KEGG   PATHWAY: hsa00330Help
Entry
hsa00330                    Pathway                                

Name
Arginine and proline metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Arginine and proline metabolism
hsa00330

All organismsOrtholog table
Module
Proline biosynthesis, glutamate => proline [PATH:hsa00330]
Creatine pathway [PATH:hsa00330]
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:hsa00330]
Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:hsa00330]
GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:hsa00330]
Disease
H00186  
Hyperargininemia
H00189  
Ornithinaemia
H00190  
Hyperprolinemia (HP)
H00597  
Snyder-Robinson syndrome
H00834  
Guanidinoacetate methyltransferase (GAMT) deficiency
H00849  
Creatine deficiency syndrome
Drug
D00123  
Cyanamide (JP17)
D00131  
Disulfiram (JP17/USP/INN)
D00505  
Phenelzine sulfate (USP)
D00785  
Selegiline hydrochloride (JAN/USP)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04681  
Lazabemide (USAN/INN)
D04793  
Lufironil (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D08085  
Iproniazid phosphate
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
D09018  
Tilarginine acetate (USAN)
D10386  
Cindunistat (USAN/INN)
D10419  
Cindunistat hydrochloride maleate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2628  
GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
2593  
GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
1158  
CKM; creatine kinase, M-type [KO:K00933] [EC:2.7.3.2]
548596  
CKMT1A; creatine kinase, mitochondrial 1A [KO:K00933] [EC:2.7.3.2]
1160  
CKMT2; creatine kinase, mitochondrial 2 [KO:K00933] [EC:2.7.3.2]
1152  
CKB; creatine kinase B [KO:K00933] [EC:2.7.3.2]
1159  
CKMT1B; creatine kinase, mitochondrial 1B [KO:K00933] [EC:2.7.3.2]
113451  
AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
79814  
AGMAT; agmatinase [KO:K01480] [EC:3.5.3.11]
4953  
ODC1; ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
6723  
SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
6611  
SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
262  
AMD1; adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
26  
AOC1; amine oxidase, copper containing 1 [KO:K11182] [EC:1.4.3.22]
54498  
SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.- 1.5.3.16]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
84735  
CNDP1; carnosine dipeptidase 1 (metallopeptidase M20 family) [KO:K05604] [EC:3.4.13.20]
55748  
CNDP2; CNDP dipeptidase 2 (metallopeptidase M20 family) [KO:K08660] [EC:3.4.13.18]
57571  
CARNS1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
112483  
SAT2; spermidine/spermine N1-acetyltransferase family member 2 [KO:K00657] [EC:2.3.1.57]
6303  
SAT1; spermidine/spermine N1-acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
4842  
NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
4843  
NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
4846  
NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
384  
ARG2; arginase 2 [KO:K01476] [EC:3.5.3.1]
383  
ARG1; arginase 1 [KO:K01476] [EC:3.5.3.1]
4942  
OAT; ornithine aminotransferase [KO:K00819] [EC:2.6.1.13]
65263  
PYCRL; pyrroline-5-carboxylate reductase-like [KO:K00286] [EC:1.5.1.2]
29920  
PYCR2; pyrroline-5-carboxylate reductase family member 2 [KO:K00286] [EC:1.5.1.2]
5831  
PYCR1; pyrroline-5-carboxylate reductase 1 [KO:K00286] [EC:1.5.1.2]
5625  
PRODH; proline dehydrogenase 1 [KO:K00318] [EC:1.5.-.-]
proline dehydrogenase 1; K00318 proline dehydrogenase [EC:1.5.-.-] [KO:K00318] [EC:1.5.-.-]
8659  
ALDH4A1; aldehyde dehydrogenase 4 family member A1 [KO:K00294] [EC:1.2.1.88]
5832  
ALDH18A1; aldehyde dehydrogenase 18 family member A1 [KO:K12657] [EC:1.2.1.41 2.7.2.11]
51056  
LAP3; leucine aminopeptidase 3 [KO:K11142] [EC:3.4.11.5 3.4.11.1]
8974  
P4HA2; prolyl 4-hydroxylase subunit alpha 2 [KO:K00472] [EC:1.14.11.2]
283208  
P4HA3; prolyl 4-hydroxylase subunit alpha 3 [KO:K00472] [EC:1.14.11.2]
5033  
P4HA1; prolyl 4-hydroxylase subunit alpha 1 [KO:K00472] [EC:1.14.11.2]
58510  
PRODH2; proline dehydrogenase 2 [KO:K11394] [EC:1.5.-.-]
2805  
GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
2806  
GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
112817  
HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
1610  
DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
112849  
L3HYPDH; trans-L-3-hydroxyproline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  
Peptide
C00019  
S-Adenosyl-L-methionine
C00022  
Pyruvate
C00025  
L-Glutamate
C00048  
Glyoxylate
C00062  
L-Arginine
C00077  
L-Ornithine
C00086  
Urea
C00134  
Putrescine
C00148  
L-Proline
C00179  
Agmatine
C00213  
Sarcosine
C00223  
p-Coumaroyl-CoA
C00300  
Creatine
C00315  
Spermidine
C00334  
4-Aminobutanoate
C00406  
Feruloyl-CoA
C00431  
5-Aminopentanoate
C00433  
2,5-Dioxopentanoate
C00436  
N-Carbamoylputrescine
C00441  
L-Aspartate 4-semialdehyde
C00533  
Nitric oxide
C00555  
4-Aminobutyraldehyde
C00581  
Guanidinoacetate
C00750  
Spermine
C00763  
D-Proline
C00791  
Creatinine
C00884  
Homocarnosine
C00986  
1,3-Diaminopropane
C01035  
4-Guanidinobutanoate
C01043  
N-Carbamoylsarcosine
C01110  
5-Amino-2-oxopentanoic acid
C01137  
S-Adenosylmethioninamine
C01157  
Hydroxyproline
C01165  
L-Glutamate 5-semialdehyde
C01682  
Nopaline
C01877  
4-Oxoproline
C02305  
Phosphocreatine
C02565  
N-Methylhydantoin
C02647  
4-Guanidinobutanal
C02714  
N-Acetylputrescine
C02946  
4-Acetamidobutanoate
C03078  
4-Guanidinobutanamide
C03166  
Phosphoguanidinoacetate
C03287  
L-Glutamyl 5-phosphate
C03296  
N2-Succinyl-L-arginine
C03375  
Norspermidine
C03415  
N2-Succinyl-L-ornithine
C03440  
cis-4-Hydroxy-D-proline
C03564  
1-Pyrroline-2-carboxylate
C03771  
5-Guanidino-2-oxopentanoate
C03912  
(S)-1-Pyrroline-5-carboxylate
C04137  
D-Octopine
C04281  
L-1-Pyrroline-3-hydroxy-5-carboxylate
C04282  
1-Pyrroline-4-hydroxy-2-carboxylate
C04498  
p-Coumaroylagmatine
C05147  
trans-3-Hydroxy-L-proline
C05931  
N-Succinyl-L-glutamate
C05932  
N-Succinyl-L-glutamate 5-semialdehyde
C05933  
N(omega)-Hydroxyarginine
C05936  
N4-Acetylaminobutanal
C05938  
L-4-Hydroxyglutamate semialdehyde
C05939  
Linatine
C05941  
2-Oxo-4-hydroxy-5-aminovalerate
C05942  
Pyrrole-2-carboxylate
C05945  
L-Arginine phosphate
C05946  
(4R)-4-Hydroxy-2-oxoglutarate
C05947  
L-erythro-4-Hydroxyglutamate
C10497  
Feruloylputrescine
C15699  
gamma-L-Glutamylputrescine
C15700  
gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  
4-(L-gamma-Glutamylamino)butanoate
C18172  
Carboxyspermidine
C18174  
Carboxynorspermidine
C18325  
Feruloylagmatine
C18326  
p-Coumaroylputrescine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
Reference
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
Reference
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
KO pathway
 

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