KEGG   PATHWAY: hsa00260Help
Entry
hsa00260                    Pathway                                

Name
Glycine, serine and threonine metabolism - Homo sapiens (human)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Glycine, serine and threonine metabolism
hsa00260

All organismsOrtholog table
Module
Serine biosynthesis, glycerate-3P => serine [PATH:hsa00260]
Disease
H00117  
Primary hyperoxaluria (HP)
H00182  
Cystathioninuria
H00183  
Homocystinuria
H00184  
Hypermethioninemia
H00191  
Nonketotic hyperglycinemia
H00834  
Guanidinoacetate methyltransferase (GAMT) deficiency
H00849  
Creatine deficiency syndrome
H01003  
Dimethylglycine dehydrogenase deficiency (DMGDHD)
H01079  
3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency
H01082  
Phosphoserine aminotransferase (PSAT) deficiency
Drug
D00505  
Phenelzine sulfate (USP)
D00785  
Selegiline hydrochloride (JAN/USP)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesilate (JAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04681  
Lazabemide (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D08085  
Iproniazid phosphate
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
Other DBs
Organism
Homo sapiens (human) [GN:hsa]
Gene
6472  
SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
6470  
SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
5723  
PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
29968  
PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
26227  
PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95]
132158  
GLYCTK; glycerate kinase [KO:K15788] [EC:2.7.1.31]
5223  
PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
5224  
PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
441531  
PGAM4; phosphoglycerate mutase family member 4 [KO:K01834] [EC:5.4.2.11]
669  
BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:3.1.3.13 5.4.2.11 5.4.2.4]
9380  
GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.81 1.1.1.79]
23464  
GCAT; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
211  
ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
212  
ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
8639  
AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
314  
AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
2731  
GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
275  
AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
1738  
DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
2653  
GCSH; glycine cleavage system protein H [KO:K02437]
1610  
DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
189  
AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.51 2.6.1.45 2.6.1.44]
64902  
AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.40 2.6.1.44]
2628  
GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
2593  
GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
55349  
CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
501  
ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
635  
BHMT; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:2.1.1.5]
29958  
DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
51268  
PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.7 1.5.3.1]
1757  
SARDH; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
27232  
GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
875  
CBS; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
CBSL; cystathionine-beta-synthase like [KO:K01697] [EC:4.2.1.22]
1491  
CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
10993  
SDS; serine dehydratase [KO:K17989] [EC:4.3.1.19 4.3.1.17]
113675  
SDSL; serine dehydratase like [KO:K17989] [EC:4.3.1.19 4.3.1.17]
63826  
SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  
CO2
C00014  
Ammonia
C00022  
Pyruvate
C00037  
Glycine
C00048  
Glyoxylate
C00049  
L-Aspartate
C00065  
L-Serine
C00078  
L-Tryptophan
C00097  
L-Cysteine
C00101  
Tetrahydrofolate
C00109  
2-Oxobutanoate
C00114  
Choline
C00143  
5,10-Methylenetetrahydrofolate
C00168  
Hydroxypyruvate
C00188  
L-Threonine
C00197  
3-Phospho-D-glycerate
C00213  
Sarcosine
C00258  
D-Glycerate
C00263  
L-Homoserine
C00300  
Creatine
C00430  
5-Aminolevulinate
C00441  
L-Aspartate 4-semialdehyde
C00546  
Methylglyoxal
C00576  
Betaine aldehyde
C00581  
Guanidinoacetate
C00631  
2-Phospho-D-glycerate
C00719  
Betaine
C00740  
D-Serine
C00986  
1,3-Diaminopropane
C01005  
O-Phospho-L-serine
C01026  
N,N-Dimethylglycine
C01102  
O-Phospho-L-homoserine
C01242  
S-Aminomethyldihydrolipoylprotein
C01726  
D-Lombricine
C01888  
Aminoacetone
C02051  
Lipoylprotein
C02291  
L-Cystathionine
C02737  
Phosphatidylserine
C02855  
N-Phospho-D-lombricine
C02972  
Dihydrolipoylprotein
C03082  
4-Phospho-L-aspartate
C03194  
(R)-1-Aminopropan-2-ol
C03232  
3-Phosphonooxypyruvate
C03283  
L-2,4-Diaminobutanoate
C03508  
L-2-Amino-3-oxobutanoic acid
C05519  
L-Allothreonine
C06231  
Ectoine
C06442  
N(gamma)-Acetyldiaminobutyrate
C16432  
5-Hydroxyectoine
C19929  
N-alpha-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
KO pathway
 

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