KEGG   PATHWAY: hsa00561Help
Entry
hsa00561                    Pathway                                

Name
Glycerolipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Glycerolipid metabolism
hsa00561

All organismsOrtholog table
Module
Triacylglycerol biosynthesis [PATH:hsa00561]
Acylglycerol degradation [PATH:hsa00561]
Disease
H00154  
Hyperlipoproteinemia, type I
H00552  
Chromosome Xp21 deletion syndrome
H01117  
Chronic recurrent multifocal osteomyelitis (CRMO)
H01290  
Acute recurrent myoglobinuria
H01333  
Nonalcoholic fatty liver disease (NAFLD)
H02013  
Glycerol kinase deficiency
Drug
D00123  
Cyanamide (JP17)
D03747  
Ibrolipim (USAN/INN)
D10657  
Pradigastat sodium (USAN)
D10664  
Pradigastat (USAN)
Other DBs
Organism
Homo sapiens (human) [GN:hsa]
Gene
132158  
GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
231  
AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]
57016  
AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
10327  
AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
26007  
TKFC; triokinase and FMN cyclase [KO:K00863] [EC:4.6.1.15 2.7.1.29 2.7.1.28]
2712  
GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
2710  
GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
57678  
GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  
GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  
GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
84803  
GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
10554  
AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  
AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
55326  
AGPAT5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
253558  
LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.51 2.3.1.-]
154141  
MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
129642  
MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
56894  
AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
56895  
AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
8611  
PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  
PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  
PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
23175  
LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  
LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  
LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
84513  
PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
196051  
PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.1.3.4 3.1.3.81]
8525  
DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
8527  
DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
9162  
DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
1606  
DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
8526  
DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
1607  
DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
160851  
DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
1608  
DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
1609  
DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
139189  
DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
8694  
DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.76 2.3.1.75 2.3.1.20]
84649  
DGAT2; diacylglycerol O-acyltransferase 2 [KO:K11160] [EC:2.3.1.75 2.3.1.20]
346606  
MOGAT3; monoacylglycerol O-acyltransferase 3 [KO:K14456] [EC:2.3.1.22 2.3.1.20]
1056  
CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
57104  
PNPLA2; patatin like phospholipase domain containing 2 [KO:K16816] [EC:3.1.1.3]
80339  
PNPLA3; patatin like phospholipase domain containing 3 [KO:K13534] [EC:2.3.1.- 3.1.1.3]
5406  
PNLIP; pancreatic lipase [KO:K14073] [EC:3.1.1.3]
5407  
PNLIPRP1; pancreatic lipase related protein 1 [KO:K14074] [EC:3.1.1.3]
5408  
PNLIPRP2; pancreatic lipase related protein 2 (gene/pseudogene) [KO:K14075] [EC:3.1.1.3]
119548  
PNLIPRP3; pancreatic lipase related protein 3 [KO:K14076] [EC:3.1.1.3]
3990  
LIPC; lipase C, hepatic type [KO:K22283] [EC:3.1.1.3]
8513  
LIPF; lipase F, gastric type [KO:K14452] [EC:3.1.1.3]
9388  
LIPG; lipase G, endothelial type [KO:K22284] [EC:3.1.1.3]
4023  
LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
55750  
AGK; acylglycerol kinase [KO:K09881] [EC:2.7.1.94]
11343  
MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
116255  
MOGAT1; monoacylglycerol O-acyltransferase 1 [KO:K14458] [EC:2.3.1.22]
80168  
MOGAT2; monoacylglycerol O-acyltransferase 2 [KO:K14457] [EC:2.3.1.22]
2717  
GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
Compound
C00029  
UDP-glucose
C00040  
Acyl-CoA
C00093  
sn-Glycerol 3-phosphate
C00111  
Glycerone phosphate
C00116  
Glycerol
C00162  
Fatty acid
C00184  
Glycerone
C00197  
3-Phospho-D-glycerate
C00258  
D-Glycerate
C00416  
Phosphatidate
C00422  
Triacylglycerol
C00577  
D-Glyceraldehyde
C00631  
2-Phospho-D-glycerate
C00641  
1,2-Diacyl-sn-glycerol
C00681  
1-Acyl-sn-glycerol 3-phosphate
C00969  
3-Hydroxypropanal
C01885  
1-Acylglycerol
C02457  
Propane-1,3-diol
C03692  
1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
C04046  
3-D-Glucosyl-1,2-diacylglycerol
C04315  
2-Acyl-3-O-(beta-D-galactosyl)-sn-glycerol
C04872  
1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
C05401  
3-beta-D-Galactosyl-sn-glycerol
C06037  
Digalactosyl-diacylglycerol
C06038  
Acyl1-monogalactosyl-diacylglycerol
C06040  
Diglucosyldiacylglycerol
C06041  
Glycerophosphoglycoglycerolipid
C06042  
Lipoteichoic acid
C06364  
1,2-Diacyl-3-alpha-D-glucosyl-sn-glycerol
C06365  
alpha-Kojibiosyldiacylglycerol
C11521  
UDP-6-sulfoquinovose
C13508  
Sulfoquinovosyldiacylglycerol
C20897  
Glycerophosphoglycoglycerolipid
C20898  
Lipoteichoic acid
C20991  
1,2-Diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
Reference
PMID:8662716
  Authors
Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L.
  Title
Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
  Journal
J Biol Chem 271:13875-81 (1996)
DOI:10.1074/jbc.271.23.13875
Reference
PMID:8995384
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A.
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
DOI:10.1074/jbc.272.2.929
Reference
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A.
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
DOI:10.1074/jbc.M102576200
KO pathway
 

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