KEGG   PATHWAY: hsa00350Help
Entry
hsa00350                    Pathway                                

Name
Tyrosine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Tyrosine metabolism
hsa00350

All organismsOrtholog table
Module
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:hsa00350]
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:hsa00350]
Tyrosine degradation, tyrosine => homogentisate [PATH:hsa00350]
Disease
H00163  
Alkaptonuria
H00165  
Tyrosinemia
H00168  
Oculocutaneous albinism (OCA)
H00251  
Thyroid dyshormonogenesis
H00548  
Brunner syndrome
H00831  
Primary dystonia
H01005  
Dopamine beta-hydroxylase deficiency
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
Drug
D00073  
Hydroquinone (USP)
D00152  
Phloroglucinol (JAN)
D00401  
Thiamazole (JP16/INN)
D00405  
Methyldopa hydrate (JP16)
D00505  
Phenelzine sulfate (USP)
D00558  
Carbidopa hydrate (JP16)
D00562  
Propylthiouracil (JP16/USP/INN)
D00707  
Fomepizole (JAN/USAN/INN)
D00762  
Metyrosine (USP)
D00781  
Entacapone (JAN/USAN/INN)
D00785  
Selegiline hydrochloride (JAN/USP)
D00786  
Tolcapone (JAN/USAN/INN)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01259  
Flopropione (JP16/INN)
D01304  
Amezinium metilsulfate (JAN)
D01653  
Benserazide hydrochloride (JP16)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03082  
Benserazide (USAN/INN)
D03239  
Ladostigil tartrate (USAN)
D03241  
Nitecapone (INN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04681  
Lazabemide (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D05177  
Nitisinone (JAN/USAN/INN)
D07231  
Methylthiouracil (INN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D07519  
Benzylthiouracil
D08085  
Iproniazid phosphate
D08205  
Methyldopa (INN)
D08349  
Phenelzine (BAN)
D08369  
Polyphloroglucinol phosphate
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2805  
GOT1; glutamic-oxaloacetic transaminase 1, soluble [KO:K14454] [EC:2.6.1.1]
2806  
GOT2; glutamic-oxaloacetic transaminase 2, mitochondrial [KO:K14455] [EC:2.6.1.1]
6898  
TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
259307  
IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
3242  
HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
3081  
HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
2954  
GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
2184  
FAH; fumarylacetoacetate hydrolase (fumarylacetoacetase) [KO:K01555] [EC:3.7.1.2]
7299  
TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
7054  
TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
1638  
DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
7306  
TYRP1; tyrosinase-related protein 1 [KO:K00506] [EC:1.14.18.-]
1644  
DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) [KO:K01593] [EC:4.1.1.28]
1621  
DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) [KO:K00503] [EC:1.14.17.1]
5409  
PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
1312  
COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
8639  
AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
314  
AOC2; amine oxidase, copper containing 2 (retina-specific) [KO:K00276] [EC:1.4.3.21]
221  
ALDH3B1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:1.2.1.5]
222  
ALDH3B2; aldehyde dehydrogenase 3 family, member B2 [KO:K00129] [EC:1.2.1.5]
220  
ALDH1A3; aldehyde dehydrogenase 1 family, member A3 [KO:K00129] [EC:1.2.1.5]
218  
ALDH3A1; aldehyde dehydrogenase 3 family, member A1 [KO:K00129] [EC:1.2.1.5]
124  
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130  
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
7173  
TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
316  
AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
81889  
FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
4282  
MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) [KO:K07253] [EC:5.3.2.1]
Compound
C00022  
Pyruvate
C00042  
Succinate
C00082  
L-Tyrosine
C00122  
Fumarate
C00146  
Phenol
C00164  
Acetoacetate
C00232  
Succinate semialdehyde
C00355  
3,4-Dihydroxy-L-phenylalanine
C00483  
Tyramine
C00530  
Hydroquinone
C00544  
Homogentisate
C00547  
L-Noradrenaline
C00628  
2,5-Dihydroxybenzoate
C00642  
4-Hydroxyphenylacetate
C00788  
L-Adrenaline
C00811  
4-Coumarate
C00822  
Dopaquinone
C01036  
4-Maleylacetoacetate
C01060  
3,5-Diiodo-L-tyrosine
C01061  
4-Fumarylacetoacetate
C01161  
3,4-Dihydroxyphenylacetate
C01179  
3-(4-Hydroxyphenyl)pyruvate
C01207  
3-(3,4-Dihydroxyphenyl)lactate
C01693  
L-Dopachrome
C01829  
Thyroxine
C01850  
Rosmarinate
C02167  
Maleylpyruvate
C02442  
N-Methyltyramine
C02465  
Triiodothyronine
C02514  
3-Fumarylpyruvate
C02515  
3-Iodo-L-tyrosine
C03063  
2-Oxohept-3-enedioate
C03077  
4-Chlorophenylacetate
C03672  
3-(4-Hydroxyphenyl)lactate
C03758  
Dopamine
C03765  
4-Hydroxyphenylacetaldehyde
C04043  
3,4-Dihydroxyphenylacetaldehyde
C04045  
3-(3,4-Dihydroxyphenyl)pyruvate
C04052  
5-Carboxy-2-oxohept-3-enedioate
C04185  
5,6-Dihydroxyindole-2-carboxylate
C04186  
5-Carboxymethyl-2-hydroxymuconate
C04368  
3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  
2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  
4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  
5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  
4-Hydroxyphenylacetyl-CoA
C05350  
2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  
3,4-Dihydroxyphenylethyleneglycol
C05577  
3,4-Dihydroxymandelaldehyde
C05578  
5,6-Dihydroxyindole
C05579  
Indole-5,6-quinone
C05580  
3,4-Dihydroxymandelate
C05581  
3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  
Homovanillate
C05583  
3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  
3-Methoxy-4-hydroxymandelate
C05585  
Gentisate aldehyde
C05587  
3-Methoxytyramine
C05588  
L-Metanephrine
C05589  
L-Normetanephrine
C05593  
3-Hydroxyphenylacetate
C05594  
3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  
4-Hydroxyphenylacetylglutamic acid
C05596  
p-Hydroxyphenylacetylglycine
C05600  
2-Hydroxyhepta-2,4-dienedioate
C05604  
2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  
4-Hydroxyphenylethanol
C06046  
Salidroside
C06047  
Stizolobate
C06048  
Stizolobinate
C06199  
Hordenine
C06201  
2,4-Dihydroxyhept-2-enedioate
C10447  
3,4-Dihydroxyphenylpropanoate
C17935  
Cysteinyldopa
C17936  
Phaeomelanin
C17937  
Eumelanin
C17938  
5,6-Indolequinone-2-carboxylic acid
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
KO pathway
 

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