KEGG   PATHWAY: hsa00100Help
Entry
hsa00100                    Pathway                                

Name
Steroid biosynthesis - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Steroid biosynthesis
hsa00100

All organismsOrtholog table
Module
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol [PATH:hsa00100]
Cholecalciferol biosynthesis [PATH:hsa00100]
Disease
H00148  
Lysosomal acid lipase deficiency
H00161  
Smith-Lemli-Opitz syndrome
H00496  
Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
H00617  
Desmosterolosis
H01143  
Vitamin D-dependent rickets
H01194  
X-linked chondrodysplasia punctata
H01281  
Lathosterolosis
H01371  
Hypercalcemia infantile
Drug
D03012  
Avasimibe (USAN/INN)
D03734  
Eldacimibe (USAN/INN)
D03735  
Lecimibide (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2222  
FDFT1; farnesyl-diphosphate farnesyltransferase 1 [KO:K00801] [EC:2.5.1.21]
6713  
SQLE; squalene epoxidase [KO:K00511] [EC:1.14.14.17]
4047  
LSS; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) [KO:K01852] [EC:5.4.99.7]
1595  
CYP51A1; cytochrome P450 family 51 subfamily A member 1 [KO:K05917] [EC:1.14.13.70]
7108  
TM7SF2; transmembrane 7 superfamily member 2 [KO:K00222] [EC:1.3.1.70]
6307  
MSMO1; methylsterol monooxygenase 1 [KO:K07750] [EC:1.14.13.72]
10826  
FAXDC2; fatty acid hydroxylase domain containing 2 [KO:K07750] [EC:1.14.13.72]
50814  
NSDHL; NAD(P) dependent steroid dehydrogenase-like [KO:K07748] [EC:1.1.1.170]
51478  
HSD17B7; hydroxysteroid (17-beta) dehydrogenase 7 [KO:K13373] [EC:1.1.1.270 1.1.1.62]
10682  
EBP; emopamil binding protein (sterol isomerase) [KO:K01824] [EC:5.3.3.5]
1718  
DHCR24; 24-dehydrocholesterol reductase [KO:K09828] [EC:1.3.1.- 1.3.1.72]
6309  
SC5D; sterol-C5-desaturase [KO:K00227] [EC:1.14.19.20]
1717  
DHCR7; 7-dehydrocholesterol reductase [KO:K00213] [EC:1.3.1.21]
3988  
LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
1056  
CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
8435  
SOAT2; sterol O-acyltransferase 2 [KO:K00637] [EC:2.3.1.26]
6646  
SOAT1; sterol O-acyltransferase 1 [KO:K00637] [EC:2.3.1.26]
120227  
CYP2R1; cytochrome P450 family 2 subfamily R member 1 [KO:K07419] [EC:1.14.14.24]
1594  
CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438] [EC:1.14.13.13]
1591  
CYP24A1; cytochrome P450 family 24 subfamily A member 1 [KO:K07436] [EC:1.14.15.16]
Compound
C00187  
Cholesterol
C00448  
trans,trans-Farnesyl diphosphate
C00751  
Squalene
C01054  
(S)-2,3-Epoxysqualene
C01164  
7-Dehydrocholesterol
C01189  
Lathosterol
C01561  
Calcidiol
C01673  
Calcitriol
C01694  
Ergosterol
C01724  
Lanosterol
C01753  
beta-Sitosterol
C01789  
Campesterol
C01802  
Desmosterol
C01902  
Cycloartenol
C01943  
Obtusifoliol
C02141  
Cycloeucalenol
C02530  
Cholesterol ester
C03428  
Presqualene diphosphate
C03845  
5alpha-Cholest-8-en-3beta-ol
C04525  
Fecosterol
C05103  
4alpha-Methylzymosterol
C05107  
7-Dehydrodesmosterol
C05108  
14-Demethyllanosterol
C05109  
24,25-Dihydrolanosterol
C05437  
Zymosterol
C05439  
5alpha-Cholesta-7,24-dien-3beta-ol
C05440  
Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C05441  
Vitamin D2
C05442  
Stigmasterol
C05443  
Vitamin D3
C07712  
Secalciferol
C08813  
Brassicasterol
C08821  
Isofucosterol
C08830  
24-Methylenecycloartanol
C11455  
4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C11508  
4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C11522  
24-Methylenelophenol
C11523  
24-Ethylidenelophenol
C15776  
4alpha-Methylfecosterol
C15777  
Episterol
C15778  
5,7,24(28)-Ergostatrienol
C15780  
5-Dehydroepisterol
C15781  
24-Methylenecholesterol
C15782  
delta7-Avenasterol
C15783  
5-Dehydroavenasterol
C15808  
4alpha-Methylzymosterol-4-carboxylate
C15816  
3-Keto-4-methylzymosterol
C15915  
4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
C18231  
Calcitetrol
C21106  
24-epi-Campesterol
Reference
  Authors
Koshiba K, Kamiya Y.
  Title
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  Journal
Koudansya saientific:199-138 (2002)
Reference
  Authors
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  Title
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  Journal
Plant Cell 18:1008-22 (2006)
Reference
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
KO pathway
 

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