KEGG   PATHWAY: gga04810Help
Entry
gga04810                    Pathway                                

Name
Regulation of actin cytoskeleton - Gallus gallus (chicken)
Class
Cellular Processes; Cell motility
BRITE hierarchy
Pathway map
Regulation of actin cytoskeleton
gga04810

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BSID: 
GO: 
Organism
Gallus gallus (chicken) [GN:gga]
Gene
395306  
F2; coagulation factor II (thrombin) [KO:K01313] [EC:3.4.21.5]
427212  
F2R; coagulation factor II (thrombin) receptor [KO:K03914]
396145  
INS; insulin [KO:K04526]
408035  
EGF; epidermal growth factor [KO:K04357]
422330  
FGF16; fibroblast growth factor 16 [KO:K04358]
395394  
FGF19; fibroblast growth factor 19 [KO:K04358]
396413  
FGF2; fibroblast growth factor 2 (basic) [KO:K04358]
396094  
FGF1; fibroblast growth factor 1 (acidic) [KO:K04358]
428779  
FGF20; fibroblast growth factor 20 [KO:K04358]
395704  
FGF12; fibroblast growth factor 12 [KO:K04358]
768907  
FGF6; fibroblast growth factor 6 [KO:K04358]
428104  
FGF23; fibroblast growth factor 23 [KO:K04358]
378917  
FGF9; fibroblast growth factor 9 (glia-activating factor) [KO:K04358]
770457  
FGF5; fibroblast growth factor 5 [KO:K04358]
415439  
FGF7; fibroblast growth factor 7 [KO:K04358]
396267  
FGF3; fibroblast growth factor 3 [KO:K04358]
428857  
FGF4; fibroblast growth factor 4 [KO:K04358]
414831  
FGF13; fibroblast growth factor 13 [KO:K04358]
395453  
FGF18; fibroblast growth factor 18 [KO:K04358]
395554  
FGF14; fibroblast growth factor 14 [KO:K04358]
396313  
FGF8; fibroblast growth factor 8 (androgen-induced) [KO:K04358]
395432  
FGF10; fibroblast growth factor 10 [KO:K04358]
fibroblast growth factor 22-like; K04358 fibroblast growth factor [KO:K04358]
374196  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
374128  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K04359]
395469  
PDGFC; platelet derived growth factor C [KO:K05450]
418978  
PDGFD; platelet derived growth factor D [KO:K05450]
396494  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
396516  
FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
396259  
FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
396515  
FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
395603  
FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
395509  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
770488  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
396133  
FN1; fibronectin 1 [KO:K05717]
395951  
ITGA1; integrin, alpha 1 [KO:K06480]
integrin alpha-2-like; K06481 integrin alpha 2 [KO:K06481]
373946  
ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) [KO:K06482]
424121  
ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [KO:K06483]
396226  
ITGA6; integrin, alpha 6 [KO:K06485]
396225  
ITGA8; integrin, alpha 8 [KO:K06584]
420757  
ITGA9; integrin, alpha 9 [KO:K06585]
415560  
ITGA11; integrin, alpha 11 [KO:K06587]
396420  
ITGAV; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) [KO:K06487]
374058  
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
396181  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
374209  
ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [KO:K06493]
417374  
ITGB4; integrin, beta 4 [KO:K06525]
395142  
ITGB5; integrin, beta 5 [KO:K06588]
424191  
ITGB6; integrin, beta 6 [KO:K06589]
395470  
ITGB8; integrin, beta 8 [KO:K06591]
772372  
BDKRB1; bradykinin receptor B1 [KO:K03915]
428906  
BDKRB2; bradykinin receptor B2 [KO:K03916]
418126  
CHRM2; cholinergic receptor, muscarinic 2 [KO:K04130]
396364  
CHRM3; cholinergic receptor, muscarinic 3 [KO:K04131]
423195  
CHRM4; cholinergic receptor, muscarinic 4 [KO:K04132]
428881  
CHRM5; cholinergic receptor, muscarinic 5 [KO:K04133]
769924  
GNA12; guanine nucleotide binding protein (G protein) alpha 12 [KO:K04346]
417434  
GNA13; guanine nucleotide binding protein (G protein), alpha 13 [KO:K04639]
772239  
GNG12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
415989  
FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
396416  
PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
415691  
BCAR1; breast cancer anti-estrogen resistance 1 [KO:K05726]
417553  
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
416939  
CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
423960  
DOCK1; dedicator of cytokinesis 1 [KO:K13708]
396442  
SRC; v-src sarcoma viral oncogene [KO:K05704] [EC:2.7.10.2]
423572  
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
431192  
son of sevenless homolog 1-like; K03099 son of sevenless [KO:K03099]
396229  
HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
418207  
KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
419885  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
423062  
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
395149  
MRAS; muscle RAS oncogene homolog [KO:K07831]
422247  
ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [KO:K05729]
424971  
PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
419444  
PIK3CD; phosphoinositide-3-kinase, catalytic, delta polypeptide [KO:K00922] [EC:2.7.1.153]
417706  
PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
424826  
PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
429096  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
417319  
PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K02649]
771142  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
427171  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
373939  
VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
373938  
VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
418491  
TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
396239  
BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
396245  
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
428537  
MOS; v-mos Moloney murine sarcoma viral oncogene homolog [KO:K04367] [EC:2.7.11.1]
415549  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
396349  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
373953  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
419752  
ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12 [KO:K07532]
425730  
ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
395442  
RHOA; ras homolog gene family, member A [KO:K04513]
395871  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
418044  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
395870  
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
395917  
CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
419083  
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
424860  
PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
422342  
PAK3; p21 protein (Cdc42/Rac)-activated kinase 3 [KO:K05733] [EC:2.7.11.1]
770462  
PAK4; p21 protein (Cdc42/Rac)-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
428837  
PAK6; p21 protein (Cdc42/Rac)-activated kinase 6 [KO:K05735] [EC:2.7.11.1]
416734  
PAK7; p21 protein (Cdc42/Rac)-activated kinase 7 [KO:K05736] [EC:2.7.11.1]
418761  
ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7 [KO:K13710]
417584  
GIT1; G protein-coupled receptor kinase interactor 1 [KO:K05737]
373970  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
415748  
MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
396445  
MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
396356  
MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
428278  
myosin light chain kinase; K00907 myosin-light-chain kinase [EC:2.7.11.18] [KO:K00907] [EC:2.7.11.18]
420893  
MYLK4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
396019  
PPP1CB; protein phosphatase 1, catalytic subunit, beta isozyme [KO:K06269] [EC:3.1.3.16]
416872  
PPP1CC; protein phosphatase 1, catalytic subunit, gamma isozyme [KO:K06269] [EC:3.1.3.16]
396020  
PPP1R12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A [KO:K06270]
395478  
PPP1R12B; protein phosphatase 1, regulatory (inhibitor) subunit 12B [KO:K12329]
416874  
MYL2; myosin, light chain 2, regulatory, cardiac, slow [KO:K10351]
396215  
MYL9; myosin, light chain 9, regulatory [KO:K12755]
417506  
MYL10; myosin, light chain 10, regulatory [KO:K12756]
396284  
MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric [KO:K12757]
770011  
myosin regulatory light chain 2; K12757 myosin regulatory light chain 12 [KO:K12757]
776775  
MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
374040  
DIAPH1; diaphanous homolog 1 (Drosophila) [KO:K05741]
419580  
SLC9A1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 [KO:K05742]
427243  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
420072  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
429983  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
phosphatidylinositol-4-phosphate 5-kinase type-1 alpha-like; K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68] [KO:K00889] [EC:2.7.1.68]
420504  
PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
419999  
PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
424114  
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
373922  
LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
396010  
LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
418824  
DIAPH3; diaphanous homolog 3 (Drosophila) [KO:K05745]
422077  
BAIAP2; BAI1-associated protein 2 [KO:K05627]
374180  
ENAH; enabled homolog (Drosophila) [KO:K05746]
417750  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
426359  
WASF2; WAS protein family, member 2 [KO:K05748]
416246  
CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
418677  
CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
424000  
NCKAP1; NCK-associated protein 1 [KO:K05750]
425499  
NCKAP1L; NCK-associated protein 1-like [KO:K05750]
424108  
ABI2; abl-interactor 2 [KO:K05751]
421761  
WASF1; WAS protein family, member 1 [KO:K05753]
429075  
ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
416051  
ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
416837  
ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
416490  
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
770269  
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
429041  
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
396526  
ACTB; actin, beta [KO:K05692]
428177  
ACTRT1; actin-related protein T1 [KO:K05692]
415296  
ACTG1; actin, gamma 1 [KO:K05692]
776816  
actin; K05692 actin beta/gamma 1 [KO:K05692]
428564  
PFN3; profilin 3 [KO:K05759]
769795  
PFN4; profilin family, member 4 [KO:K05759]
771904  
PFN2; profilin 2 [KO:K05759]
395832  
PXN; paxillin [KO:K05760]
395701  
EZR; ezrin [KO:K08007]
395511  
RDX; radixin [KO:K05762]
408047  
TMSB4X; thymosin beta 4, X-linked [KO:K05764]
423320  
CFL2; cofilin 2 (muscle) [KO:K05765]
417586  
SSH2; slingshot homolog 2 (Drosophila) [KO:K05766]
396422  
VCL; vinculin [KO:K05700]
415591  
IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
395774  
GSN; gelsolin [KO:K05768]
420588  
SCIN; scinderin [KO:K05768]
373918  
ACTN1; actinin, alpha 1 [KO:K05699]
396024  
ACTN4; actinin, alpha 4 [KO:K05699]
396263  
ACTN2; actinin, alpha 2 [KO:K05699]
415607  
APC; adenomatous polyposis coli [KO:K02085]
429363  
APC2; adenomatosis polyposis coli 2 [KO:K02085]
424761  
ARHGEF4; Rho guanine nucleotide exchange factor (GEF) 4 [KO:K05769]
Compound
C00306  
Bradykinin
C00338  
Lipopolysaccharide
C01996  
Acetylcholine
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
KO pathway
 

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