KEGG   PATHWAY: hsa00512Help
Entry
hsa00512                    Pathway                                

Name
Mucin type O-glycan biosynthesis - Homo sapiens (human)
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
hsa00512  Mucin type O-glycan biosynthesis
hsa00512

Ortholog table
Module
hsa_M00056  O-glycan biosynthesis, mucin type core [PATH:hsa00512]
Disease
H00020  Colorectal cancer
H01188  Tn syndrome
H01193  Familial tumoral calcinosis (FTC)
Other DBs
BSID: 82977
GO: 0006493
Organism
Homo sapiens (human) [GN:hsa]
Gene
442117  GALNTL6; polypeptide N-acetylgalactosaminyltransferase like 6 [KO:K00710] [EC:2.4.1.41]
11227  GALNT5; polypeptide N-acetylgalactosaminyltransferase 5 [KO:K00710] [EC:2.4.1.41]
64409  GALNT17; polypeptide N-acetylgalactosaminyltransferase 17 [KO:K00710] [EC:2.4.1.41]
63917  GALNT11; polypeptide N-acetylgalactosaminyltransferase 11 [KO:K00710] [EC:2.4.1.41]
79695  GALNT12; polypeptide N-acetylgalactosaminyltransferase 12 [KO:K00710] [EC:2.4.1.41]
114805  GALNT13; polypeptide N-acetylgalactosaminyltransferase 13 [KO:K00710] [EC:2.4.1.41]
79623  GALNT14; polypeptide N-acetylgalactosaminyltransferase 14 [KO:K00710] [EC:2.4.1.41]
57452  GALNT16; polypeptide N-acetylgalactosaminyltransferase 16 [KO:K00710] [EC:2.4.1.41]
117248  GALNT15; polypeptide N-acetylgalactosaminyltransferase 15 [KO:K00710] [EC:2.4.1.41]
374378  GALNT18; polypeptide N-acetylgalactosaminyltransferase 18 [KO:K00710] [EC:2.4.1.41]
168391  GALNTL5; polypeptide N-acetylgalactosaminyltransferase like 5 [KO:K00710] [EC:2.4.1.41]
55568  GALNT10; polypeptide N-acetylgalactosaminyltransferase 10 [KO:K00710] [EC:2.4.1.41]
2590  GALNT2; polypeptide N-acetylgalactosaminyltransferase 2 [KO:K00710] [EC:2.4.1.41]
2591  GALNT3; polypeptide N-acetylgalactosaminyltransferase 3 [KO:K00710] [EC:2.4.1.41]
2589  GALNT1; polypeptide N-acetylgalactosaminyltransferase 1 [KO:K00710] [EC:2.4.1.41]
11226  GALNT6; polypeptide N-acetylgalactosaminyltransferase 6 [KO:K00710] [EC:2.4.1.41]
8693  GALNT4; polypeptide N-acetylgalactosaminyltransferase 4 [KO:K00710] [EC:2.4.1.41]
50614  GALNT9; polypeptide N-acetylgalactosaminyltransferase 9 [KO:K00710] [EC:2.4.1.41]
51809  GALNT7; polypeptide N-acetylgalactosaminyltransferase 7 [KO:K00710] [EC:2.4.1.41]
26290  GALNT8; polypeptide N-acetylgalactosaminyltransferase 8 [KO:K00710] [EC:2.4.1.41]
100528030  POC1B-GALNT4; POC1B-GALNT4 readthrough [KO:K00710] [EC:2.4.1.41]
56913  C1GALT1; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [KO:K00731] [EC:2.4.1.122]
29071  C1GALT1C1; C1GALT1 specific chaperone 1 [KO:K09653] [EC:2.4.1.-]
2650  GCNT1; glucosaminyl (N-acetyl) transferase 1, core 2 [KO:K00727] [EC:2.4.1.102]
9245  GCNT3; glucosaminyl (N-acetyl) transferase 3, mucin type [KO:K09662] [EC:2.4.1.-]
51301  GCNT4; glucosaminyl (N-acetyl) transferase 4, core 2 [KO:K09663] [EC:2.4.1.-]
6482  ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.99.4]
6483  ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.99.4]
55808  ST6GALNAC1; ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [KO:K03479] [EC:2.4.99.3]
192134  B3GNT6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 [KO:K00739] [EC:2.4.1.147]
9334  B4GALT5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.-]
Compound
C02189  [Protein]-L-serine
G00023  Tn antigen
G00024  T antigen
G00025   
G00026   
G00027   
G00028   
G00029   
G00030   
G00031   
G00032   
G00033   
G00034   
G00035  Sialyl-Tn antigen
G10611  UDP-N-acetyl-D-galactosamine
Reference
  Authors
Brockhausen I.
  Title
Pathways of O-glycan biosynthesis in cancer cells.
  Journal
Biochim Biophys Acta 1473:67-95 (1999)
DOI:10.1016/S0304-4165(99)00170-1
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
DOI:10.1074/jbc.M112457200
Reference
  Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
  Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
  Journal
Glycobiology 13:387-400 (2003)
DOI:10.1093/glycob/cwg044
Reference
  Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
  Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
  Journal
FEBS Lett 450:52-6 (1999)
DOI:10.1016/S0014-5793(99)00462-7
KO pathway
ko00512   

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