KEGG   PATHWAY: hsa00450Help
Entry
hsa00450                    Pathway                                

Name
Selenocompound metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of other amino acids
BRITE hierarchy
Pathway map
Selenocompound metabolism
hsa00450

All organismsOrtholog table
Disease
H00183  
Homocystinuria
H00184  
Hypermethioninemia
H00761  
SEMD, Pakistani type
H01285  
Methylcobalamin deficiency type G (cblG)
Organism
Homo sapiens (human) [GN:hsa]
Gene
4548  
MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
1491  
CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
51540  
SCLY; selenocysteine lyase [KO:K01763] [EC:4.4.1.16]
56267  
CCBL2; cysteine conjugate-beta lyase 2 [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]
883  
CCBL1; cysteine conjugate-beta lyase, cytoplasmic [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]
7296  
TXNRD1; thioredoxin reductase 1 [KO:K00384] [EC:1.8.1.9]
10587  
TXNRD2; thioredoxin reductase 2 [KO:K00384] [EC:1.8.1.9]
114112  
TXNRD3; thioredoxin reductase 3 [KO:K00384] [EC:1.8.1.9]
11185  
INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.96 2.1.1.49]
9060  
PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.1.25 2.7.7.4]
9061  
PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.1.25 2.7.7.4]
22928  
SEPHS2; selenophosphate synthetase 2 [KO:K01008] [EC:2.7.9.3]
22929  
SEPHS1; selenophosphate synthetase 1 [KO:K01008] [EC:2.7.9.3]
118672  
PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  
SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
4141  
MARS; methionyl-tRNA synthetase [KO:K01874] [EC:6.1.1.10]
92935  
MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
Compound
C00017  
Protein
C00041  
L-Alanine
C01528  
Hydrogen selenide
C02535  
Dimethyl selenide
C05172  
Selenophosphoric acid
C05335  
L-Selenomethionine
C05336  
Selenomethionyl-tRNA(Met)
C05684  
Selenite
C05686  
Adenylylselenate
C05688  
L-Selenocysteine
C05689  
Se-Methyl-L-selenocysteine
C05690  
Se-Methylselenomethionine
C05695  
gamma-Glutamyl-Se-methylselenocysteine
C05697  
Selenate
C05698  
Selenohomocysteine
C05699  
L-Selenocystathionine
C05703  
Methaneselenol
C06481  
L-Seryl-tRNA(Sec)
C06482  
L-Selenocysteinyl-tRNA(Sec)
C16638  
O-Phosphoseryl-tRNA(Sec)
C18870  
Selenodiglutathione
C18871  
Glutathioselenol
C18872  
Trimethylselenonium
C18893  
1-Methylseleno-N-acetyl-D-galactosamine
C18902  
Methylselenic acid
C18904  
Methylselenopyruvate
C18905  
Methylselenocysteine Se-oxide
Reference
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem (2010)
Reference
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
Reference
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring  organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
Reference
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
Reference
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
KO pathway
 

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