KEGG   PATHWAY: har03440Help
Entry
har03440                    Pathway                                

Name
Homologous recombination - Herminiimonas arsenicoxydans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
har03440  Homologous recombination
har03440

Ortholog table
Module
har_M00260  DNA polymerase III complex, bacteria [PATH:har03440]
Other DBs
BSID: 48535
GO: 0000724
Organism
Herminiimonas arsenicoxydans [GN:har]
Gene
HEAR2227  recJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
HEAR1977  Putative single-stranded DNA binding protein [KO:K03111]
HEAR3096  ssb; Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) [KO:K03111]
HEAR2061  recO; DNA repair protein recO (Recombination protein O) [KO:K03584]
HEAR1047  recR; Recombination protein RecR [KO:K06187]
HEAR2628  recA; Protein RecA (Recombinase A) [KO:K03553]
HEAR0269  polA; DNA polymerase I (POL I) [KO:K02335] [EC:2.7.7.7]
HEAR0136  Putative 5'-3' exonuclease [KO:K02335] [EC:2.7.7.7]
HEAR0257  ruvA; Holliday junction DNA helicase ruvA [KO:K03550] [EC:3.6.4.12]
HEAR0258  ruvB; Holliday junction DNA helicase ruvB [KO:K03551] [EC:3.6.4.12]
HEAR0256  ruvC; Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC) (Holliday juction resolvase ruvC) [KO:K01159] [EC:3.1.22.4]
HEAR0301  recG; ATP-dependent DNA helicase recG [KO:K03655] [EC:3.6.4.12]
HEAR0456  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
HEAR0003  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
HEAR1045  dnaX; DNA polymerase III subunit tau [Contains: DNA polymerase III subunit gamma] [KO:K02343] [EC:2.7.7.7]
HEAR2663  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
HEAR1397  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
HEAR0580  putative DNA-polymerase/ribonuclease/exonuclease [KO:K02342] [EC:2.7.7.7]
HEAR2318  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
HEAR0742  putative DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
HEAR3385  priA; Primosomal protein N' [KO:K04066] [EC:3.6.4.-]
HEAR2161  priB; Primosomal replication protein N [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

DBGET integrated database retrieval system