KEGG PATHWAY: gga04141

PATHWAY: gga04141

Entry

gga04141 Pathway

Name

Protein processing in endoplasmic reticulum - Gallus gallus (chicken)

Description

The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

gga04141

Protein processing in endoplasmic reticulum

Module

gga_M00382	SCF-FBS complex [PATH:gga04141]
gga_M00400	p97-Ufd1-Npl4 complex [PATH:gga04141]
gga_M00401	Sec61 complex [PATH:gga04141]
gga_M00402	Translocon-associated protein (TRAP) complex [PATH:gga04141]
gga_M00403	HRD1/SEL1 ERAD complex [PATH:gga04141]
gga_M00404	COPII complex [PATH:gga04141]

Other DBs

BSID:

167335

GO:

0030433 0034976

Organism

Gallus gallus (chicken) [GN:gga]

Gene

416023	SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
426369	SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
776639	SEC61G; Sec61 gamma subunit [KO:K07342]
424993	SEC62; SEC62 homolog (S. cerevisiae) [KO:K12275]
421774	SEC63; SEC63 homolog (S. cerevisiae) [KO:K09540]
416017	RPN1; ribophorin I [KO:K12666]
419177	RPN2; ribophorin II [KO:K12667]
395343	DAD1; defender against cell death 1 [KO:K12668]
422738	TUSC3; tumor suppressor candidate 3 [KO:K12669]
425542	DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase [KO:K12670]
428444	STT3B; STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) [KO:K07151] [EC:2.4.99.18]
100857165	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
418073	CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
396414	RRBP1; ribosome binding protein 1 homolog 180kDa (dog) [KO:K14000]
416185	SIL1; SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) [KO:K14001]
428251	HYOU1; hypoxia up-regulated 1 [KO:K09486]
396487	HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [KO:K09490]
424868	DNAJB11; DnaJ (Hsp40) homolog, subfamily B, member 11 [KO:K09517]
420508	DNAJC1; DnaJ (Hsp40) homolog, subfamily C, member 1 [KO:K09521]
418787	DNAJC3; DnaJ (Hsp40) homolog, subfamily C, member 3 [KO:K09523]
424115	DNAJC10; DnaJ (Hsp40) homolog, subfamily C, member 10 [KO:K09530]
374163	HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 [KO:K09487]
416288	CANX; calnexin [KO:K08054]
373899	PDIA3; protein disulfide isomerase family A, member 3 [KO:K08056] [EC:5.3.4.1]
420146	CALR3; calreticulin 3 [KO:K08057]
417296	MAN1B1; mannosidase, alpha, class 1B, member 1 [KO:K01230] [EC:3.2.1.113]
421726	MAN1A1; mannosidase, alpha, class 1A, member 1 [KO:K01230] [EC:3.2.1.113]
419588	MAN1C1; mannosidase, alpha, class 1C, member 1 [KO:K01230] [EC:3.2.1.113]
418265	MAN1A2; mannosidase, alpha, class 1A, member 2 [KO:K01230] [EC:3.2.1.113]
100859676	vesicular integral-membrane protein VIP36-like; K10082 lectin, mannose-binding 2 [KO:K10082]
426849	LMAN1; lectin, mannose-binding, 1 [KO:K10080]
100858986	prolactin regulatory element-binding protein-like; K14003 prolactin regulatory element-binding protein [KO:K14003]
423711	SAR1A; SAR1 homolog A (S. cerevisiae) [KO:K07953] [EC:3.6.5.-]
416314	SAR1B; SAR1 homolog B (S. cerevisiae) [KO:K07953] [EC:3.6.5.-]
416119	SEC13; SEC13 homolog (S. cerevisiae) [KO:K14004]
422597	SEC31A; SEC31 homolog A (S. cerevisiae) [KO:K14005]
423764	SEC31B; SEC31 homolog B (S. cerevisiae) [KO:K14005]
416724	SEC23B; Sec23 homolog B (S. cerevisiae) [KO:K14006]
423335	SEC23A; Sec23 homolog A (S. cerevisiae) [KO:K14006]
422523	SEC24B; SEC24 family, member B (S. cerevisiae) [KO:K14007]
416313	SEC24A; SEC24 family, member A (S. cerevisiae) [KO:K14007]
423742	SEC24C; SEC24 family, member C (S. cerevisiae) [KO:K14007]
422683	SEC24D; SEC24 family, member D (S. cerevisiae) [KO:K14007]
424757	UGGT1; UDP-glucose glycoprotein glucosyltransferase 1 [KO:K11718] [EC:2.4.1.-]
418785	UGGT2; UDP-glucose glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
416110	EDEM1; ER degradation enhancer, mannosidase alpha-like 1 [KO:K10084]
770034	EDEM2; ER degradation enhancer, mannosidase alpha-like 2 [KO:K10085]
424450	EDEM3; ER degradation enhancer, mannosidase alpha-like 3 [KO:K10086]
396376	GSBP9; glycosylation site-binding protein [KO:K09580] [EC:5.3.4.1]
374091	P4HB; prolyl 4-hydroxylase, beta polypeptide [KO:K09580] [EC:5.3.4.1]
420785	PDIA4; protein disulfide isomerase family A, member 4 [KO:K09582] [EC:5.3.4.1]
421940	PDIA6; protein disulfide isomerase family A, member 6 [KO:K09584] [EC:5.3.4.1]
416882	ERP29; endoplasmic reticulum protein 29 [KO:K09586]
420867	TXNDC5; thioredoxin domain containing 5 (endoplasmic reticulum) [KO:K13984]
423585	ERO1L; ERO1-like (S. cerevisiae) [KO:K10950] [EC:1.8.4.-]
421509	ERO1LB; ERO1-like beta (S. cerevisiae) [KO:K10976] [EC:1.8.4.-]
420871	SSR1; signal sequence receptor, alpha [KO:K13249]
425656	SSR2; signal sequence receptor, beta (translocon-associated protein beta) [KO:K13250]
425027	SSR3; signal sequence receptor, gamma (translocon-associated protein gamma) [KO:K13251]
100857815	B-cell receptor-associated protein 31-like; K14009 B-cell receptor-associated protein 31 [KO:K14009]
378918	TRAM1; translocation associated membrane protein 1 [KO:K14010]
420350	DERL1; Der1-like domain family, member 1 [KO:K11519]
417498	DERL2; Der1-like domain family, member 2 [KO:K13989]
416934	DERL3; Der1-like domain family, member 3 [KO:K13989]
428329	UBXN6; UBX domain protein 6 [KO:K14011]
419268	NSFL1C; NSFL1 (p97) cofactor (p47) [KO:K14012]
771022	small VCP/p97-interacting protein-like; K14014 small VCP/p97-interacting protein [KO:K14014]
427410	VCP; valosin containing protein [KO:K13525]
417456	NPLOC4; nuclear protein localization 4 homolog (S. cerevisiae) [KO:K14015]
374186	UFD1L; ubiquitin fusion degradation 1 like (yeast) [KO:K14016]
395853	HSPA8; heat shock 70kDa protein 8 [KO:K03283]
423504	HSPA2; heat shock 70kDa protein 2 [KO:K03283]
427376	DNAJA1; DnaJ (Hsp40) homolog, subfamily A, member 1 [KO:K09502]
415744	DNAJA2; DnaJ (Hsp40) homolog, subfamily A, member 2 [KO:K09503]
427022	dnaJ homolog subfamily B member 2-like; K09508 DnaJ homolog subfamily B member 2 [KO:K09508]
423707	DNAJB12; DnaJ (Hsp40) homolog, subfamily B, member 12 [KO:K09518]
419256	DNAJC5; DnaJ (Hsp40) homolog, subfamily C, member 5 [KO:K09525]
428358	DNAJC5B; DnaJ (Hsp40) homolog, subfamily C, member 5 beta [KO:K09525]
396188	HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 [KO:K04079]
423463	HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO:K04079]
418917	HSPH1; heat shock 105kDa/110kDa protein 1 [KO:K09485]
422496	HSPA4L; heat shock 70kDa protein 4-like [KO:K09485]
420967	BAG1; BCL2-associated athanogene [KO:K09555]
421880	BAG2; BCL2-associated athanogene 2 [KO:K09556]
100858988	hsp70-binding protein 1-like; K09562 hsp70-interacting protein [KO:K09562]
418546	CRYAA; crystallin, alpha A [KO:K09541]
396089	CRYAB; crystallin, alpha B [KO:K09542]
428266	YOD1; YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) [KO:K13719] [EC:3.1.2.-]
427365	PLAA; phospholipase A2-activating protein [KO:K14018]
431623	RAD23B; RAD23 homolog B (S. cerevisiae) [KO:K10839]
427454	UBQLN1; ubiquilin 1 [KO:K04523]
426353	UBQLN4; ubiquilin 4 [KO:K04523]
420655	NGLY1; N-glycanase 1 [KO:K01456] [EC:3.5.1.52]
378424	ATXN3; ataxin 3 [KO:K11863] [EC:3.4.22.-]
419448	UBE4B; ubiquitination factor E4B [KO:K10597] [EC:6.3.2.19]
395360	EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
395147	EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
422930	EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
423285	EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
423279	EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
396014	NFE2L2; nuclear factor (erythroid-derived 2)-like 2 [KO:K05638]
395693	ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
396282	BCL2; B-cell CLL/lymphoma 2 [KO:K02161]
424365	ATF6; activating transcription factor 6 [KO:K09054]
422857	WFS1; Wolfram syndrome 1 (wolframin) [KO:K14020]
415704	MBTPS1; membrane-bound transcription factor peptidase, site 1 [KO:K08653] [EC:3.4.21.112]
427996	MBTPS2; membrane-bound transcription factor peptidase, site 2 [KO:K07765] [EC:3.4.24.85]
416918	XBP1; X-box binding protein 1 [KO:K09027]
771230	ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:3.1.26.- 2.7.11.1]
417287	TRAF2; TNF receptor-associated factor 2 [KO:K03173]
421688	MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
423778	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
395983	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
422592	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
419912	BAK1; BCL2-antagonist/killer 1 [KO:K14021]
396240	CAPN1; calpain 1, (mu/I) large subunit [KO:K01367] [EC:3.4.22.52]
693249	CAPN1; calpain 1, (mu/I) large subunit [KO:K01367] [EC:3.4.22.52]
395963	CAPN2; calpain 2, (m/II) large subunit [KO:K03853] [EC:3.4.22.53]
420927	MARCH6; membrane-associated ring finger (C3HC4) 6 [KO:K10661] [EC:6.3.2.19]
395528	UBE2J1; ubiquitin-conjugating enzyme E2, J1, U [KO:K10578] [EC:6.3.2.19]
419421	UBE2J2; ubiquitin-conjugating enzyme E2, J2 [KO:K04554] [EC:6.3.2.19]
770961	UBE2G1; ubiquitin-conjugating enzyme E2G 1 [KO:K10575] [EC:6.3.2.19]
424837	UBE2G2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:6.3.2.19]
100859884	E3 ubiquitin-protein ligase synoviolin-like; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
416965	RNF185; ring finger protein 185 [KO:K10666] [EC:6.3.2.19]
415522	VIMP; VCP-interacting membrane protein [KO:K14025]
423391	SEL1L; sel-1 suppressor of lin-12-like (C. elegans) [KO:K14026]
415644	HERPUD1; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [KO:K14027]
415697	AMFR; autocrine motility factor receptor [KO:K10636] [EC:6.3.2.19]
426918	STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase [KO:K09561] [EC:6.3.2.19]
424122	UBE2E3; ubiquitin-conjugating enzyme E2E 3 [KO:K06689] [EC:6.3.2.19]
422713	UBE2D3; ubiquitin-conjugating enzyme E2D 3 [KO:K06689] [EC:6.3.2.19]
420653	UBE2E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) [KO:K06689] [EC:6.3.2.19]
776043	UBE2E2; ubiquitin-conjugating enzyme E2E 2 [KO:K06689] [EC:6.3.2.19]
416137	UBE2D2; ubiquitin-conjugating enzyme E2D 2 [KO:K06689] [EC:6.3.2.19]
423641	UBE2D1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [KO:K06689] [EC:6.3.2.19]
421577	PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin) [KO:K04556] [EC:6.3.2.19]
418001	RBX1; ring-box 1, E3 ubiquitin protein ligase [KO:K03868]
420783	CUL1; cullin 1 [KO:K03347]
416319	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
419495	FBXO2; F-box protein 2 [KO:K10099]
419494	FBXO6; F-box protein 6 [KO:K10100]

Compound

C00076	Calcium cation
G00009
G00010
G00011
G00012
G10694

Reference

PMID:19491040

Authors

Naidoo N

Title

ER and aging-Protein folding and the ER stress response.

Journal

Ageing Res Rev 8:150-9 (2009)

Reference

PMID:18023214

Authors

Malhotra JD, Kaufman RJ

Title

The endoplasmic reticulum and the unfolded protein response.

Journal

Semin Cell Dev Biol 18:716-31 (2007)

Reference

PMID:20347046

Authors

Maattanen P, Gehring K, Bergeron JJ, Thomas DY

Title

Protein quality control in the ER: the recognition of misfolded proteins.

Journal

Semin Cell Dev Biol 21:500-11 (2010)

Reference

PMID:20219571

Authors

Stolz A, Wolf DH

Title

Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.

Journal

Biochim Biophys Acta 1803:694-705 (2010)

Reference

PMID:20112977

Authors

Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY

Title

Organization of the Sec61 translocon, studied by high resolution native electrophoresis.

Journal

J Proteome Res 9:1763-71 (2010)

KO pathway

ko04141

All links

Pathway (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (142)   
   KEGG GENES (142)   
All databases (147)   

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