KEGG   PATHWAY: hsa00564Help
Entry
hsa00564                    Pathway                                

Name
Glycerophospholipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Glycerophospholipid metabolism
hsa00564

All organismsOrtholog table
Module
Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:hsa00564]
Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:hsa00564]
Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:hsa00564]
Disease
H00158  
Lecithin:cholesterol acyltransferase deficiency
H00207  
Rhizomelic chondrodysplasia punctata
H00654  
Barth syndrome (BTHS)
H00770  
Congenital myasthenic syndrome
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H01117  
Majeed syndrome
H01290  
Acute recurrent myoglobinuria
Drug
D00043  
Isoflurophate (USP)
D00196  
Physostigmine (USP)
D00469  
Pralidoxime chloride (USP)
D00487  
Pyridostigmine bromide (JP16/USP/INN)
D00667  
Demecarium bromide (USP/INN)
D00670  
Donepezil hydrochloride (JP16/USAN)
D00994  
Edrophonium chloride (JP16/USP/INN)
D00995  
Neostigmine bromide (JAN/USP/INN)
D00998  
Neostigmine methylsulfate (JP16/USP)
D01001  
Ambenonium chloride (JP16/INN)
D01228  
Distigmine bromide (JP16/INN)
D01572  
Pralidoxime iodide (JAN/USAN)
D02068  
Tacrine hydrochloride (USP)
D02173  
Galantamine hydrobromide (JAN/USAN)
D02193  
Ecothiopate iodide (JP16/INN)
D02418  
Physostigmine salicylate (JAN/USP)
D02558  
Rivastigmine tartrate
D02565  
Dimetacrine (INN)
D02729  
Itopride hydrochloride (JAN)
D03099  
Besipirdine hydrochloride (USAN)
D03239  
Ladostigil tartrate (USAN)
D03751  
Icopezil maleate (USAN)
D03822  
Rivastigmine (JAN/USAN/INN)
D03826  
Physostigmine sulfate (USP)
D04292  
Galantamine (USAN/INN)
D05215  
Obidoxime chloride (USAN)
D05590  
Pralidoxime mesylate (USAN)
D06288  
Velnacrine maleate (USAN)
D07869  
Donepezil (INN)
D08094  
Itopride (INN)
D08261  
Neostigmine (BAN)
D08555  
Tacrine (INN)
D08838  
Acotiamide hydrochloride hydrate (JAN)
D09750  
Ipidacrine hydrochloride hydrate (JAN)
Other DBs
Organism
Homo sapiens (human) [GN:hsa]
Gene
23171  
GPD1L; glycerol-3-phosphate dehydrogenase 1-like [KO:K00006] [EC:1.1.1.8]
2819  
GPD1; glycerol-3-phosphate dehydrogenase 1 (soluble) [KO:K00006] [EC:1.1.1.8]
2820  
GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [KO:K00111] [EC:1.1.5.3]
57678  
GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  
GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  
AGPAT6; 1-acylglycerol-3-phosphate O-acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
84803  
AGPAT9; 1-acylglycerol-3-phosphate O-acyltransferase 9 [KO:K13506] [EC:2.3.1.15]
10554  
AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  
AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
253558  
LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.51 2.3.1.-]
154141  
MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
129642  
MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
56894  
AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
56895  
AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
8443  
GNPAT; glyceronephosphate O-acyltransferase [KO:K00649] [EC:2.3.1.42]
56985  
ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent [KO:K01517] [EC:3.6.1.53 3.6.1.16 3.6.1.13]
8611  
PPAP2A; phosphatidic acid phosphatase type 2A [KO:K01080] [EC:3.1.3.4]
8613  
PPAP2B; phosphatidic acid phosphatase type 2B [KO:K01080] [EC:3.1.3.4]
8612  
PPAP2C; phosphatidic acid phosphatase type 2C [KO:K01080] [EC:3.1.3.4]
23175  
LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  
LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  
LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
8525  
DGKZ; diacylglycerol kinase, zeta [KO:K00901] [EC:2.7.1.107]
8527  
DGKD; diacylglycerol kinase, delta 130kDa [KO:K00901] [EC:2.7.1.107]
9162  
DGKI; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
1606  
DGKA; diacylglycerol kinase, alpha 80kDa [KO:K00901] [EC:2.7.1.107]
8526  
DGKE; diacylglycerol kinase, epsilon 64kDa [KO:K00901] [EC:2.7.1.107]
1607  
DGKB; diacylglycerol kinase, beta 90kDa [KO:K00901] [EC:2.7.1.107]
160851  
DGKH; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
1608  
DGKG; diacylglycerol kinase, gamma 90kDa [KO:K00901] [EC:2.7.1.107]
1609  
DGKQ; diacylglycerol kinase, theta 110kDa [KO:K00901] [EC:2.7.1.107]
56994  
CHPT1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
10390  
CEPT1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.2 2.7.8.1]
5337  
PLD1; phospholipase D1, phosphatidylcholine-specific [KO:K01115] [EC:3.1.4.4]
5338  
PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
23646  
PLD3; phospholipase D family, member 3 [KO:K16860] [EC:3.1.4.4]
122618  
PLD4; phospholipase D family, member 4 [KO:K16860] [EC:3.1.4.4]
3931  
LCAT; lecithin-cholesterol acyltransferase [KO:K00650] [EC:2.3.1.43]
8399  
PLA2G10; phospholipase A2, group X [KO:K01047] [EC:3.1.1.4]
26279  
PLA2G2D; phospholipase A2, group IID [KO:K01047] [EC:3.1.1.4]
30814  
PLA2G2E; phospholipase A2, group IIE [KO:K01047] [EC:3.1.1.4]
50487  
PLA2G3; phospholipase A2, group III [KO:K01047] [EC:3.1.1.4]
64600  
PLA2G2F; phospholipase A2, group IIF [KO:K01047] [EC:3.1.1.4]
81579  
PLA2G12A; phospholipase A2, group XIIA [KO:K01047] [EC:3.1.1.4]
84647  
PLA2G12B; phospholipase A2, group XIIB [KO:K01047] [EC:3.1.1.4]
5319  
PLA2G1B; phospholipase A2, group IB (pancreas) [KO:K01047] [EC:3.1.1.4]
5322  
PLA2G5; phospholipase A2, group V [KO:K01047] [EC:3.1.1.4]
5320  
PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid) [KO:K01047] [EC:3.1.1.4]
391013  
PLA2G2C; phospholipase A2, group IIC [KO:K01047] [EC:3.1.1.4]
123745  
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
8398  
PLA2G6; phospholipase A2, group VI (cytosolic, calcium-independent) [KO:K16343] [EC:3.1.1.4]
151056  
PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
11145  
PLA2G16; phospholipase A2, group XVI [KO:K16817] [EC:3.1.1.4 3.1.1.32]
54947  
LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
79888  
LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
254531  
LPCAT4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.- 2.3.1.23]
10162  
LPCAT3; lysophosphatidylcholine acyltransferase 3 [KO:K13515] [EC:2.3.1.- 2.3.1.23]
10434  
LYPLA1; lysophospholipase I [KO:K06128] [EC:3.1.1.5]
23659  
PLA2G15; phospholipase A2, group XV [KO:K06129] [EC:3.1.1.5]
11313  
LYPLA2; lysophospholipase II [KO:K06130] [EC:3.1.1.5]
10908  
PNPLA6; patatin-like phospholipase domain containing 6 [KO:K14676] [EC:3.1.1.5]
375775  
PNPLA7; patatin-like phospholipase domain containing 7 [KO:K14676] [EC:3.1.1.5]
1103  
CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
43  
ACHE; acetylcholinesterase (Yt blood group) [KO:K01049] [EC:3.1.1.7]
1119  
CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.82 2.7.1.32]
1120  
CHKB; choline kinase beta [KO:K14156] [EC:2.7.1.82 2.7.1.32]
162466  
PHOSPHO1; phosphatase, orphan 1 [KO:K06124] [EC:3.1.3.75]
9468  
PCYT1B; phosphate cytidylyltransferase 1, choline, beta [KO:K00968] [EC:2.7.7.15]
5130  
PCYT1A; phosphate cytidylyltransferase 1, choline, alpha [KO:K00968] [EC:2.7.7.15]
85465  
EPT1; ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) [KO:K00993] [EC:2.7.8.1]
55500  
ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
55224  
ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
5833  
PCYT2; phosphate cytidylyltransferase 2, ethanolamine [KO:K00967] [EC:2.7.7.14]
64850  
ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
10400  
PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17]
1040  
CDS1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [KO:K00981] [EC:2.7.7.41]
8760  
CDS2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [KO:K00981] [EC:2.7.7.41]
9791  
PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
81490  
PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
23761  
PISD; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
9489  
PGS1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
54675  
CRLS1; cardiolipin synthase 1 [KO:K08744] [EC:2.7.8.-]
6901  
TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
9926  
LPGAT1; lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
10423  
CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
79143  
MBOAT7; membrane bound O-acyltransferase domain containing 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  
Acyl-CoA
C00084  
Acetaldehyde
C00093  
sn-Glycerol 3-phosphate
C00111  
Glycerone phosphate
C00114  
Choline
C00157  
Phosphatidylcholine
C00189  
Ethanolamine
C00269  
CDP-diacylglycerol
C00307  
CDP-choline
C00344  
Phosphatidylglycerol
C00346  
Ethanolamine phosphate
C00350  
Phosphatidylethanolamine
C00416  
Phosphatidate
C00513  
CDP-glycerol
C00570  
CDP-ethanolamine
C00588  
Choline phosphate
C00623  
sn-Glycerol 1-phosphate
C00641  
1,2-Diacyl-sn-glycerol
C00670  
sn-Glycero-3-phosphocholine
C00681  
1-Acyl-sn-glycerol 3-phosphate
C01194  
1-Phosphatidyl-D-myo-inositol
C01210  
N-Methylethanolamine phosphate
C01233  
sn-Glycero-3-phosphoethanolamine
C01241  
Phosphatidyl-N-methylethanolamine
C01996  
Acetylcholine
C02737  
Phosphatidylserine
C03372  
Acylglycerone phosphate
C03819  
1-Acylglycerophosphoinositol
C03872  
L-Serine-phosphoethanolamine
C03892  
Phosphatidylglycerophosphate
C03974  
2-Acyl-sn-glycerol 3-phosphate
C04230  
1-Acyl-sn-glycero-3-phosphocholine
C04233  
2-Acyl-sn-glycero-3-phosphocholine
C04308  
Phosphatidyl-N-dimethylethanolamine
C04438  
1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  
3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  
2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
C05973  
2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  
2-Acyl-sn-glycero-3-phosphoserine
C05976  
Aminoacyl-phosphatidylglycerol
C05980  
Cardiolipin
C06771  
Triethanolamine
C06772  
Diethanolamine
C13482  
Phosphodimethylethanolamine
C18059  
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
C18125  
1-Acyl-sn-glycero-3-phosphoserine
C18126  
1-Acyl-sn-glycero-3-phosphoglycerol
C18129  
Monolysocardiolipin
C18168  
Diacylglycerylhomoserine
C18169  
Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  
2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  
2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
KO pathway
 

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