal

Nat Rev Drug Discov 5:596-613 (2006)

Reference

PMID:16405856

Authors

Hsu YJ, Goodman SR.

Title

Spectrin and ubiquitination: a review.

Journal

Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)

Reference

PMID:12944364

Authors

Hatakeyama S, Nakayama KI.

Title

Ubiquitylation as a quality control system for intracellular proteins.

Journal

J Biochem 134:1-8 (2003)

Reference

PMID:17588513

Authors

Lee J, Zhou P.

Title

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Journal

Mol Cell 26:775-80 (2007)

KO pathway

ko04120

All links

Pathway (10)   
   KEGG MODULE (9)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (123)   
   KEGG GENES (123)   
All databases (134)   

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