KEGG   PATHWAY: gmx00030Help
gmx00030                    Pathway                                

Pentose phosphate pathway - Glycine max (soybean)
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
gmx00030  Pentose phosphate pathway

Ortholog table
gmx_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:gmx00030]
gmx_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:gmx00030]
gmx_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:gmx00030]
gmx_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:gmx00030]
Other DBs
BSID: 552702
GO: 0006098
Glycine max (soybean) [GN:gmx]
100818441  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:]
100791285  glucose-6-phosphate isomerase 1, chloroplastic-like [KO:K01810] [EC:]
100798134  glucose-6-phosphate isomerase, cytosolic-like [KO:K01810] [EC:]
100807719  glucose-6-phosphate isomerase, cytosolic-like [KO:K01810] [EC:]
100809452  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:]
100791496  glucose-6-phosphate isomerase 1, chloroplastic-like [KO:K01810] [EC:]
100814915  glucose-6-phosphate isomerase, cytosolic 2-like [KO:K01810] [EC:]
100796541  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:]
100817852  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:]
100780018  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:]
100793462  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:]
100815891  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic-like [KO:K00036] [EC:]
100793694  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:]
100806107  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:]
100811075  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:]
100777353  glucose-6-phosphate 1-dehydrogenase 1, chloroplastic-like [KO:K00036] [EC:]
100801945  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:]
100794078  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:]
100792737  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:]
100809411  probable 6-phosphogluconolactonase 2-like [KO:K01057] [EC:]
100803687  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:]
100804571  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:]
100806593  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:]
100796103  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:]
100803740  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:]
547455  GND; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
100799034  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:]
100818789  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:]
106794441  uncharacterized LOC106794441 [KO:K00033] [EC:]
100786514  ribulose-phosphate 3-epimerase, chloroplastic [KO:K01783] [EC:]
100500085  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:]
100527490  uncharacterized LOC100527490 [KO:K01783] [EC:]
100817791  ribulose-phosphate 3-epimerase, chloroplastic-like [KO:K01783] [EC:]
100805786  transketolase, chloroplastic [KO:K00615] [EC:]
100818028  transketolase, chloroplastic [KO:K00615] [EC:]
100781676  transketolase, chloroplastic [KO:K00615] [EC:]
100789900  transaldolase-like [KO:K00616] [EC:]
100807267  transaldolase [KO:K00616] [EC:]
100800377  transaldolase-like [KO:K00616] [EC:]
100813545  transaldolase-like [KO:K00616] [EC:]
100811673  transaldolase [KO:K00616] [EC:]
100816075  transaldolase-like [KO:K00616] [EC:]
100806367  transaldolase-like [KO:K00616] [EC:]
100797142  transaldolase-like [KO:K00616] [EC:]
100792885  transaldolase-like [KO:K00616] [EC:]
100792138  transaldolase-like [KO:K00616] [EC:]
106795612  transaldolase-like [KO:K00616] [EC:]
102659644  uncharacterized LOC102659644 [KO:K00616] [EC:]
106795613  transaldolase-like [KO:K00616] [EC:]
100781866  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:]
100792666  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:]
100790894  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:]
100783936  probable ribose-5-phosphate isomerase 4, chloroplastic [KO:K01807] [EC:]
100795150  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:]
100787958  ribokinase-like [KO:K00852] [EC:]
100801418  ribokinase-like [KO:K00852] [EC:]
102666284  ribokinase-like [KO:K00852] [EC:]
100802789  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:]
100780166  phosphoglucomutase, cytoplasmic-like [KO:K01835] [EC:]
100802730  phosphoglucomutase, chloroplastic [KO:K01835] [EC:]
100778321  phosphoglucomutase, chloroplastic [KO:K01835] [EC:]
100801499  phosphoglucomutase, cytoplasmic-like [KO:K01835] [EC:]
106798415  phosphoglucomutase, cytoplasmic-like [KO:K01835] [EC:]
100816430  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:]
100807743  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:]
100789585  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:]
100794730  ribose-phosphate pyrophosphokinase 1, chloroplastic [KO:K00948] [EC:]
100789100  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:]
100780041  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00131] [EC:]
100789108  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00131] [EC:]
100820082  probable gluconokinase [KO:K00851] [EC:]
100775407  thermosensitive gluconokinase-like [KO:K00851] [EC:]
100818383  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:]
100778363  fructose-bisphosphate aldolase, cytoplasmic isozyme-like [KO:K01623] [EC:]
100786504  probable fructose-bisphosphate aldolase 3, chloroplastic-like [KO:K01623] [EC:]
100527532  fructose-bisphosphate aldolase, cytoplasmic isozyme [KO:K01623] [EC:]
100798677  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:]
100792394  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:]
100815070  fructose-bisphosphate aldolase, cytoplasmic isozyme-like [KO:K01623] [EC:]
100818915  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:]
100795446  fructose-bisphosphate aldolase, cytoplasmic isozyme-like [KO:K01623] [EC:]
100775844  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:]
100802732  probable fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:]
547751  FBA; fructose-bisphosphate aldolase [KO:K01623] [EC:]
100783089  fructose-bisphosphate aldolase, cytoplasmic isozyme-like [KO:K01623] [EC:]
100815943  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:]
100793620  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:]
100787135  fructose-1,6-bisphosphatase, chloroplastic-like [KO:K03841] [EC:]
100812684  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:]
100799873  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:]
100807451  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:]
100797157  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:]
547809  FBP; fructose-1,6-bisphosphatase [KO:K03841] [EC:]
100815616  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:]
100807957  ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:]
100803139  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:]
100820495  ATP-dependent 6-phosphofructokinase 4, chloroplastic-like [KO:K00850] [EC:]
100818755  ATP-dependent 6-phosphofructokinase 6-like [KO:K00850] [EC:]
100793883  ATP-dependent 6-phosphofructokinase 5, chloroplastic-like [KO:K00850] [EC:]
100794539  ATP-dependent 6-phosphofructokinase 5, chloroplastic-like [KO:K00850] [EC:]
100795344  ATP-dependent 6-phosphofructokinase 7-like [KO:K00850] [EC:]
100798766  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:]
100780164  ATP-dependent 6-phosphofructokinase 5, chloroplastic-like [KO:K00850] [EC:]
100793844  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:]
100815278  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:]
100776597  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:]
100796769  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:]
100782166  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:]
100796614  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:]
100800863  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:]
100819847  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha-like [KO:K00895] [EC:]
100782857  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:]
100797925  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:]
100804429  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:]
102659565  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:]
100816216  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 1-like [KO:K00895] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway

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