KEGG   PATHWAY: hsa00230Help
Entry
hsa00230                    Pathway                                

Name
Purine metabolism - Homo sapiens (human)
Class
Metabolism; Nucleotide metabolism
BRITE hierarchy
Pathway map
Purine metabolism
hsa00230

All organismsOrtholog table
Module
PRPP biosynthesis, ribose 5P => PRPP [PATH:hsa00230]
Inosine monophosphate biosynthesis, PRPP + glutamine => IMP [PATH:hsa00230]
Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:hsa00230]
Guanine ribonucleotide biosynthesis IMP => GDP,GTP [PATH:hsa00230]
Disease
H00192  
Xanthinuria
H00194  
Lesch-Nyhan syndrome
H00195  
Adenine phosphoribosyltransferase deficiency
H00196  
Phosphoribosylpyrophosphate synthetase I superactivity
H00197  
Adenylosuccinate lyase deficiency
H00469  
Mitochondrial DNA depletion syndrome (MDS)
H00481  
Cone-rod dystrophy and cone dystrophy
H00494  
Desbuquois syndrome
H00674  
Anemia due to disorders of nucleotide metabolism
H00761  
SEMD, Pakistani type
H00824  
Calcification of joints and arteries
H00837  
Leber congenital amaurosis (LCR)
H00946  
Arts syndrome
H00966  
AICA-ribosiduria
H01002  
Generalized arterial calcification of infancy
H01096  
Pyruvate kinase (PK) deficiency
H01118  
Progressive external ophthalmoplegia (PEO)
H01128  
Reticular dysgenesis
H01394  
Cole disease
H01532  
Gout
H01570  
Autosomal dominant striatal degeneration (ADSD)
Drug
D00155  
Pentostatin (JAN/USAN/INN)
D00224  
Allopurinol (JP17/USP/INN)
D00227  
Aminophylline (USP/INN)
D00231  
Inamrinone (USP)
D00302  
Dipyridamole (JP17/USP/INN)
D00341  
Hydroxyurea (USP)
D00371  
Theophylline (JP17)
D00417  
Milrinone (JAN/USP/INN)
D00528  
Caffeine (USP)
D00718  
Flavoxate hydrochloride (JP17/USAN)
D00752  
Mycophenolate mofetil (JAN/USAN)
D01133  
Pimobendan (JAN/USAN/INN)
D01155  
Gemcitabine hydrochloride (JAN/USAN)
D01198  
Toborinone (JAN/USAN/INN)
D01206  
Febuxostat (JAN/USAN/INN)
D01220  
Trapidil (JP17/INN)
D01392  
Mizoribine (JP17/INN)
D01453  
Caffeine hydrate (JP17)
D01630  
Propentofylline (JAN/INN)
D01690  
Vesnarinone (JAN/USAN/INN)
D01697  
Colforsin daropate hydrochloride (JAN)
D01704  
Cilomilast (JAN/USAN/INN)
D01712  
Theophylline sodium acetate (JAN)
D01771  
Proxyphylline (JAN/INN)
D01783  
Rolipram (JAN/USAN/INN)
D01896  
Cilostazol (JP17/USAN/INN)
D02008  
Tadalafil (JAN/USAN/INN)
D02017  
Oxtriphylline (USP)
D02042  
Olprinone hydrochloride hydrate (JAN)
D02084  
Inamrinone ethylenelactate
D02085  
Milrinone lactate
D02218  
Papaverine hydrochloride (JP17/USP)
D02229  
Sildenafil citrate (JAN/USAN)
D02365  
Oxypurinol (USAN)
D02368  
Gemcitabine (USAN/INN)
D02731  
Vardenafil dihydrochoride (USAN)
D02933  
Anagrelide hydrochloride (USAN)
D02985  
Arofylline (USAN/INN)
D03217  
Avanafil (USAN/INN)
D03260  
Vardenafil hydrochloride hydrate (JAN)
D03378  
Caracemide (USAN)
D03546  
Clofarabine (JAN/USAN/INN)
D03657  
Dasantafil (USAN/INN)
D03828  
Pemetrexed disodium (USAN)
D03898  
Doxofylline (USAN/INN)
D04004  
Enoximone (USAN/INN)
D04185  
Filaminast (USAN/INN)
D04245  
Forodesine hydrochloride (JAN/USAN)
D04508  
Imazodan hydrochloride (USAN)
D04529  
Indolidan (USAN/INN)
D04628  
Isomazole hydrochloride (USAN)
D04720  
Levosimendan (USAN/INN)
D04751  
Lixazinone sulfate (USAN)
D04936  
Merimepodib (USAN/INN)
D05094  
Mycophenolate mofetil hydrochloride (USAN)
D05095  
Mycophenolate sodium (USAN)
D05147  
Nesiritide (USAN/INN)
D05400  
Pelitrexol (USAN/INN)
D05429  
Aminophylline hydrate (JP17)
D05474  
Piclamilast (USAN/INN)
D05744  
Roflumilast (JAN/USAN/INN)
D06103  
Theophylline (USP)
D06104  
Theophylline sodium glycinate (USP)
D06132  
Tibenelast sodium (USAN)
D06503  
Pemetrexed sodium hydrate (JAN)
D06575  
Catramilast (USAN/INN)
D06596  
Forodesine (USAN/INN)
D06612  
Linaclotide acetate (USAN)
D07089  
Moxaverine (INN)
D07425  
Papaverine (BAN)
D07439  
Papaverine sulfate
D07455  
Anagrelide (INN/BAN)
D07472  
Pemetrexed (INN)
D07564  
Allopurinol sodium
D07577  
Cinaciguat (JAN/INN)
D07603  
Caffeine citrate (USP)
D07961  
Flavoxate (INN)
D08238  
Moxaverine hydrochloride
D08294  
Olprinone (INN)
D08514  
Sildenafil (INN)
D08668  
Vardenafil (INN)
D08860  
Apremilast (JAN/USAN)
D09020  
Tofimilast (INN/USAN)
D09355  
Linaclotide (JAN/USAN)
D09572  
Riociguat (JAN/INN)
D09621  
Gisadenafil (USAN/INN)
D09622  
Gisadenafil besylate (USAN)
D09786  
Topiroxostat (JAN/INN)
D09948  
Plecanatide (USAN/INN)
D09989  
Vardenafil hydrochloride (USAN)
D10027  
Udenafil (USAN/INN)
D10063  
Cenderitide (USAN)
D10222  
Gemcitabine elaidate (USAN/INN)
D10255  
Anagrelide hydrochloride hydrate (JAN)
D10431  
Ulodesine (USAN)
D10432  
Ulodesine succinate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
53343  
NUDT9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
56985  
ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.53 3.6.1.16 3.6.1.13]
11164  
NUDT5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.- 3.6.1.58 3.6.1.13]
5236  
PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
55276  
PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.7 5.4.2.2]
221823  
PRPS1L1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
5634  
PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
5631  
PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
5471  
PPAT; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
2618  
GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.3.1 2.1.2.2 6.3.4.13]
5198  
PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
10606  
PAICS; phosphoribosylaminoimidazole carboxylase [KO:K01587] [EC:6.3.2.6 4.1.1.21]
158  
ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
471  
ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:3.5.4.10 2.1.2.3]
353  
APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
22978  
NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
84618  
NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
93034  
NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
30833  
NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
56953  
NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
51251  
NT5C3A; 5'-nucleotidase, cytosolic IIIA [KO:K01081] [EC:3.1.3.5]
115024  
NT5C3B; 5'-nucleotidase, cytosolic IIIB [KO:K01081] [EC:3.1.3.5]
NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
4907  
NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
4860  
PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
3251  
HPRT1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
3614  
IMPDH1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
3615  
IMPDH2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
10201  
NME6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
29922  
NME7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
4831  
NME2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
4833  
NME4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
4830  
NME1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
4832  
NME3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
654364  
NME1-NME2; NME1-NME2 readthrough [KO:K00940] [EC:2.7.4.6]
221264  
AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.6 2.7.4.3]
956  
ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
377841  
ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
953  
ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
124583  
CANT1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
9583  
ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
957  
ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
955  
ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
131870  
NUDT16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.64 3.6.1.62]
3704  
ITPA; inosine triphosphatase [KO:K01519] [EC:3.6.1.-]
7498  
XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.3.2 1.17.1.4]
318  
NUDT2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
8833  
GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
2766  
GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
51292  
GMPR2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
9615  
GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
2987  
GUK1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
5315  
PKM; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
5313  
PKLR; pyruvate kinase, liver and RBC [KO:K12406] [EC:2.7.1.40]
6240  
RRM1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
50484  
RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
6241  
RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
1716  
DGUOK; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
25885  
POLR1A; polymerase (RNA) I subunit A [KO:K02999] [EC:2.7.7.6]
84172  
POLR1B; polymerase (RNA) I subunit B [KO:K03002] [EC:2.7.7.6]
30834  
ZNRD1; zinc ribbon domain containing 1 [KO:K03000]
221830  
TWISTNB; TWIST neighbor [KO:K03004]
64425  
POLR1E; polymerase (RNA) I subunit E [KO:K03005]
5430  
POLR2A; polymerase (RNA) II subunit A [KO:K03006] [EC:2.7.7.6]
5431  
POLR2B; polymerase (RNA) II subunit B [KO:K03010] [EC:2.7.7.6]
5432  
POLR2C; polymerase (RNA) II subunit C [KO:K03011]
5433  
POLR2D; polymerase (RNA) II subunit D [KO:K03012]
5434  
POLR2E; polymerase (RNA) II subunit E [KO:K03013]
5435  
POLR2F; polymerase (RNA) II subunit F [KO:K03014]
5436  
POLR2G; polymerase (RNA) II subunit G [KO:K03015]
5437  
POLR2H; polymerase (RNA) II subunit H [KO:K03016]
5438  
POLR2I; polymerase (RNA) II subunit I [KO:K03017]
5441  
POLR2L; polymerase (RNA) II subunit L [KO:K03007]
5439  
POLR2J; polymerase (RNA) II subunit J [KO:K03008]
548644  
POLR2J3; polymerase (RNA) II subunit J3 [KO:K03008]
246721  
POLR2J2; polymerase (RNA) II subunit J2 [KO:K03008]
5440  
POLR2K; polymerase (RNA) II subunit K [KO:K03009]
11128  
POLR3A; polymerase (RNA) III subunit A [KO:K03018] [EC:2.7.7.6]
55703  
POLR3B; polymerase (RNA) III subunit B [KO:K03021] [EC:2.7.7.6]
10623  
POLR3C; polymerase (RNA) III subunit C [KO:K03023]
661  
POLR3D; polymerase (RNA) III subunit D [KO:K03026]
55718  
POLR3E; polymerase (RNA) III subunit E [KO:K14721]
DNA-directed RNA polymerase III subunit RPC5; K14721 DNA-directed RNA polymerase III subunit RPC5 [KO:K14721]
9533  
POLR1C; polymerase (RNA) I subunit C [KO:K03027]
51728  
POLR3K; polymerase (RNA) III subunit K [KO:K03019]
51082  
POLR1D; polymerase (RNA) I subunit D [KO:K03020]
171568  
POLR3H; polymerase (RNA) III subunit H [KO:K03022]
84265  
POLR3GL; polymerase (RNA) III subunit G like [KO:K03024]
10622  
POLR3G; polymerase (RNA) III subunit G [KO:K03024]
10621  
POLR3F; polymerase (RNA) III subunit F [KO:K03025]
5422  
POLA1; polymerase (DNA) alpha 1, catalytic subunit [KO:K02320] [EC:2.7.7.7]
23649  
POLA2; polymerase (DNA) alpha 2, accessory subunit [KO:K02321]
5557  
PRIM1; primase (DNA) subunit 1 [KO:K02684] [EC:2.7.7.-]
5558  
PRIM2; primase (DNA) subunit 2 [KO:K02685] [EC:2.7.7.-]
5424  
POLD1; polymerase (DNA) delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425  
POLD2; polymerase (DNA) delta 2, accessory subunit [KO:K02328]
10714  
POLD3; polymerase (DNA) delta 3, accessory subunit [KO:K03504]
57804  
POLD4; polymerase (DNA) delta 4, accessory subunit [KO:K03505]
5426  
POLE; polymerase (DNA) epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
5427  
POLE2; polymerase (DNA) epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
54107  
POLE3; polymerase (DNA) epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
56655  
POLE4; polymerase (DNA) epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
374659  
HDDC3; HD domain containing 3 [KO:K01139] [EC:3.1.7.2]
58497  
PRUNE1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
107  
ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
108  
ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
115  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
55811  
ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
2977  
GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
2982  
GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
2983  
GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
2984  
GUCY2C; guanylate cyclase 2C [KO:K12320] [EC:4.6.1.2]
3000  
GUCY2D; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
2986  
GUCY2F; guanylate cyclase 2F, retinal [KO:K12322] [EC:4.6.1.2]
4881  
NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
4882  
NPR2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
5136  
PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
5153  
PDE1B; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
5137  
PDE1C; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
5138  
PDE2A; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
5139  
PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
5140  
PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
8654  
PDE5A; phosphodiesterase 5A [KO:K13762] [EC:3.1.4.35]
5145  
PDE6A; phosphodiesterase 6A [KO:K08718] [EC:3.1.4.35]
5158  
PDE6B; phosphodiesterase 6B [KO:K13756] [EC:3.1.4.35]
5146  
PDE6C; phosphodiesterase 6C [KO:K13757] [EC:3.1.4.35]
5147  
PDE6D; phosphodiesterase 6D [KO:K13758]
5148  
PDE6G; phosphodiesterase 6G [KO:K13759]
5149  
PDE6H; phosphodiesterase 6H [KO:K13760]
5152  
PDE9A; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
10846  
PDE10A; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.35 3.1.4.17]
50940  
PDE11A; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.35 3.1.4.17]
122622  
ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]
159  
ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
271  
AMPD2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
272  
AMPD3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
270  
AMPD1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
132  
ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
1633  
DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74]
100  
ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
51816  
CECR1; cat eye syndrome chromosome region, candidate 1 [KO:K19572] [EC:3.5.4.4]
122481  
AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
205  
AK4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
26289  
AK5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
204  
AK2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
203  
AK1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
390877  
adenylate kinase isoenzyme 1-like; K00939 adenylate kinase [EC:2.7.4.3] [KO:K00939] [EC:2.7.4.3]
158067  
AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
50808  
AK3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
954  
ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.3]
84284  
NTPCR; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
87178  
PNPT1; polyribonucleotide nucleotidyltransferase 1 [KO:K00962] [EC:2.7.7.8]
5141  
PDE4A; phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
5142  
PDE4B; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
5143  
PDE4C; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
5144  
PDE4D; phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
5150  
PDE7A; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
27115  
PDE7B; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
8622  
PDE8B; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
5151  
PDE8A; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
2272  
FHIT; fragile histidine triad [KO:K01522] [EC:3.6.1.29]
22875  
ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) [KO:K18424] [EC:3.6.1.29]
9060  
PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.1.25 2.7.7.4]
9061  
PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.1.25 2.7.7.4]
5167  
ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
5169  
ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
646625  
URAD; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [KO:K13485] [EC:4.1.1.97]
55821  
ALLC; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  
ATP
C00008  
ADP
C00011  
CO2
C00014  
Ammonia
C00020  
AMP
C00035  
GDP
C00037  
Glycine
C00039  
DNA
C00044  
GTP
C00046  
RNA
C00048  
Glyoxylate
C00053  
3'-Phosphoadenylyl sulfate
C00054  
Adenosine 3',5'-bisphosphate
C00059  
Sulfate
C00064  
L-Glutamine
C00081  
ITP
C00086  
Urea
C00104  
IDP
C00117  
D-Ribose 5-phosphate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00130  
IMP
C00131  
dATP
C00144  
GMP
C00147  
Adenine
C00169  
Carbamoyl phosphate
C00206  
dADP
C00212  
Adenosine
C00224  
Adenylyl sulfate
C00242  
Guanine
C00262  
Hypoxanthine
C00286  
dGTP
C00294  
Inosine
C00301  
ADP-ribose
C00330  
Deoxyguanosine
C00360  
dAMP
C00361  
dGDP
C00362  
dGMP
C00366  
Urate
C00385  
Xanthine
C00387  
Guanosine
C00499  
Allantoate
C00559  
Deoxyadenosine
C00575  
3',5'-Cyclic AMP
C00603  
(-)-Ureidoglycolate
C00620  
alpha-D-Ribose 1-phosphate
C00655  
Xanthosine 5'-phosphate
C00700  
XTP
C00802  
Oxalureate
C00942  
3',5'-Cyclic GMP
C01228  
Guanosine 3',5'-bis(diphosphate)
C01260  
P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  
P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  
dIDP
C01345  
dITP
C01367  
3'-AMP
C01762  
Xanthosine
C02091  
(S)-Ureidoglycine
C02348  
(R)(-)-Allantoin
C02350  
(S)-Allantoin
C02353  
2',3'-Cyclic AMP
C02718  
N-Formiminoglycine
C03090  
5-Phosphoribosylamine
C03373  
Aminoimidazole ribotide
C03483  
Adenosine tetraphosphate
C03614  
Inosine 5'-tetraphosphate
C03794  
N6-(1,2-Dicarboxyethyl)-AMP
C03838  
5'-Phosphoribosylglycinamide
C04051  
5-Amino-4-imidazolecarboxyamide
C04376  
5'-Phosphoribosyl-N-formylglycinamide
C04392  
P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  
Guanosine 3'-diphosphate 5'-triphosphate
C04640  
2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  
1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  
1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  
1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  
5-Aminoimidazole
C05512  
Deoxyinosine
C05513  
Urate-3-ribonucleoside
C05515  
5-Ureido-4-imidazole carboxylate
C05516  
5-Amino-4-imidazole carboxylate
C05993  
Acetyl adenylate
C06193  
Guanosine 3'-phosphate
C06194  
2',3'-Cyclic GMP
C06195  
Imidazolone
C06196  
2'-Deoxyinosine 5'-phosphate
C06197  
P1,P3-Bis(5'-adenosyl) triphosphate
C06433  
5'-Benzoylphosphoadenosine
C06435  
5'-Butyrylphosphoinosine
C11821  
5-Hydroxyisourate
C12248  
5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
Reference
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
Reference
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
KO pathway
 

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