KEGG   PATHWAY: hsa00562Help
Entry
hsa00562                    Pathway                                

Name
Inositol phosphate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Inositol phosphate metabolism
hsa00562

All organismsOrtholog table
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:hsa00562]
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:hsa00562]
Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:hsa00562]
Disease
H00530  
Joubert syndrome
H00692  
Lowe syndrome
H00694  
Dent disease
H00700  
Centronuclear myopathy
H00865  
Lethal congenital contractural syndrome (LCCS)
H00957  
Fleck corneal dystrophy (FCD)
H01195  
VACTERL/VATER association
H01387  
Activated PI3K-delta syndrome (APDS)
Drug
D10189  
Pictilisib (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
5289  
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
4534  
MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.95 3.1.3.64]
8776  
MTMR1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8898  
MTMR2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8897  
MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
9110  
MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
55613  
MTMR8; myotubularin related protein 8 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9107  
MTMR6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9108  
MTMR7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
64419  
MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.95 3.1.3.64]
5297  
PI4KA; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
5298  
PI4KB; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
55361  
PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300  
PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
23396  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
138429  
PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like 1 [KO:K13712] [EC:2.7.1.68]
4952  
OCRL; oculocerebrorenal syndrome of Lowe [KO:K01099] [EC:3.1.3.36]
3633  
INPP5B; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
56623  
INPP5E; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
8867  
SYNJ1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
8871  
SYNJ2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
3635  
INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
3636  
INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
5288  
PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286  
PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  
PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
3631  
INPP4A; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
8821  
INPP4B; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
200576  
PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
79837  
PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
5305  
PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
8396  
PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
23236  
PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
5333  
PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
113026  
PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
84812  
PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
51196  
PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335  
PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
89869  
PLCZ1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
23007  
PLCH1; phospholipase C eta 1 [KO:K19006] [EC:3.1.4.11]
9651  
PLCH2; phospholipase C eta 2 [KO:K19006] [EC:3.1.4.11]
3613  
IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612  
IMPA1; inositol(myo)-1(or 4)-monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
54928  
IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7 3.1.3.25]
10423  
CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
51477  
ISYNA1; inositol-3-phosphate synthase 1 [KO:K01858] [EC:5.5.1.4]
3628  
INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
51763  
INPP5K; inositol polyphosphate-5-phosphatase K [KO:K01106] [EC:3.1.3.56]
27124  
INPP5J; inositol polyphosphate-5-phosphatase J [KO:K01106] [EC:3.1.3.56]
3632  
INPP5A; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
9562  
MINPP1; multiple inositol-polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.80 3.1.3.62]
3707  
ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706  
ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271  
ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
3705  
ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.134 2.7.1.159]
253430  
IPMK; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.151 2.7.1.140]
64768  
IPPK; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
55586  
MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
4329  
ALDH6A1; aldehyde dehydrogenase 6 family member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]
7167  
TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]
Compound
C00024  
Acetyl-CoA
C00092  
D-Glucose 6-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00137  
myo-Inositol
C00191  
D-Glucuronate
C00222  
3-Oxopropanoate
C00641  
1,2-Diacyl-sn-glycerol
C00691  
2,4,6/3,5-Pentahydroxycyclohexanone
C01177  
Inositol 1-phosphate
C01194  
1-Phosphatidyl-D-myo-inositol
C01204  
Phytic acid
C01220  
1D-myo-Inositol 1,4-bisphosphate
C01243  
1D-myo-Inositol 1,3,4-trisphosphate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01272  
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  
1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  
1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  
myo-Inositol 4-phosphate
C03659  
D-Bornesitol
C03660  
L-Bornesitol
C04006  
1D-myo-Inositol 3-phosphate
C04062  
D-myo-Inositol 1,3-bisphosphate
C04063  
D-myo-Inositol 3,4-bisphosphate
C04287  
3D-3,5/4-Trihydroxycyclohexane-1,2-dione
C04477  
1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520  
1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563  
D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579  
Inositol 1,2,3,5,6-pentakisphosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C06153  
scyllo-Inositol
C06892  
2-Deoxy-5-keto-D-gluconic acid
C06893  
2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  
1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  
1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  
1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737  
5-Deoxy-D-glucuronate
C19794  
CDP-1L-myo-inositol
C19799  
Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate
C19891  
1D-chiro-Inositol
C20251  
1-Keto-D-chiro-inositol
Reference
  Authors
Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y
  Title
The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.
  Journal
Microbiology 150:571-80 (2004)
Reference
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.
  Title
myo-Inositol catabolism in Bacillus subtilis.
  Journal
J Biol Chem 283:10415-24 (2008)
KO pathway
 

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