KEGG   PATHWAY: hsa00512Help
Entry
hsa00512                    Pathway                                

Name
Mucin type O-glycan biosynthesis - Homo sapiens (human)
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Mucin type O-glycan biosynthesis
hsa00512

All organismsOrtholog table
Module
O-glycan biosynthesis, mucin type core [PATH:hsa00512]
Disease
H00020  
Colorectal cancer
H01188  
Tn syndrome
H01193  
Familial tumoral calcinosis (FTC)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
442117  
GALNTL6; polypeptide N-acetylgalactosaminyltransferase-like 6 [KO:K00710] [EC:2.4.1.41]
11227  
GALNT5; polypeptide N-acetylgalactosaminyltransferase 5 [KO:K00710] [EC:2.4.1.41]
64409  
WBSCR17; Williams-Beuren syndrome chromosome region 17 [KO:K00710] [EC:2.4.1.41]
63917  
GALNT11; polypeptide N-acetylgalactosaminyltransferase 11 [KO:K00710] [EC:2.4.1.41]
79695  
GALNT12; polypeptide N-acetylgalactosaminyltransferase 12 [KO:K00710] [EC:2.4.1.41]
114805  
GALNT13; polypeptide N-acetylgalactosaminyltransferase 13 [KO:K00710] [EC:2.4.1.41]
79623  
GALNT14; polypeptide N-acetylgalactosaminyltransferase 14 [KO:K00710] [EC:2.4.1.41]
57452  
GALNT16; polypeptide N-acetylgalactosaminyltransferase 16 [KO:K00710] [EC:2.4.1.41]
117248  
GALNT15; polypeptide N-acetylgalactosaminyltransferase 15 [KO:K00710] [EC:2.4.1.41]
374378  
GALNT18; polypeptide N-acetylgalactosaminyltransferase 18 [KO:K00710] [EC:2.4.1.41]
168391  
GALNTL5; polypeptide N-acetylgalactosaminyltransferase-like 5 [KO:K00710] [EC:2.4.1.41]
55568  
GALNT10; polypeptide N-acetylgalactosaminyltransferase 10 [KO:K00710] [EC:2.4.1.41]
2590  
GALNT2; polypeptide N-acetylgalactosaminyltransferase 2 [KO:K00710] [EC:2.4.1.41]
2591  
GALNT3; polypeptide N-acetylgalactosaminyltransferase 3 [KO:K00710] [EC:2.4.1.41]
2589  
GALNT1; polypeptide N-acetylgalactosaminyltransferase 1 [KO:K00710] [EC:2.4.1.41]
11226  
GALNT6; polypeptide N-acetylgalactosaminyltransferase 6 [KO:K00710] [EC:2.4.1.41]
8693  
GALNT4; polypeptide N-acetylgalactosaminyltransferase 4 [KO:K00710] [EC:2.4.1.41]
50614  
GALNT9; polypeptide N-acetylgalactosaminyltransferase 9 [KO:K00710] [EC:2.4.1.41]
51809  
GALNT7; polypeptide N-acetylgalactosaminyltransferase 7 [KO:K00710] [EC:2.4.1.41]
26290  
GALNT8; polypeptide N-acetylgalactosaminyltransferase 8 [KO:K00710] [EC:2.4.1.41]
POC1B-GALNT4; POC1B-GALNT4 readthrough [KO:K00710] [EC:2.4.1.41]
56913  
C1GALT1; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [KO:K00731] [EC:2.4.1.122]
29071  
C1GALT1C1; C1GALT1 specific chaperone 1 [KO:K09653] [EC:2.4.1.-]
2650  
GCNT1; glucosaminyl (N-acetyl) transferase 1, core 2 [KO:K00727] [EC:2.4.1.102]
9245  
GCNT3; glucosaminyl (N-acetyl) transferase 3, mucin type [KO:K09662] [EC:2.4.1.-]
51301  
GCNT4; glucosaminyl (N-acetyl) transferase 4, core 2 [KO:K09663] [EC:2.4.1.-]
6482  
ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.99.4]
6483  
ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.99.4]
55808  
ST6GALNAC1; ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [KO:K03479] [EC:2.4.99.3]
192134  
B3GNT6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 [KO:K00739] [EC:2.4.1.147]
9334  
B4GALT5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.-]
Compound
C02189  
[Protein]-L-serine
G00023  
Tn antigen
G00024  
T antigen
G00025  
 
G00026  
 
G00027  
 
G00028  
 
G00029  
 
G00030  
 
G00031  
 
G00032  
 
G00033  
 
G00034  
 
G00035  
Sialyl-Tn antigen
G10611  
UDP-N-acetyl-D-galactosamine
Reference
  Authors
Brockhausen I.
  Title
Pathways of O-glycan biosynthesis in cancer cells.
  Journal
Biochim Biophys Acta 1473:67-95 (1999)
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
Reference
  Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
  Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
  Journal
Glycobiology 13:387-400 (2003)
Reference
  Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
  Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
  Journal
FEBS Lett 450:52-6 (1999)
KO pathway
 

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