KEGG   PATHWAY: hor03440
Entry
hor03440                    Pathway                                
Name
Homologous recombination - Halothermothrix orenii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
hor03440  Homologous recombination
hor03440

Other DBs
GO: 0000724
Organism
Halothermothrix orenii [GN:hor]
Gene
Hore_12210  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Hore_23350  single-strand binding protein [KO:K03111]
Hore_00040  DNA replication and repair protein RecF [KO:K03629]
Hore_12480  DNA repair protein RecO [KO:K03584]
Hore_20770  recombination protein RecR [KO:K06187]
Hore_11890  recA protein [KO:K03553]
Hore_04860  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Hore_12320  Holliday junction DNA helicase RuvA [KO:K03550]
Hore_12310  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Hore_12330  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Hore_10120  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Hore_03140  DNA polymerase III catalytic subunit, DnaE type [KO:K02337] [EC:2.7.7.7]
Hore_07800  DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
Hore_00020  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Hore_20790  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Hore_12890  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Hore_20360  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Hore_09880  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG GENES (18)   
All databases (19)   

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