KEGG   PATHWAY: hsa00053Help
Entry
hsa00053                    Pathway                                

Name
Ascorbate and aldarate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ascorbate and aldarate metabolism
hsa00053

All organismsOrtholog table
Drug
D00123  
Cyanamide (JP17)
D00131  
Disulfiram (JP17/USP/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
7358  
UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
55586  
MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
9104  
RGN; regucalcin [KO:K01053] [EC:3.1.1.17]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
Compound
C00022  
Pyruvate
C00026  
2-Oxoglutarate
C00029  
UDP-glucose
C00072  
Ascorbate
C00096  
GDP-mannose
C00137  
myo-Inositol
C00167  
UDP-glucuronate
C00191  
D-Glucuronate
C00231  
D-Xylulose 5-phosphate
C00259  
L-Arabinose
C00333  
D-Galacturonate
C00433  
2,5-Dioxopentanoate
C00545  
L-Arabinonate
C00618  
3-Dehydro-L-gulonate
C00679  
5-Dehydro-4-deoxy-D-glucarate
C00684  
2-Dehydro-3-deoxy-L-arabinonate
C00800  
L-Gulonate
C00818  
D-Glucarate
C00879  
D-Galactarate
C01040  
L-Gulono-1,4-lactone
C01041  
Monodehydroascorbate
C01101  
L-Ribulose 5-phosphate
C01114  
L-Arabinono-1,4-lactone
C01115  
L-Galactono-1,4-lactone
C01146  
2-Hydroxy-3-oxopropanoate
C01620  
Threonate
C01825  
L-Galactose
C02280  
GDP-L-galactose
C02670  
D-Glucuronolactone
C03064  
3-Dehydro-L-threonate
C03289  
L-xylo-Hexulonolactone
C03291  
L-Xylulose 5-phosphate
C03921  
2-Dehydro-3-deoxy-D-glucarate
C04575  
(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  
D-Glucuronate 1-phosphate
C05411  
L-Xylonate
C05412  
L-Lyxonate
C05422  
Dehydroascorbate
C14899  
3-Dehydro-L-gulonate 6-phosphate
C15923  
L-Gulose
C15924  
L-Gulose 1-phosphate
C15925  
GDP-L-gulose
C15926  
beta-L-Galactose 1-phosphate
C15930  
L-Galactonate
C16186  
L-Ascorbate 6-phosphate
C20889  
D-Galactaro-1,5-lactone
C20896  
D-Galactaro-1,4-lactone
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
KO pathway
 

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