KEGG   PATHWAY: hsa00260Help
hsa00260                    Pathway                                

Glycine, serine and threonine metabolism - Homo sapiens (human)
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
hsa00260  Glycine, serine and threonine metabolism

Ortholog table
hsa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hsa00260]
H00117  Primary hyperoxaluria (HP)
H00182  Cystathioninuria
H00183  Homocystinuria
H00184  Hypermethioninemia
H00191  Nonketotic hyperglycinemia
H00834  Guanidinoacetate methyltransferase (GAMT) deficiency
H00849  Creatine deficiency syndrome
H01003  Dimethylglycine dehydrogenase deficiency (DMGDHD)
H01079  3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency
H01082  Phosphoserine aminotransferase (PSAT) deficiency
H01951  Glycogen storage disease type X
D00505  Phenelzine sulfate (USP)
D00826  Tranylcypromine sulfate (USP XXI)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D02581  Cimoxatone (INN)
D03239  Ladostigil tartrate (USAN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D05033  Milacemide hydrochloride (USAN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
Other DBs
BSID: 82949
GO: 0006544 0006563 0070178 0006566
Homo sapiens (human) [GN:hsa]
6472  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:]
6470  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:]
189  AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:]
9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:]
132158  GLYCTK; glycerate kinase [KO:K11529] [EC:]
5223  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:]
5224  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:]
441531  PGAM4; phosphoglycerate mutase family member 4 [KO:K01834] [EC:]
669  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:]
26227  PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:]
29968  PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:]
5723  PSPH; phosphoserine phosphatase [KO:K01079] [EC:]
23464  GCAT; glycine C-acetyltransferase [KO:K00639] [EC:]
211  ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:]
212  ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:]
8639  AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:]
314  AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:]
2731  GLDC; glycine decarboxylase [KO:K00281] [EC:]
275  AMT; aminomethyltransferase [KO:K00605] [EC:]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:]
2653  GCSH; glycine cleavage system protein H [KO:K02437]
1610  DAO; D-amino acid oxidase [KO:K00273] [EC:]
64902  AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:]
2628  GATM; glycine amidinotransferase [KO:K00613] [EC:]
2593  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:]
55349  CHDH; choline dehydrogenase [KO:K00108] [EC:]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:]
635  BHMT; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:]
29958  DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:]
51268  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:]
1757  SARDH; sarcosine dehydrogenase [KO:K00314] [EC:]
27232  GNMT; glycine N-methyltransferase [KO:K00552] [EC:]
875  CBS; cystathionine-beta-synthase [KO:K01697] [EC:]
102724560  CBSL; cystathionine-beta-synthase like [KO:K01697] [EC:]
1491  CTH; cystathionine gamma-lyase [KO:K01758] [EC:]
10993  SDS; serine dehydratase [KO:K17989] [EC:]
113675  SDSL; serine dehydratase like [KO:K17989] [EC:]
63826  SRR; serine racemase [KO:K12235] [EC:]
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  S-Aminomethyldihydrolipoylprotein
C01726  D-Lombricine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02855  N-Phospho-D-lombricine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Kuhlmann AU, Bremer E.
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
Appl Environ Microbiol 68:772-83 (2002)
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
Appl Environ Microbiol 65:3774-9 (1999)
Bursy J, Pierik AJ, Pica N, Bremer E.
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
J Biol Chem 282:31147-55 (2007)
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
J Bacteriol 188:3774-84 (2006)
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Eukaryot Cell 3:1287-96 (2004)
Rees WD, Hay SM
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
Biochem J 309 ( Pt 3):999-1007 (1995)
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
Biochim Biophys Acta 1544:28-41 (2001)
Chen X, Jhee KH, Kruger WD
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
J Biol Chem 279:52082-6 (2004)
KO pathway

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