KEGG   PATHWAY: hsa00040Help
Entry
hsa00040                    Pathway                                

Name
Pentose and glucuronate interconversions - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Pentose and glucuronate interconversions
hsa00040

All organismsOrtholog table
Module
Glucuronate pathway (uronate pathway) [PATH:hsa00040]
Disease
H01065  
Pentosuria
H01193  
Familial tumoral calcinosis (FTC)
Organism
Homo sapiens (human) [GN:hsa]
Gene
2990  
GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
9365  
KL; klotho [KO:K14756] [EC:3.2.1.31]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
7358  
UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
7360  
UGP2; UDP-glucose pyrophosphorylase 2 [KO:K00963] [EC:2.7.7.9]
10327  
AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase) [KO:K00002] [EC:1.1.1.2]
51084  
CRYL1; crystallin lambda 1 [KO:K13247] [EC:1.1.1.45]
6120  
RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]
729020  
RPEL1; ribulose-5-phosphate-3-epimerase-like 1 [KO:K01783] [EC:5.1.3.1]
9942  
XYLB; xylulokinase homolog (H. influenzae) [KO:K00854] [EC:2.7.1.17]
231  
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
57016  
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
51181  
DCXR; dicarbonyl/L-xylulose reductase [KO:K03331] [EC:1.1.1.10]
6652  
SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]
27294  
DHDH; dihydrodiol dehydrogenase [KO:K00078] [EC:1.1.1.179 1.3.1.20]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
Compound
C00022  
Pyruvate
C00026  
2-Oxoglutarate
C00029  
UDP-glucose
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00116  
Glycerol
C00167  
UDP-glucuronate
C00181  
D-Xylose
C00191  
D-Glucuronate
C00199  
D-Ribulose 5-phosphate
C00204  
2-Dehydro-3-deoxy-D-gluconate
C00231  
D-Xylulose 5-phosphate
C00259  
L-Arabinose
C00266  
Glycolaldehyde
C00309  
D-Ribulose
C00310  
D-Xylulose
C00312  
L-Xylulose
C00333  
D-Galacturonate
C00379  
Xylitol
C00433  
2,5-Dioxopentanoate
C00470  
Pectate
C00474  
Ribitol
C00476  
D-Lyxose
C00502  
D-Xylonate
C00508  
L-Ribulose
C00514  
D-Mannonate
C00532  
L-Arabitol
C00558  
D-Tagaturonate
C00618  
3-Dehydro-L-gulonate
C00714  
Pectin
C00789  
CDP-ribitol
C00800  
L-Gulonate
C00817  
D-Altronate
C00905  
D-Fructuronate
C01068  
D-Ribitol 5-phosphate
C01101  
L-Ribulose 5-phosphate
C01508  
L-Lyxose
C01904  
D-Arabitol
C02266  
D-Xylonolactone
C02273  
Digalacturonate
C02426  
L-Glyceraldehyde
C03033  
beta-D-Glucuronoside
C03291  
L-Xylulose 5-phosphate
C03826  
2-Dehydro-3-deoxy-D-xylonate
C04053  
5-Dehydro-4-deoxy-D-glucuronate
C04349  
(4S)-4,6-Dihydroxy-2,5-dioxohexanoate
C04575  
(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  
D-Glucuronate 1-phosphate
C05411  
L-Xylonate
C05412  
L-Lyxonate
C06118  
4-(4-Deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate
C06441  
L-Xylulose 1-phosphate
C14899  
3-Dehydro-L-gulonate 6-phosphate
C15930  
L-Galactonate
C20680  
2-Dehydro-3-deoxy-L-galactonate
Reference
  Authors
Yew WS, Gerlt JA.
  Title
Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.
  Journal
J Bacteriol 184:302-6 (2002)
Reference
  Authors
Yew WS, Akana J, Wise EL, Rayment I, Gerlt JA
  Title
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
  Journal
Biochemistry 44:1807-15 (2005)
Reference
  Authors
Yasueda H, Kawahara Y, Sugimoto S.
  Title
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  Journal
J Bacteriol 181:7154-60 (1999)
Reference
  Authors
Ibanez E, Gimenez R, Pedraza T, Baldoma L, Aguilar J, Badia J
  Title
Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.
  Journal
J Bacteriol 182:4625-7 (2000)
Reference
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
KO pathway
 

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