KEGG   PATHWAY: hsa00360Help
Entry
hsa00360                    Pathway                                

Name
Phenylalanine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Phenylalanine metabolism
hsa00360

All organismsOrtholog table
Disease
H00165  
Tyrosinemia
Drug
D00405  
Methyldopa (USP)
D00505  
Phenelzine sulfate (USP)
D00558  
Carbidopa (USP)
D00785  
Selegiline hydrochloride (JAN/USP)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01653  
Benserazide hydrochloride (JP17)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03082  
Benserazide (USAN/INN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04681  
Lazabemide (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D05177  
Nitisinone (JAN/USAN/INN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D08085  
Iproniazid phosphate
D08205  
Methyldopa (INN)
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
5053  
PAH; phenylalanine hydroxylase [KO:K00500] [EC:1.14.16.1]
1644  
DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28]
8639  
AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
314  
AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
221  
ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  
ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
220  
ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K00129] [EC:1.2.1.5]
218  
ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
10249  
GLYAT; glycine-N-acyltransferase [KO:K00628] [EC:2.3.1.13]
2805  
GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
2806  
GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
6898  
TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
259307  
IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
3242  
HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
4282  
MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) [KO:K07253] [EC:5.3.2.1]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00042  
Succinate
C00079  
L-Phenylalanine
C00082  
L-Tyrosine
C00083  
Malonyl-CoA
C00084  
Acetaldehyde
C00091  
Succinyl-CoA
C00122  
Fumarate
C00156  
4-Hydroxybenzoate
C00166  
Phenylpyruvate
C00180  
Benzoate
C00223  
p-Coumaroyl-CoA
C00323  
Caffeoyl-CoA
C00406  
Feruloyl-CoA
C00423  
trans-Cinnamate
C00512  
S-Benzoate coenzyme A
C00582  
Phenylacetyl-CoA
C00596  
2-Hydroxy-2,4-pentadienoate
C00601  
Phenylacetaldehyde
C00630  
2-Methylpropanoyl-CoA
C00642  
4-Hydroxyphenylacetate
C00755  
4-Hydroxy-3-methoxy-benzaldehyde
C00805  
Salicylate
C00811  
4-Coumarate
C01198  
3-(2-Hydroxyphenyl)propanoate
C01575  
Ephedrine
C01586  
Hippurate
C01772  
trans-2-Hydroxycinnamate
C02137  
alpha-Oxo-benzeneacetic acid
C02232  
3-Oxoadipyl-CoA
C02265  
D-Phenylalanine
C02505  
2-Phenylacetamide
C02763  
2-Hydroxy-3-phenylpropenoate
C02765  
(+)-Pseudoephedrine
C03519  
N-Acetyl-L-phenylalanine
C03589  
4-Hydroxy-2-oxopentanoate
C04044  
3-(2,3-Dihydroxyphenyl)propanoate
C04148  
Phenylacetylglutamine
C04351  
(R)-2-Methylimino-1-phenylpropan-1-ol
C04479  
2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  
Phenethylamine
C05593  
3-Hydroxyphenylacetate
C05598  
Phenylacetylglycine
C05607  
Phenyllactate
C05620  
N-Acetyl-D-phenylalanine
C05629  
Phenylpropanoate
C05852  
2-Hydroxyphenylacetate
C05853  
Phenylethyl alcohol
C06207  
2,6-Dihydroxyphenylacetate
C06866  
Capsaicin
C07086  
Phenylacetic acid
C07303  
4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
C08300  
D-Cathine
C08301  
D-Cathinone
C11457  
3-(3-Hydroxyphenyl)propanoic acid
C11588  
cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  
trans-3-Hydroxycinnamate
C12622  
cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  
trans-2,3-Dihydroxycinnamate
C12624  
2-Hydroxy-6-ketononatrienedioate
C14144  
5-Carboxy-2-pentenoyl-CoA
C14145  
(3S)-3-Hydroxyadipyl-CoA
C15524  
Phenylglyoxylyl-CoA
C16666  
Vanillylamine
C16719  
(-)-Norephedrine
C17268  
Pyruvophenone
C18202  
8-Methyl-6-nonenoic acid
C19945  
3-Oxo-5,6-dehydrosuberyl-CoA
C19946  
3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  
2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  
2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
Reference
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
Reference
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
KO pathway
 

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