KEGG   PATHWAY: hgl04726
Entry
hgl04726                    Pathway                                
Name
Serotonergic synapse - Heterocephalus glaber (naked mole-rat)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
hgl04726  Serotonergic synapse
hgl04726

Other DBs
GO: 0007210
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101714361  Tph2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
101710219  Tph1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
101697555  Ddc; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
101725597  Slc18a2; solute carrier family 18 member A2 [KO:K08155]
101703356  Slc18a1; solute carrier family 18 member A1 [KO:K08155]
101717129  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
101714832  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101722090  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
101726232  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
101708395  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
101726296  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
101699201  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
101715420  Gnaq; G protein subunit alpha q [KO:K04634]
101725860  Plcb1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
101696454  Plcb4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
101697744  Plcb3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
101708380  Plcb2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
101706047  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101716022  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101706978  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101716044  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101722702  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101698346  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
101706099  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101702687  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101705849  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
101706202  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
101703792  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
101717491  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
101713091  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
101704061  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
101708592  cytochrome P450 2C55 [KO:K07413] [EC:1.14.14.1]
101710990  cytochrome P450 2C5 [KO:K07413] [EC:1.14.14.1]
101722985  cytochrome P450 2D6-like [KO:K07414] [EC:1.14.14.1]
101724171  cytochrome P450 2D16 [KO:K07414] [EC:1.14.14.1]
101723802  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
101724763  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
101719021  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101719368  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101706848  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
101700210  Alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101702123  Alox12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]
101708945  Alox12b; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
101698545  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101698854  Ptgs1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
101704771  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
101717686  Htr3e; 5-hydroxytryptamine receptor 3E [KO:K04819]
101714088  Htr3a; 5-hydroxytryptamine receptor 3A [KO:K04819]
101726074  Htr3b; 5-hydroxytryptamine receptor 3B [KO:K04819]
101707865  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101708777  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101719078  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101716905  Gnas; GNAS complex locus [KO:K04632]
101705689  guanine nucleotide-binding protein G(s) subunit alpha isoforms short [KO:K04632]
101702436  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
101707235  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101721558  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101725711  Kcnn2; potassium calcium-activated channel subfamily N member 2 [KO:K04943]
101712898  Kcnd2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
101721168  Gabrb2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
101717539  Gabrb1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
101711687  Gabrb3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
101711127  Rapgef3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
101724743  App; amyloid beta precursor protein [KO:K04520]
101708206  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
101697435  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
101705725  Htr1e; 5-hydroxytryptamine receptor 1E [KO:K04153]
101718872  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
101718952  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
101713011  5-hydroxytryptamine receptor 5B [KO:K04161]
101723065  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
101698645  Gnai2; G protein subunit alpha i2 [KO:K04630]
101702965  Gnai1; G protein subunit alpha i1 [KO:K04630]
101703043  Gnai3; G protein subunit alpha i3 [KO:K04630]
101723580  Gnao1; G protein subunit alpha o1 [KO:K04534]
101703108  Gnb1; G protein subunit beta 1 [KO:K04536]
101711479  Gnb2; G protein subunit beta 2 [KO:K04537]
101718903  Gnb3; G protein subunit beta 3 [KO:K07825]
101714761  Gnb4; G protein subunit beta 4 [KO:K04538]
101698655  Gnb5; G protein subunit beta 5 [KO:K04539]
101719408  Gng2; G protein subunit gamma 2 [KO:K07826]
101726057  Gng3; G protein subunit gamma 3 [KO:K04540]
101696772  Gng4; G protein subunit gamma 4 [KO:K04541]
101718403  Gng5; G protein subunit gamma 5 [KO:K04542]
101711281  Gng7; G protein subunit gamma 7 [KO:K04543]
106007571  Gng8; G protein subunit gamma 8 [KO:K04544]
106007577  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101721082  Gng11; G protein subunit gamma 11 [KO:K04546]
101725110  Gng12; G protein subunit gamma 12 [KO:K04347]
101709292  Gng13; G protein subunit gamma 13 [KO:K04547]
101720513  Gngt1; G protein subunit gamma transducin 1 [KO:K04548]
101721190  Gngt2; G protein subunit gamma transducin 2 [KO:K04549]
101712867  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
101696390  caspase-3 [KO:K02187] [EC:3.4.22.56]
101723884  caspase-3-like [KO:K02187] [EC:3.4.22.56]
101701425  Dusp1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101716053  Hras; HRas proto-oncogene, GTPase [KO:K02833]
101718997  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
101719269  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
101723157  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
101702762  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101721841  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101715628  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101725815  Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
101697609  Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
101718832  Kcnj3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
101719327  Kcnj6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
101722613  Kcnj9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
101720856  Kcnj5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
101696653  Trpc1; transient receptor potential cation channel subfamily C member 1 [KO:K04964]
101705584  Slc6a4; solute carrier family 6 member 4 [KO:K05037]
101725537  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
101724899  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
hgl00380  Tryptophan metabolism
hgl00590  Arachidonic acid metabolism
hgl04020  Calcium signaling pathway
hgl04721  Synaptic vesicle cycle
hgl04976  Bile secretion
KO pathway
ko04726   

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